Search
Now showing items 1-10 of 11
Blood and body fluid exposures among surgeons in Mulago hospital
(COSECSA/ASEA, 2011-11)
Background: It is now recognized that health workers are at risk of acquiring infection with hepatitis B virus (HBV), hepatitis C virus (HCV), HIV and other blood borne pathogens through contact with infected blood and ...
Smart, nano-engineered drug (NRTI)-immune conjugates for targeting HIV within reservoirs
(BioMed Central, 2011-07-22)
Background: Infection with HIV, which culminates in the establishment of a latent proviral reservoir, presents formidable challenges for ultimate cure. Building on the hypothesis that ex-vivo or even in-vivo abolition or ...
In silico prediction of efavirenz and rifampicin drug–drug interaction considering weight and CYP2B6 phenotype
(The British Pharmacological Society, 2010)
AIMS
This study aimed to test whether a pharmacokinetic simulation model
could extrapolate nonclinical drug data to predict human efavirenz
exposure after single and continuous dosing as well as the effects of
concomitant ...
HIV/AIDS patients display lower relative bioavailability of Efavirenz than healthy subjects
(Adis Data Information BV., 2011)
Background: Pharmacokinetic studies of antiretroviral drugs are often conducted in adult healthy subjects, and the results are extrapolated to HIV/AIDS patients. HIV/AIDS, however, is known to cause morphological and ...
Phenotypic characterisation of activated plasmacytoid dendritic cells among anti-retroviral therapy-naïve Ugandans with chronic HIV-1 clade A or D infection.
(Makerere University, 2011)
Plasmacytoid dendritic cells (pDC) are the most potent producers of interferon alpha (IFN-α) and tumor necrosis factor alpha (TNF-α) in response to enveloped viruses providing a critical link between the innate and adaptive ...
Viral load and reverse transcriptase drug resistance mutations in HIV-1 isolated from mothers who transmit the virus to their infants at Kibagabaga Hospital PMTCT Clinic, Kigali, Rwanda
(Makerere University, 2014-09)
Mother to Child Transmission (MTCT) of HIV is the largest source of HIV infection in children below the age of 15 years, affecting five-million infants per year. HIV/AIDS is a disease with known modes of transmission and ...
Relationship between phenotypic features of Cryptococcus Neoformans and CSF opening pressure in HIV–infected patients with cryptococcal meningitis in Mulago Hospital, Kampala, Uganda.
(Makerere University, 2012-05)
Background: Cryptococcal meningoencephalitis(CM) is a highly prevalent HIV associated opportunistic infection in Africa, with mortality attributable to raised intracranial pressure (ICP) as high as 50%, rising to 100% among ...
Combined antiretroviral treatment modification among HIV infected patients in New Nyanza Provincial General Hospital, Western Kenya
(2012-06)
Background
Limited combined antiretroviral therapy (cART) regimens in resource constrained settings call for the need to optimize the available options in order to improve the durability of potent and well-tolerated first ...
Tenofovir related renal toxicity monitoring in antiretroviral therapy (ART) accredited sites: A situational analysis for Uganda
(Makerere University, 2014-09)
Background: In Uganda, Tenofovir-based regimen is recommended as first line particularly for HIV/AIDS adult and adolescent patient and for option B+ in prevention of mother-to-child transmission (PMTCT). As a result of ...
Growth patterns and survivability of the different mycobacterium tuberculosis sub lineages predominant in peri urban Kampala
(Makerere University, 2014-05)
Background: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB) infects over 2 billion people world-wide with the vast majority of deaths from TB in the developing world. Strains of MTB vary in ...