School of Bio-Medical Sciences (Bio-Medical): Recent submissions
Now showing items 201-220 of 423
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Translocation of rectal flora and its role in pathogenesis of septicemia in children with severe acute malnutrition
(Makerere University, 2018-12-06)Introduction: Childhood under-nutrition alters gut mucosal permeability and architecture, causing movement of organisms from GIT into circulation. Most studies carried have detailed bacteremia with malnutrition but none ... -
Molecular epidemiology of antimicrobial resistance at a human-animal interface in pastoralist community of Kasese District, Uganda
(Makerere University, 2021-04)Background: Intensive usage of antimicrobials in the management of animal diseases may cause selection for resistance among microorganisms. Transmission of resistant bacteria from the wild and domestic food animals to ... -
Host genetic variations and their association with malaria among Ugandan children
(Makerere University, 2021-04)This thesis comprises studies of the relationship between host genetic factors and incidence of uncomplicated malaria in a vaccine trial site in Iganga district. The studies focused on selected host gene markers that are ... -
Research participants’ perspectives on compensation for participation in biomedical research in cancer patients at Uganda Cancer Institute
(Makerere University, 2021-04-09)Background: Compensation of research participants in health-related research is a common practice that has existed globally for the last 100 years but is implemented differently in diverse research settings basing on generic ... -
Prevalence of immune non-response to Hepatitis B virus vaccine among secondary school students in Kumi district, Eastern Uganda
(Makerere University, 2021-05-11)Background: Hepatitis B virus is still a silent killer disease in Ugandan communities, particularly in high burdened regions. Despite Government initiative for mass vaccination program for those areas, there has been ... -
Evaluation of stool with sputum DNA on FTA card, microscope slide and TB-Lamp for Mycobacterium Tuberculosis detection using Xpert MTB/Rif (Xpert) as Gold standard among Pulmonary Tuberculosis patients
(Makerere University, 2021-04-19)The Xpert MTB/RIF (Xpert) and TB-Lamp assay technology allows rapid and sensitive diagnosis of pulmonary tuberculosis (PTB) from sputum specimens. The conventional plastic sputum containers allow transportation of sputum ... -
M. Tuberculosis 85b messenger ribonucleic acid as a biomarker for treatment response among multidrug resistant tuberculosis patients attending Mulago hospital, Uganda
(Makerere University, 2021-04-28)Background: The occurrence of multidrug resistance (MDR) is one of the major bottlenecks to TB elimination. This is worsened by the lack of reliable point of care (POC) tests for monitoring MDR TB patients with viable M. ... -
Effect of mixed mycobacterium tuberculosis infection on the performance of rapid molecular diagnostic test among patients initiating MDR-TB treatment at Mulago National TB treatment
(Makerere University, 2021-04-26)Introduction: Performance of rapid molecular diagnostic test in detecting drug resistant Mycobacterium tuberculosis (MTB) is key in controlling the infection and treatment response of TB. Presence of mixed MTB infection ... -
Stakeholders perceptions and experiences regarding research at Makerere University College of Health Sciences
(Makerere University, 2021-02-17)The study purposed to explore the perceptions and experiences of key research stakeholders at Makerere College of Health Sciences (MaKCHS) and affiliate research institutions. Several research studies conducted at the ... -
Evaluation of quality of hepatitis B vaccines circulating on the Ugandan market
(Makerere University, 2021-04-28)Vaccination is the greatest public health intervention in these modern times. Since the Ministry of Health -Uganda rolled out the Hepatitis B vaccination program, there has been a continuous decrease in the number of new ... -
Detection of Leishmania in human blood and tissue exudate ingested by Tunga penetrans
(International Scholars Journals, 2020-09)Communities in Uganda are experiencing a multiparasitism, blood microscopy often reveals Leishmania and microfilaria in patients with anaemia, haemorrhage and splenomegaly. Many are likely asymptomatic and probably exposed ... -
Evaluation of hepatitis b surface antigen (hbsag) as a surrogate marker for hepatitis b viral load estimation.
(Makerere University, 2021-04-28)Background: A Hepatitis B Virus (HBV) viral load measurement is recommended for diagnosis and monitoring of patients on treatment for Chronic Hepatitis B (CHB). However, these diagnostic techniques are molecular-based ... -
T- cell activation and senescence phenotypes among people living with hiv-1 with advanced immunosuppression
(Makerere University, 2021-04-29)INTRODUCTION. T cell activation and senescence phenotype markers among HIV-1 infected patients with advanced immunosuppression are key components in the immunopathogenesis of HIV. In HIV infection, senescence is accelerated ... -
Diagnostic accuracy of various hepatitis c rapid tests against elisa in detection of hepatitis c infection.
(Makerere University, 2021-03-25)INTRODUCTION: HCV is one of the leading causes of liver disease in the world with over 71 million people infected and in Uganda, HCV sero-prevalence estimates range from 0.0% to 14.6%. It is predominantly a blood borne ... -
Vancomycin Resistance among Methicillin Resistant Staphylococcus aureus Isolates in Uganda.
(Makerere University, 2021-04-01)Introduction Methicillin resistant Staphylococcus aureus is defined as Staphylococcus aureus strain resistant to almost all Beta-lactams antimicrobial agents. The increased burden of methicillin resistant Staphylococcus ... -
Compensating health research participants : Research Ethics Committee members’ perspectives and ethical guidance
(Makerere University, 2020-06-25)Background: Research participants in resource-poor settings face a risk of exploitation due to widespread poverty and their limited experience and understanding of research. Researchers have an obligation to protect research ... -
Exploring the disclosure of risks and benefits of depo-provera by health care workers at public health facilities in Kyotera and Rakai districts
(Makerere University, 2021-02-22)Background: Contraception is a basic human right for all women as articulated in the Universal Declaration of Human Rights. Every girl and woman should have the right to choose what contraception method, when they want, ... -
Role of Killer-cell Immunoglobulin-like Receptors and Human Leukocyte Antigens in Transmission and Severity of Malaria in Uganda
(Makerere University, 2021-04-08)Background Malaria is a life-threatening disease caused by Plasmodium falciparum. In 2018, there were an estimated 228 million cases of malaria worldwide and 405,000 malaria deaths. Malaria burden is greatly affected by ... -
Motivation to participate in HIV/AIDS clinical trials among trial participants at joint clinical research centre, Lubowa, Wakiso district, Uganda
(Makerere University, 2021-03-10)Background: Participation from diverse population groups in clinical trials is important but also, allowing voluntary decision making is equally important. To understand the dynamics of decision-making, contextual focus ... -
Sputum microRNA profiles of treatment-naïve and patients on antituberculosis therapy in Mulago National Referral Hospital
(Makerere University, 2021-03-29)Background: Worldwide, tuberculosis (TB) is the leading cause of death due to a single infectious agent. This is attributed to the limitations of the current diagnostic tests in terms of sensitivity and specificity. ...