School of Bio-Medical Sciences (Bio-Medical) Collections
Recent Submissions
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Deciphering Rifampicin resistance among Tuberculosis patients who have trace and indeterminate results on Xpert MTB/RIF ultra assay
(Makerere University, 2024-10-22)Although WHO endorsed the GeneXpert test as the first initial test for Tuberculosis diagnosis, some of the GeneXpert Ultra results include MTB detected trace, RIF resistance indeterminate which necessitates a sample rerun, ... -
Evidence of molecular adaptive evolution of SARS-CoV-2 in Uganda using whole genome sequences
(Makerere University, 2024-10)Background: Seasonal influenza and coronaviruses both exhibit continual adaptive evolution during endemic circulation in the human population. The rapid evolution of human pathogenic RNA viruses can undermine the efforts ... -
Selected bacterial etiology of acute diarrhea in under five children at Mulago National Referral Hospital Kampala, Uganda.
(Makerere University, 2024-10)Background: Diarrhea is understood as the passing of three or more passages of loose or watery stools per day according to WHO and is considered among the major causes of childhood mortality and morbidity. Diarrhea kills ... -
Prevalence, associated risk factors, and consequences of medication errors in poultry practice in Wakiso district
(Makerere University, 2024)Medication errors are a serious health challenge in both humans and animals including in poultry practice in Uganda. However, limited information exists on the extent of burden of medication errors, risk factors and its ... -
Understanding genetic diversity and rapid drug resistance prediction in mycobacterium tuberculosis from whole-genome sequence and other epidemiological data
(Makerere University, 2024-06)Tuberculosis (TB) remains one of the major global health problems with an estimated 1.6 million deaths worldwide. The availability of whole-genome sequence (WGS) data offers a good avenue for understanding genetic diversity ... -
Antinociceptive activity and acute toxicity profile of Leucus calostachys olive in animal models
(Makerere university, 2024-11)Pain remains a cardinal sign and symptom for most diseases and a major reason for patients visiting healthcare providers. Conventional treatment modalities do not adequately address pain, and as a result, most local ... -
Evaluation of hypoglycemic activity, phytochemical composition and acute toxicity of Opuntia humifusa Raf. cladode extracts in Wistar albino rats
(Makerere University, 2024-10-29)Background Local communities in Central Uganda are using the cladodes of Opuntia humifusa in the treatment of diabetes mellitus with the claim that the plant is effective. However, efficacy and safety of the plant is not ... -
Performance evaluation of truenat test for detection of pulmonary tuberculosis among HIV symptomatic patients at Lira Regional Referral Hospital
(Makerere University, 2024)Background: About a quarter of the world’s population has been infected with Mycobacterium tuberculosis, in immune compromised people like in HIV- infected persons, the risk of developing tuberculosis is 22 times higher. ... -
Effect of substitution mutations on the temporal dynamics of HIV-1 subtype A1 and D in the Ugandan epidemic
(Makerere University, 2024)Background: Subtypes A1, D and inter-subtype recombinants dominate the Uganda HIV-1 epidemic. This diversity has affected disease diagnosis and therapeutics. Predictive modeling could guide better understanding of the ... -
Identification of unique molecular signatures in the envelope Glycoproteins of HIV-1 transmitted/founder viruses from East Africa
(Makerere University, 2024)Background: HIV-1 mucosal transmission undergoes a genetic bottleneck that allows a single virus termed HIV-1 Transmitted/Founder (T/F) virus to establish a productive clinical infection in most heterosexual transmission ... -
Characterization of ESBL producing gram negative uropathogenic bacteria isolated from patients with urinary yract infections from Mbeya, Tanzania
(Makerere University, 2024)Background: The emergence and spread of drug-resistant pathogens, such as ESBL-producing Gram-negative bacteria continue to threaten our ability to treat common infections causing a huge burden to our healthcare systems. ... -
Development of an antigen capture ELISA for detection of SARS-CoV-2
(Makerere University, 2024)Background. In December 2019, the World Health Organization (WHO) declared COVID-19 a global pandemic causing over 700 million cases and more than 7 million deaths globally. In Uganda, over 40,408 cases with 334 deaths ... -
Methicillin resistant staphylococcus on inanimate objects in paediatric treatment units of Mulago National Referral Hospital
(Makerere University, 2024)Background: Hospital environment and inanimate surfaces have been reported to be colonised by different pathogens. Contact with colonised objects may lead to pathogen transmission resulting in increased morbidity and ... -
Replication, fine-mapping and causal inference of genetic loci associated with major depressive disorder among participants of the Uganda genome resource.
(Makerere University, 2024-10-17)Background: Major depressive disorder (MDD) is the leading cause of disability worldwide, with significant consequences like poor health outcomes, premature death, and reduced productivity. Twin-based studies have shown ... -
T cell immune memory and protective correlates in Ugandans with mild Covid-19 disease.
(Makerere University, 2024-10-22)Background: This study explores T cell immune memory and protective correlates in Ugandans with mild COVID-19 disease, focusing on those with low immunoglobulin G (IgG) antibody levels. Understanding the mechanisms that ... -
Predicting suicidality in people living with HIV in Uganda: A machine learning approach
(Makerere University, 2024-10)Background Suicidality is a major risk factor for future suicide attempts and completed suicide. People living with HIV (PLWH) are at a higher risk of fatal suicide attempts compared to the general population due to the ... -
Extended spectrum beta lactamase gram negative bacteria contamination of inanimate objects in Paediatric wards at Mulago National Referral Hospital in Uganda
(2024)Background: Antimicrobial resistance (AMR) is a global crisis that endangers the efficacy of antibiotics and also the treatment provided. Extended Spectrum Beta Lactamase (ESBL) resistance among beta lactams especially ... -
Antimicrobial resistance among helicobacter bacteria isolates from patients attending the gastroenterology unit at Nsambya hospital Kampala, Uganda
(Makerere University, 2024-09)Background: It is confirmed that 95% of duodenal and 80% of gastric ulcers are due to Helicobacter infections. Helicobacter diagnosis is mainly by urea breath test, blood antibody test, stool antigen test, gastric biopsy ... -
Diagnostic accuracy of anti-mycobacterial protein 51 antibodies as a biomarker for latent TB infection in asymptomatic HIV positive individuals
(Makerere University, 2024)Background: Tuberculosis (TB) continues to be a major global public health concern more so in sub-Saharan Africa and Uganda in particular due to inaccessibility to accurate, rapid and reliable diagnostic methods on top of ... -
Development and evaluation of various SARS-CoV-2 detection tests in Nasopharyngeal specimens in Uganda
(Makerere University, 2024)Background: Although the WHO recommends RT-PCR as reference standard method for detection of SARS-CoV-2 nucleic acid when diagnosing COVID-19 and tracing of contacts, this test is costly, primarily designated for specialised ...
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