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Reverse vaccinology and molecular docking as tools to identify potential vaccine candidates against drug-resistant Mycobacterium tuberculosis and Mycobacterium bovis
(Makerere University, 2022-03-29)
The emergence of multi-drug-resistant Mycobacterium tuberculosis (M.tb) and Mycobacterium bovis (M.bovis), the causative agents of Tuberculosis (TB) and zoonotic TB respectively are of significant threat to public health. ...
Role of vaginal microbiome in host susceptibility to HIV infection among pregnant Ugandan women: inflammatory response and epithelial barrier integrity
(Makerere University, 2021-10)
Background: Pregnant women are a key target population in the prevention of new HIV infections, and their protection can be extrapolated to their unborn children during pregnancy and at birth. The role of vaginal microbiota ...
Non-BRCA breast cancer predisposing variants identified in Kenyan patients using whole-exome sequencing
(Makerere University, 2022-07)
Background: Breast cancer is a leading cause of cancer-related mortality in women worldwide. This disease is reported to be associated with mutations in several predisposing genes in addition to the long known BRCA1/2. ...
Autopsy survey of histopathological features and immunohistochemical markers of dementia in medico-legal deaths at Mulago hospital and KCCA mortuaries, Uganda
(Makerere University, 2022-11-22)
Background: Dementia is a neurodegenerative disorder characterized by an irreversible
cognitive decline. Although previously associated with old age, in people aged 65 and above,
recent studies have reported early-onset ...
T cell Expression of CD153 in Latent Tuberculosis Infection and Type 2 Diabetes Mellitus
(Makerere University, 2022-06-22)
The increasing prevalence of latent tuberculosis among individuals with type 2 diabetes mellitus has increased the public health importance of TB and non-communicable diseases, yet the immune correlates of protection or ...
Metagenomic analysis of coronaviruses in bat fecal matter collected from a human-bat interface around Arua City, West Nile Region, Uganda
(Makerere University, 2022-10)
Background
Many recent disease outbreaks in humans had a zoonotic virus etiology. The ongoing coronavirus disease 2019 (COVID-19) pandemic has had devastating health and socioeconomic impacts. Bats are reservoirs for a ...
Expression of ARID1A in Penile Squamous Cell Carcinoma and its association with age, histological subtypes and grades in the Pathology Department, Makerere University.
(Makerere University, 2022-03)
Background: About ninety-five percent (95%) of penile carcer arise in the squamous epithelium, giving rise to squamous cell carcinoma. Worldwide, the incidence and global health burden of penile cancer is in the range of ...
Comparative genomics and antibiotic – resistance determinants of clinical pseudomonas aeruginosa isolates from Kenya
(Makerere University, 2022)
Pseudomonas aeruginosa is a leading cause of nosocomial infections worldwide. It causes a range of debilitating infections, have a propensity for developing antimicrobial resistance, and present with a variety of dangerous ...
Assessment of microbiological quality of herbal preparations used in the treatment of malaria, cough and HIV in Kampala district
(Makerere University, 2022-02)
In Uganda, herbal medicine is widely used in the treatment and prevention of various conditions including cough, malaria and HIV opportunistic infections. The demand for herbal products has increased among many consumers ...
Whole exome sequencing uncovers genetic predisposition to pediatric HIV disease progression and hyperhemolysis syndrome
(Makerere University, 2022-07)
Background: Populations of African ancestry hold a disproportionate burden of infectious and non-infectious diseases. Genetic variants, with population allele frequencies ranging from rare to common variants, are believed ...