School of Bio-Medical Sciences (Bio-Medical)
Recent Submissions
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In vitro efficacy of bacteriophages against Extended-spectrum β-Lactamase producing Escherichia coli Isolated from Patients with Urinary Tract Infections
(Makerere University, 2021-04)Background: Escherichia coli, a gram-negative bacterial pathogen, which harbors extended spectrum β-lactamase enzymes (ESBLs) is the major cause of UTIs. The wide spread emergence and expansion of ESBL producing E. coli ... -
Evaluation of antidepressant effects and safety of Lavendula angustifolia aqueous and total crude leaf extracts in Wistar albino rats.
(Makerere University, 2023-07-28)Introduction: Depression continues to be a major problem in Ugandan population and communities’ use medicinal plants like L. angustifolia (Lavandula angustifolia) for its treatment.Objective: To establish the antidepressant ... -
Evaluation of the Diagnostic Validity of the HIV VISITECT CD4 Point-of-Care Rapid Diagnostic Test Using PIMA Analyzer as the Gold Standard in Uganda.
(Makerere University, 2023-09-30)Background: HIV remains prevalent in Uganda, and the cluster of differentiation-4 (CD4) markers are widely used to support and monitor disease progression. Objectives: This study aimed to compare the diagnostic validity ... -
Mutations in MDR-TB Isolates from Bedaquiline-Resistance Conferring Mulago Hospital Kampala, Uganda
(Makerere University, 2023-11-20)Introduction: In 2018, based on an evidence-based policy, the World Health Organization (WHO) updated its guidelines on the treatment of drug-resistant tuberculosis with recommendation of bedaquiline as a core drug in the ... -
L everaging on the Cross-Reactivity and recovery of leptospira serovars in stored cultures to mitigate limitations of the Microscopic Agglutination Test
(Makerere University, 2023-11-13)Leptospirosis is one of the most widely spread bacterial zoonotic that is endemic in subtropical and tropical countries; accounting for a global annual incidence of 1.03 million human cases and 58,900 deaths. (Alinaitwe ... -
Genomic determinants of virulence and antimicrobial resistance in colistin resistant Klebsiella pneumoniae isolates from Mulago National Referral Hospital
(Makerere University, 2023-08-29)Introduction: Multidrug resistance and high virulence in K. pneumoniae are of particular concern and have emerged as critically alarming threats to the global community. Worringly, K.pneumoniae has become resistant to ... -
Evaluation of the ameliorative effects of the methanolic and total crude extracts of Persea americana seeds on biochemical and haematological parameters in wistar albino rats induced with type 2 diabetes mellitus.
(Makerere University, 2023-11)Diabetes Mellitus is a chronic hyperglycaemic condition caused by low insulin production with 2 major types i.e., Type 1 and Type 2 DM (NIDDM). Type 2 DM accounts for 90% of DM cases and its global prevalence is expected ... -
Identification of loci associated with environmental adaptation in indigenous cattle of Uganda
(Makerere University, 2023-11)Cattle are invaluable to the people of Uganda. They are a source of pride of tribes and are also used in social functions. In Uganda, local breeds of cattle are kept due to their tolerance to locally prevailing animal pests ... -
Occurrence of extended Spectrum Beta-Lactamase producing Enterobacteriaceae in wastewater and receiving water bodies.
(Makerere University, 2023)Antimicrobial resistance is taking center-stage in increasing morbidity and mortality, especially in Low- and middle-income countries like Uganda. WHO drew a roadmap to increase antimicrobial resistance surveillance using ... -
The HBV Serological patterns, Treatment eligibility, Genotypes and the TNF-α-863C/A & 1031 T/C Promoter gene polymorphisms in a high and low endemic region of Uganda.
(Makerere University, 2023-04-14)ABSTRACT Introduction: There is a disparity in HBV endemicity in Uganda. This can be influenced by the HBsAg seronegative persons who continue to shade the virus, chronically infected HBV not initiated on therapy, the ... -
Effects of Helminth Infections on Type-2 Immune Responses in children with asthma
(Makerere University, 2023-11-14)Background: Both asthma and helminths demonstrate a predominant type-2 immune response. Additionally, helminths have been demonstrated to have immuno-modulatory roles in allergic conditions such as asthma. Therefore, the ... -
African human variants that potentially impact the outcome of SARS-CoV-2 infection
(Makerere University, 2023-11-15)Introduction: The SARS-CoV-2 pandemic has had an unprecedented global impact, resulting in millions of confirmed cases and deaths. However, the severity and death rates varied among different ethnicities and geographical ... -
Ddiagnostic accuracy of mycobacterium.tuberculosis dna as detected by the top assay among individuals with paucibillary TB
(Makerere University, 2023-11)Background: One of the major reasons leading to the increased incidence of TB is the lack of a diagnostic with high sensitivity that can be relied on to capture even patients with low burden TB. This had been attempted by ... -
Immunological Biomarkers among patients with Severe COVID-19
(Makerere University, 2023-11)Background: SARS-COV 2 is characterized by a heterogenous disease course in which some cases may be asymptomatic, mild, and severe which is life-threatening. Most hospitalized patients with COVID-19 have been found to have ... -
Bacterial profile and antimicrobial susceptibility patterns of isolates from surgical site infections at Luwero hospital
(Makerere University, 2023-11-14)Background: A surgical site infection (SSI) is an infection that develops within at most 30 days following a surgical procedure or after one year in case if an implant was placed. The American Centers for Disease Control ... -
Bacterial-Derived Outer Membrane Vesicles in Chronic Obstructive Pulmonary Disease and HIV Infection in a Ugandan Population
(Makerere University, 2023-11-01)Background: The prevalence of chronic obstructive pulmonary disease (COPD) has increased among people living with HIV (PLWH) despite the global scale-up of antiretroviral therapy (ART). Currently, it is not fully known ... -
Diagnostic performance evaluation of lateral flow florescence immunoassay (LFIA)- based point-of-care platforms in the measurement of selected cancer makers; PSA, CEA and CA125
(Makerere University, 2023-11-14)Background: In Uganda, cancer diagnosis has been largely dependent on conventional methods such as histopathology. These methods although very accurate they however require specialized facilities with trained personnel ... -
Human Cytomegalovirus infection in febrile patients with hematological malignancies at Uganda Cancer Institute
(2017-11-14)Background: Sub-Saharan Africa is experiencing a marked increase in the burden of cancer-related morbidity and mortality, with more than 1 million incident cancers and nearly 800 000 cancer-related deaths projected annually ... -
Characterizing microbial diversity and resistome in urban sewage using shotgun metagenomics in Kampala, Uganda
(Makerere University, 2023-05)Introduction: Recently, antimicrobial resistant (AMR) infections have shown up as the leading threat to human health, having 700,000 directly attributed estimated deaths per year worldwide. For Africa, AMR data is still ... -
Genomic study of Klebsiella pnuemoniae from neonatal invasive, neonatal and maternal carriage at Kawempe National Referral Hospital, Uganda
(Makerere University, 2023-11-14)Neonatal infections particularly bloodstream infections (BSI) pose a significant health risk, necessitating a comprehensive understanding of the genetic characteristics of causative strains for effective treatment and ...
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