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Viral load and reverse transcriptase drug resistance mutations in HIV-1 isolated from mothers who transmit the virus to their infants at Kibagabaga Hospital PMTCT Clinic, Kigali, Rwanda
(Makerere University, 2014-09)
Mother to Child Transmission (MTCT) of HIV is the largest source of HIV infection in children below the age of 15 years, affecting five-million infants per year. HIV/AIDS is a disease with known modes of transmission and ...
Analysis of HIV-1 sub types among blood donors in Uganda using a multi-region hybridization assay.
(2008-04)
BACKGROUND:
Uganda has been a focus of HIV/AIDS intervention efforts, including vaccine clinical trials. HIV-1 genetic diversity poses challenges for design of efficacious vaccines. Data on HIV-1 genetic diversity is ...
Phenotypic characterisation of activated plasmacytoid dendritic cells among anti-retroviral therapy-naïve Ugandans with chronic HIV-1 clade A or D infection.
(Makerere University, 2011)
Plasmacytoid dendritic cells (pDC) are the most potent producers of interferon alpha (IFN-α) and tumor necrosis factor alpha (TNF-α) in response to enveloped viruses providing a critical link between the innate and adaptive ...
Blood and body fluid exposures among surgeons in Mulago hospital
(COSECSA/ASEA, 2011-11)
Background: It is now recognized that health workers are at risk of acquiring infection with hepatitis B virus (HBV), hepatitis C virus (HCV), HIV and other blood borne pathogens through contact with infected blood and ...
Relationship between plasma levels of stavudine and self reported adherence rates to triomune in HIV/AIDS patients at the Joint Clinical Research Centre, Mengo Uganda.
(2009)
INTRODUCTION:
Adherence to antiretroviral therapy is mainly assessed by patient self reporting method in Uganda. The relationship between self reported adherence rates and plasma drug levels is not known. This study sought ...
In silico prediction of efavirenz and rifampicin drug–drug interaction considering weight and CYP2B6 phenotype
(The British Pharmacological Society, 2010)
AIMS
This study aimed to test whether a pharmacokinetic simulation model
could extrapolate nonclinical drug data to predict human efavirenz
exposure after single and continuous dosing as well as the effects of
concomitant ...
HIV/AIDS patients display lower relative bioavailability of Efavirenz than healthy subjects
(Adis Data Information BV., 2011)
Background: Pharmacokinetic studies of antiretroviral drugs are often conducted in adult healthy subjects, and the results are extrapolated to HIV/AIDS patients. HIV/AIDS, however, is known to cause morphological and ...
Smart, nano-engineered drug (NRTI)-immune conjugates for targeting HIV within reservoirs
(BioMed Central, 2011-07-22)
Background: Infection with HIV, which culminates in the establishment of a latent proviral reservoir, presents formidable challenges for ultimate cure. Building on the hypothesis that ex-vivo or even in-vivo abolition or ...
Campylobacter spp among Children with acute diarrhea attending Mulago hospital in Kampala - Uganda
(2002-05)
Introduction HIV positive (HIV+) women are more susceptible to malaria infection during pregnancy than their HIV negative (HIV-) counterparts but the actual prevalence of infection in Ugandan pregnant women is not known. ...