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Extended automated NGS pipeline for reproducible analysis of mosquito genomes
(Makerere University, 2022-11)
Over the past decade, the decreasing costs of sequencing have facilitated the agnostic interrogation of vector genomes, giving access to an ever-expanding volume of high quality genomic and transcriptomic data. Today, the ...
Utility of urine LAM Biomarker for treatment response monitoring during 8 weeks of MDR-TB treatment at Mulago National Referral Hospital
(Makerere University, 2022-03)
Background: The current methods used in monitoring treatment response among MDR - TB patients have low sensitivity, take long to give results, are expensive and require BSL3 facilities. It is known that MTB LAM as a biomarker ...
Knowledge, attitudes and practice of ethics among plant agricultural researchers at the National Agricultural Research Laboratories, Kawanda-Uganda
(Makerere University, 2022-04-25)
Background: Plant agricultural research plays an important role and contributes significantly to human health and livelihood. With the current advancements in technology, this research is not exempt from ethical issues and ...
Characterizing the composition of the airway microbiota of patients with COPD in a rural setting in Uganda using shotgun metagenomics, a case control study
(Makerere university, 2022-10-25)
Introduction:
Diverse airway microbiota play an important role in the development and integrity of the immune system that limits growth of pathogenic microorganisms and clearing bacterial infections. Community shifts from ...
Comparative genomics of Staphylococcus aureus isolates from Africa using virulence and drug resistance markers
(Makerere University, 2022-08)
Introduction
There is wide diversity among Staphylococcus aureus lineages colonizing and infecting the African population, yet information on S. aureus infections in Africa is limited. Africa bears a particularly high ...
Genetic Diversity of Bundibugyo ebolavirus from Uganda and the Democratic Republic of Congo
(Makerere University, 2022-01-02)
Background
The Ebola virus is one of the deadliest known viral pathogens. It was first discovered in 1976 during two consecutive outbreaks in the Democratic Republic of Congo (DRC) and Sudan. Since then six known strains ...
Low-abundance drug resistant variant patterns among HIV-1 patients with virological failure in Uganda
(Makerere University, 2022-03)
Background: The emergence and spread of antiretroviral drug resistant HIV-1 variants is one
of the major factors responsible for therapeutic failure in persons living with HIV (PLWH) as
it jeopardizes the efforts to ...
Evaluation of the efficacy and safety of combining Carica Papaya Linn, Vernonia Amygdalina Delile, Artemisinin and Iodine as potential agents in the management of Breast Cancer
(Makerere University, 2021-12-25)
Background: Carica papaya Linn (CP), Vernonia amygdalina Delile (VA), dihydroartemisinin (DHA) and molecular iodine (I2) were reported to have antiproliferative and cytotoxic activities on breast cancer but their anticancer ...
In vitro activity of mycobacteriophages against Mycobacterium tuberculosis biofilms
(Makerere University, 2021-03)
Tolerance of Mycobacterium tuberculosis to antibiotics has been associated with its tendency to grow in cell aggregates known as biofilms. These biofilms consist of layers of cells covered by a lipid-rich extracellular ...
Developing an Automated Panel Design Tool for SNP-Based Targeted Amplicon Sequencing of Schistosoma mansoni Populations
(Makerere University, 2022-08-26)
Genomic surveillance of Schistosomiasis across endemic regions could provide insights into the efficacy of current control strategies and allow the impact of selection on the parasite genome to be monitored, providing early ...