School of Bio-Medical Sciences (Bio-Medical) Collections
Recent Submissions
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M. Tuberculosis 85b messenger ribonucleic acid as a biomarker for treatment response among multidrug resistant tuberculosis patients attending Mulago hospital, Uganda
(Makerere University, 2021-04-28)Background: The occurrence of multidrug resistance (MDR) is one of the major bottlenecks to TB elimination. This is worsened by the lack of reliable point of care (POC) tests for monitoring MDR TB patients with viable M. ... -
Effect of mixed mycobacterium tuberculosis infection on the performance of rapid molecular diagnostic test among patients initiating MDR-TB treatment at Mulago National TB treatment
(Makerere University, 2021-04-26)Introduction: Performance of rapid molecular diagnostic test in detecting drug resistant Mycobacterium tuberculosis (MTB) is key in controlling the infection and treatment response of TB. Presence of mixed MTB infection ... -
Stakeholders perceptions and experiences regarding research at Makerere University College of Health Sciences
(Makerere University, 2021-02-17)The study purposed to explore the perceptions and experiences of key research stakeholders at Makerere College of Health Sciences (MaKCHS) and affiliate research institutions. Several research studies conducted at the ... -
Evaluation of quality of hepatitis B vaccines circulating on the Ugandan market
(Makerere University, 2021-04-28)Vaccination is the greatest public health intervention in these modern times. Since the Ministry of Health -Uganda rolled out the Hepatitis B vaccination program, there has been a continuous decrease in the number of new ... -
Detection of Leishmania in human blood and tissue exudate ingested by Tunga penetrans
(International Scholars Journals, 2020-09)Communities in Uganda are experiencing a multiparasitism, blood microscopy often reveals Leishmania and microfilaria in patients with anaemia, haemorrhage and splenomegaly. Many are likely asymptomatic and probably exposed ... -
Evaluation of hepatitis b surface antigen (hbsag) as a surrogate marker for hepatitis b viral load estimation.
(Makerere University, 2021-04-28)Background: A Hepatitis B Virus (HBV) viral load measurement is recommended for diagnosis and monitoring of patients on treatment for Chronic Hepatitis B (CHB). However, these diagnostic techniques are molecular-based ... -
T- cell activation and senescence phenotypes among people living with hiv-1 with advanced immunosuppression
(Makerere University, 2021-04-29)INTRODUCTION. T cell activation and senescence phenotype markers among HIV-1 infected patients with advanced immunosuppression are key components in the immunopathogenesis of HIV. In HIV infection, senescence is accelerated ... -
Diagnostic accuracy of various hepatitis c rapid tests against elisa in detection of hepatitis c infection.
(Makerere University, 2021-03-25)INTRODUCTION: HCV is one of the leading causes of liver disease in the world with over 71 million people infected and in Uganda, HCV sero-prevalence estimates range from 0.0% to 14.6%. It is predominantly a blood borne ... -
Vancomycin Resistance among Methicillin Resistant Staphylococcus aureus Isolates in Uganda.
(Makerere University, 2021-04-01)Introduction Methicillin resistant Staphylococcus aureus is defined as Staphylococcus aureus strain resistant to almost all Beta-lactams antimicrobial agents. The increased burden of methicillin resistant Staphylococcus ... -
Compensating health research participants : Research Ethics Committee members’ perspectives and ethical guidance
(Makerere University, 2020-06-25)Background: Research participants in resource-poor settings face a risk of exploitation due to widespread poverty and their limited experience and understanding of research. Researchers have an obligation to protect research ... -
Exploring the disclosure of risks and benefits of depo-provera by health care workers at public health facilities in Kyotera and Rakai districts
(Makerere University, 2021-02-22)Background: Contraception is a basic human right for all women as articulated in the Universal Declaration of Human Rights. Every girl and woman should have the right to choose what contraception method, when they want, ... -
Role of Killer-cell Immunoglobulin-like Receptors and Human Leukocyte Antigens in Transmission and Severity of Malaria in Uganda
(Makerere University, 2021-04-08)Background Malaria is a life-threatening disease caused by Plasmodium falciparum. In 2018, there were an estimated 228 million cases of malaria worldwide and 405,000 malaria deaths. Malaria burden is greatly affected by ... -
Motivation to participate in HIV/AIDS clinical trials among trial participants at joint clinical research centre, Lubowa, Wakiso district, Uganda
(Makerere University, 2021-03-10)Background: Participation from diverse population groups in clinical trials is important but also, allowing voluntary decision making is equally important. To understand the dynamics of decision-making, contextual focus ... -
Sputum microRNA profiles of treatment-naïve and patients on antituberculosis therapy in Mulago National Referral Hospital
(Makerere University, 2021-03-29)Background: Worldwide, tuberculosis (TB) is the leading cause of death due to a single infectious agent. This is attributed to the limitations of the current diagnostic tests in terms of sensitivity and specificity. ... -
Longitudinal changes in cd4+ and cd8+t cell phenotype and activation marker expression among cryptococcal meningitis patients initiating on anti retroviral therapy
(Makerere University, 2017-12-04)Introduction: Since the introduction of antiretroviral therapy (ART), the prognosis for HIV-1 patients has improved immensely with CD4+T cell recovery and viral suppression. Early initiation of ART has been associated with ... -
Interferon Sensitivity Profiles of HIV-1 Transmitter Founder Viruses of Subtypes A, D and AD Recombinants in Uganda.
(Makerere University, 2021-02-08)ABSTRACT Background: In 80–90% of HIV-1 discordant partners, infection of the naive partner always results from the successful transmission and propagation of a single virus variant, termed the Transmitter Founder (TF) ... -
Antibody responses to Mycobacterial glycans and glycolipids as potential correlates of protection from mycobacterium tuberculosis infection in BCG vaccinated children
(Makerere University, 2021-04-01)Background: Globally, tuberculosis (TB) has remained the main cause of death from a single infectious pathogen. The only licensed TB vaccine to date, BCG, has variable efficacy. We need to understand the mechanism ... -
Barriers to partner HIV serostatus disclosure among postnatal mothers on option b+ in Rukungiri district
(Makerere University, 2019-12-02)Introduction; Self-disclosure of one’s positive HIV serostatus to partners is an important step in the pathway of transmission prevention through sexual risk reduction and uptake of treatment and support services. Disclosure ... -
Pulmonary dimorphic fungal infections in HIV infected patients with NON-TB chronic cough at Mulago Hospital, Uganda
(Makerere University, 2021-03)Introduction: Dimorphic fungi cause infection following inhalation of spores (conidia) into the pulmonary system. In the lower respiratory tract the conidia transform into the yeast phase which are engulfed by alveolar ... -
Prognostic factors for overall survival of patients with prostate cancer in Kyadondo county, Uganda
(Makerere University, 2021-02-24)Background: Prostate cancer (PCa) remains the most common cancer among men in sub-Saharan Africa (SSA). Uganda has the highest incidence and mortality of PCa in the East Africa region. The overall survival of patients with ...
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