School of Bio-Medical Sciences (Bio-Medical): Recent submissions
Now showing items 341-360 of 423
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Oral health promotion in schools: rationale and evaluation.
(Health Education, 2013)Purpose – The purpose of this paper is to explain the rationale and potential for the WHO health promoting schools (HPS) to improve children’s oral health, and describe validated quantitative methodologies and qualitative ... -
Relationship between phenotypic features of Cryptococcus Neoformans and CSF opening pressure in HIV–infected patients with cryptococcal meningitis in Mulago Hospital, Kampala, Uganda.
(Makerere University, 2012-05)Background: Cryptococcal meningoencephalitis(CM) is a highly prevalent HIV associated opportunistic infection in Africa, with mortality attributable to raised intracranial pressure (ICP) as high as 50%, rising to 100% among ... -
Species and antifungal susceptibility of Candida causing Vulvovaginal candidiasis among pregnant mothers attending the antenatal clinic at Mulago National Referral Hospital
(Makerere University, 2013-05)Background: Vulvovaginal candidiasis (VVC) is a fungal infection of the female lower genital tract- the vagina and vulva caused by candida species. It is estimated that 40% of healthy asymptomatic women have Candida as ... -
Prevalence and factors associated with intestinal helminths infestation and schistosoma mansoni among residents of Katosi fish landing site in Mukono District, Uganda
(Makerere University, 2012-06)Introduction: It is estimated that over one billion of the world’s population is chronically infested with intestinal helminths and these infestations are closely correlated to poverty, poor environmental hygiene and poor ... -
Patterns and predictors of self-medication in Northern Uganda
(PLOS One, 2014)Self-medication with antimicrobial agents is a common form of self-care among patients globally with the prevalence and nature differing from country to country. Here we assessed the prevalence and predictors of antimicrobial ... -
A metabolic biosignature of early response to anti-tuberculosis treatment
(BMC Infectious Diseases, 2014)Background: The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacterium ... -
Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic Falciparum Malaria Infections in Uganda
(Journal of Infectious Diseases, 2014)We explored associations between Plasmodium falciparum drug resistance–mediating polymorphisms and clinical presentations in parasitemic children enrolled in a cross-sectional survey in Tororo, Uganda, using a retrospective ... -
Post-market quality of Rifampicin containing fixed-dose combinations of anti-tuberculosis drugs in Kampala, Uganda
(Makerere University, 2010-08)Background: Tuberculosis (TB) is an important curable infectious disease in Uganda; its treatment however is facing a challenge of increasing drug resistance. Although Rifampicin containing Fixed-Dose Combination (R-FDC) ... -
How reliable are hematological parameters in predicting uncomplicated plasmodium falciparum malaria in an Endemic Region?
(Hindawi Publishing Corporation, 2013)Background. Malaria remains endemic in Sub-Saharan Africa. Hematological changes that occur have been suggested as potential predictors of malaria. This study was aimed at evaluating the diagnostic relevance of hematological ... -
Meta-analysis to compare the accuracy of GeneXpert, MODS and the WHO 2007 algorithm for diagnosis of smear-negative pulmonary tuberculosis
(BMC Infectious Diseases, 2013)Background: Smear-negative pulmonary tuberculosis (SN-PTB), which is common in HIV-infected patients, is difficult to diagnose using smear microscopy alone. In 2007, the WHO developed an algorithm to improve the diagnosis ... -
Elucidating emergence and transmission of multidrug-resistant tuberculosis in treatment experienced patients by whole genome sequencing
(PLOS One, 2013)Background: Understanding the emergence and spread of multidrug-resistant tuberculosis (MDR-TB) is crucial for its control. MDR-TB in previously treated patients is generally attributed to the selection of drug resistant ... -
Phenotypic characterisation of activated plasmacytoid dendritic cells among anti-retroviral therapy-naïve Ugandans with chronic HIV-1 clade A or D infection.
(Makerere University, 2011)Plasmacytoid dendritic cells (pDC) are the most potent producers of interferon alpha (IFN-α) and tumor necrosis factor alpha (TNF-α) in response to enveloped viruses providing a critical link between the innate and adaptive ... -
Prevalence and genotypic analysis of entamoeba histolytica isolates from Soroti by RFLP of serine-rich entamoeba histolytica protein gene locus
(Makerere University, 2012-11)Amoebiasis is an infection caused by water borne protozoan parasite Entamoeba histolytica. In Uganda where sanitation infrastructure and health education is not adequate, amoebiasis is still an important health problem. ... -
Cotrimoxazole Prophylaxis specifically selects for Cotrimoxazole resistance in Streptococcus mutans and Streptococcus sobrinus with varied Polymorphisms in the target genes folA and folP
(Hindawi Publishing Corporation, International Journal of Microbiology, 2012)The selection of antibiotic resistance by cotrimoxazole prophylaxis was evaluated, and we characterized the mechanism of cotrimoxazole resistance in Streptococcus mutans and Streptococcus sobrinus. In vitro susceptibility ... -
Bacteriological quality analysis of herbal cosmetics sold in Kampala District, Uganda
(Makerere University, 2011-07)The use of herbal cosmetics is popular in Uganda. Despite the increase in consumer trust for these products, the bacteriological quality of herbal cosmetics sold in Kampala has remained unknown. Regulatory polices on herbal ... -
Quality of Sulfadoxine-pyrimethamine (SP) tablets sold in drug outlets in Arua District, Uganda
(Makerere University, 2010-09)Background: Sulfadoxine-pyrimethamine (SP) remain a corner stone in intermittent preventive treatment (IPT) of malaria in pregnancy. Reports of substandard and counterfeit antimalarial drugs in Uganda and neighbouring ... -
Asymptomatic Bacteriuria in Diabetic patients attending Mulago Hospital
(Makerere University, 2010-08)Introduction There are about 285 million people currently living with Diabetes Mellitus (DM) and the number is expected to reach 438 million in 2030. Intensive management of DM reduces microvascular complications by about ... -
Attitudes and knowledge gaps of the communities about cervical carcinoma and it’s detection in four selected districts of Uganda
(INABSTA, 2007)The main objective of the study was to determine the attitudes and knowledge gaps about cervical carcinoma in the urban and rural women and health workers. A cross sectional study survey was done on four districts of ... -
Viridans streptococci group: Antibiotic susceptibility profiles, cotrimoxazole prophylaxis and the molecular basis of cotrimoxazole resistance in Uganda
(Makerere University, 2012)This thesis is about studies on the viridians streptococci group (VSG). It focused on two main bacterial species groups, the mutans and the mitis groups of commensal bacteria, which are commonly neglected. These bacteria ... -
Combined antiretroviral treatment modification among HIV infected patients in New Nyanza Provincial General Hospital, Western Kenya
(2012-06)Background Limited combined antiretroviral therapy (cART) regimens in resource constrained settings call for the need to optimize the available options in order to improve the durability of potent and well-tolerated first ...