School of Bio-Medical Sciences (Bio-Medical) Collections
Recent Submissions
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Reverse vaccinology and molecular docking as tools to identify potential vaccine candidates against drug-resistant Mycobacterium tuberculosis and Mycobacterium bovis
(Makerere University, 2022-03-29)The emergence of multi-drug-resistant Mycobacterium tuberculosis (M.tb) and Mycobacterium bovis (M.bovis), the causative agents of Tuberculosis (TB) and zoonotic TB respectively are of significant threat to public health. ... -
Characterizing the composition of the airway microbiota of patients with COPD in a rural setting in Uganda using shotgun metagenomics, a case control study
(Makerere university, 2022-10-25)Introduction: Diverse airway microbiota play an important role in the development and integrity of the immune system that limits growth of pathogenic microorganisms and clearing bacterial infections. Community shifts from ... -
Breast Cancer Molecular Subtype Prevalence and Commonly Mutated Genes in Triple Negative Breast Cancer in Uganda
(Makerere University, 2022-11-25)Breast cancer is the second commonest cancer in women in Uganda, accounting for about 21% of all cancer related mortality in women in Uganda. An estimated 35-36% of all breast cancer patients in Uganda have triple negative ... -
Autopsy survey of histopathological features and immunohistochemical markers of dementia in medico-legal deaths at Mulago hospital and KCCA mortuaries, Uganda
(Makerere University, 2022-11-22)Background: Dementia is a neurodegenerative disorder characterized by an irreversible cognitive decline. Although previously associated with old age, in people aged 65 and above, recent studies have reported early-onset ... -
Unravelling the genetic risk associated with major depressive disorder among an ethnically diverse African ancestry population
(Makerere University, 2022-03)Major depressive disorder (MDD), which is a significant contributor to the global health burden is characterised by a pervasive low mood and an inability to feel pleasure in normally pleasurable activities. Most MDD genetic ... -
Monitoring antibacterial use in children under five years in rural communities of Northern Uganda
(Makerere University, 2022)Background: Acute respiratory tract infections (ARIs) and diarrhea are leading causes of childhood morbidity and mortality in low- and middle-income countries (LMICs), the burden is high among children under five years of ... -
Characterisation of Resistance Associated Variants (RAVs) to the newly approved anti-tuberculosis drugs Delamanid, Pretomanid, Bedaquiline, Clofazimine and Linezolid in isolates from a 2016/2017 Tanzanian Anti-Tuberculosis Drug Resistance Survey
(Makerere University, 2022)Background: Drug-resistant Tuberculosis (TB) undermines the effort to curb TB disease. It is associated with higher treatment costs, longer treatment periods and more adverse effects (Jeon, 2015). Recently, three new ... -
Stool-based xpert ultra testing for pulmonary tuberculosis in children in Kampala, Uganda
(Makerere University, 2021-02-25)Background.. Globally, the diagnosis of tuberculosis (TB) in children is challenging principally because of the paucibacillary nature of TB in children and the difficulty in obtaining good quality sputum samples. More ... -
Determination of Interleukin 35 Levels as Inhibitory Cytokine in type 2 diabetic patients infected with latent tuberculosis at Mulago hospital, Uganda
(Makerere University, 2021-04-12)Background: Mycobacterium tuberculosis (Mtb) remains a successful pathogen causing tuberculosis (TB), and the burden of TB disease is constantly increasing. Although great progress has been made in delineating the disease, ... -
Aspergillus sensitisation and asthma in Uganda
(Makerere University, 2022-10-31)Background: Asthma is one of the neglected diseases in Africa and occurs at a high prevalence. Allergic fungal diseases have been reported to complicate asthma progression and treatment outcomes. Aspergillus fumigatus ... -
Prevalence of Antimalarial self- medication and artemisinin genotypic resistance in plasmodium falciparum parasites isolated from malaria symptomatic patients attending Dokolo Health Centre
(Makerere University, 2022-09-14)Background: Malaria remains the major cause of death in sub-Saharan Africa. Interventions like use of insecticide treated mosquito nets (ITNs), IRS, antimalarial drugs have been used to combat malaria in Uganda with minimal ... -
Colistin resistance among gram negative rods carried in the intestinal tract of patients admitted in the ICU of Mulago National Referral Hospital
(Makerere University, 2022-04)Background: The limited options for treatment of infections caused by MDR or XDR bacteria prompted the reintroduction of colistin, which coupled with extensive use in food-producing animals is driving increasing resistance ... -
Comparative genomics of Staphylococcus aureus isolates from Africa using virulence and drug resistance markers
(Makerere University, 2022-08)Introduction There is wide diversity among Staphylococcus aureus lineages colonizing and infecting the African population, yet information on S. aureus infections in Africa is limited. Africa bears a particularly high ... -
Developing an automated panel design tool for SNP-Based Targeted Amplicon sequencing of Schistosoma mansoni populations
(Makerere University, 2022-08-26)Genomic surveillance of Schistosomiasis across endemic regions could provide insights into the efficacy of current control strategies and allow the impact of selection on the parasite genome to be monitored, providing early ... -
Microbiome metatranscriptomics of the black soldier fly larvae gut for identification and functional characterization of lignocellulosic biomass-degrading microbes
(Makerere University, 2021-12)Second-generation biofuel production has emerged as a sustainable and alternative energy option to the fast depleting, ecologically unfriendly petroleum-based fuels. Second-generation biofuels are produced from lignocellulosic ... -
Developing an Automated Panel Design Tool for SNP-Based Targeted Amplicon Sequencing of Schistosoma mansoni Populations
(Makerere University, 2022-08-26)Genomic surveillance of Schistosomiasis across endemic regions could provide insights into the efficacy of current control strategies and allow the impact of selection on the parasite genome to be monitored, providing early ... -
Non-BRCA breast cancer predisposing variants identified in Kenyan patients using whole-exome sequencing
(Makerere University, 2022-07)Background: Breast cancer is a leading cause of cancer-related mortality in women worldwide. This disease is reported to be associated with mutations in several predisposing genes in addition to the long known BRCA1/2. ... -
Simulation of clonal expansion and latent HIV reservoir size prediction using machine learning in virally suppressed individuals in Uganda
(Makerere University, 2022-07)Background: HIV can survive as pro-viruses that do not undergo transcription mostly within resting memory CD4+ T cells despite prolonged antiretroviral therapy (ART). This Latent Viral Reservoir (LVR) has an extremely long ... -
In vitro activity of mycobacteriophages against Mycobacterium tuberculosis biofilms
(Makerere University, 2021-03)Tolerance of Mycobacterium tuberculosis to antibiotics has been associated with its tendency to grow in cell aggregates known as biofilms. These biofilms consist of layers of cells covered by a lipid-rich extracellular ... -
Comparative genomics and antibiotic – resistance determinants of clinical pseudomonas aeruginosa isolates from Kenya
(Makerere University, 2022)Pseudomonas aeruginosa is a leading cause of nosocomial infections worldwide. It causes a range of debilitating infections, have a propensity for developing antimicrobial resistance, and present with a variety of dangerous ...
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