School of Bio-Medical Sciences (Bio-Medical): Recent submissions
Now showing items 61-80 of 423
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Assessment of biosafety and biorisk management practices among medical laboratory students in two institutions in Uganda
(Elsevier, 2022)Medical laboratory workers handle clinical specimens, which are a threat of exposure to infectious agents. Notably, medical laboratory science students report for internships with only theoretical knowledge of biosafety ... -
Status of pulmonary fungal pathogens among individuals with clinical features of pulmonary tuberculosis at Mbarara University Teaching Hospital in Southwestern Uganda
(Therapeutic advances in infectious disease, 2021)Background: Pulmonary mycoses are important diseases of the respiratory tract caused by pulmonary fungal pathogens. These pathogens are responsible for significant morbidity and mortality rates worldwide; however, less ... -
Investigating Metabolic and Molecular Ecological Evolution of Opportunistic Pulmonary Fungal Coinfections: Protocol for a Laboratory-Based Cross-Sectional Study
(JMIR, 2023-12)Background: Fungal-bacterial cocolonization and coinfections pose an emerging challenge among patients suspected of having pulmonary tuberculosis (PTB); however, the underlying pathogenic mechanisms and microbiome ... -
Plasmodium falciparum genetic diversity and multiplicity of infection based on msp‑1, msp‑2, glurp and microsatellite genetic markers in Sub-Saharan Africa: a systematic review and meta-analysis
(BMC, 2024)Background In sub-Saharan Africa (SSA), Plasmodium falciparum causes most of the malaria cases. Despite its crucial roles in disease severity and drug resistance, comprehensive data on Plasmodium falciparum genetic ... -
A comparison of frequencies and function of myeloid derived suppressor cells (MDSCS) IN TB/HIV co-infected and HIV mono-infected individuals in Uganda
(Makerere University, 2023)Background Myeloid-derived suppressor cells (MDSC) encompass a subset of myeloid cells, which suppress both innate and adaptive immune functions. These cells negatively regulate the immune function either by arginine ... -
Sero-antigen prevalence of lymphatic filariasis and risk factors of podoconiosis in Busiriba Sub-county, Kamwenge District, Southwestern Uganda, August–September 2018
(BMC, 2024)Objective Given the neglected nature of filariasis, especially in Uganda where data are scarce, this cross-sectional study aimed to determine the sero-antigen prevalence of lymphatic filariasis and risk factors associated ... -
Incidence and etiology of catheter associated urinary tract infection among admitted patients at Kabale Regional Referral Hospital, South Western Uganda
(Scientific Research Publishing, 2019)Introduction: Catheter Associated Urinary Tract Infection is the most common hospital acquired infection worldwide. Urinary Tract Infections among catheterised patients are on rise regardless of antibiotic use and this is ... -
Clindamycin resistance among methicillin resistant staphylococcus aureus isolated from human and respective household swine in greater Kabale Region—South Western Uganda
(Scientific Research Publishing, 2019)Introduction: S. aureus is recognized as the common cause of nosocomial and community-acquired infections. Macrolide-Lincosamide-Streptogramin B (MLSB) is thought to be alternative therapies against MRSA infections. Clindamycin ... -
Functioning and control of phagocytosis
(IntechOpen, 2023)Phagocytosis is a very complex and versatile process that contributes to immunity through a series of events that is it’s sometimes referred to the Come and Eat me process. Due to the recognition ingestion and digestion ... -
Laboratory Diagnosis of Candidiasis
(IntechOpen, 2022-08)The burden of Candidiasis continues to increase and so does the Candida species. Although Candida species are closely similar phenotypically, they differ from each other in terms of epidemiology, genetic characteristics, ... -
Diversity and distribution of Spa Types among Methicillin resistant staphylococcus aureus isolated from humans and livestock in Kabale District - South Western Uganda
(Journal of Veterinary Health Science, 2022)Background: S. aureus is a skin and mucosal bacterial commensal of both humans and animals which has evolved as an important pathogen implicated to cause various infections. High levels of antibiotic use have resulted into ... -
Detection of clinically relevant respiratory viruses and their temporal dynamics in sputum of tuberculosis patients on anti-TB drugs at Naguru Hospital, Kampala, Uganda
(Makerere University, 2024)Background Tuberculosis is one of the leading infectious causes of death in the world, with nearly 10 million new cases diagnosed each year, resulting into an estimated 1.3 million deaths(1). The relationship between M. ... -
Antimicrobial stewardship practices and quality of antibacterial use in children under five and women in labour with obstetric risk factors in selected health facilities in Uganda
(Makerere University, 2024)Introduction Bacterial infections are a leading cause of morbidity and mortality in Ugandan hospitalised children under the age of five. Disparities exist in using antibacterial agents to treat bacterial infections at ... -
Detection of mycobacterium tuberculosis complex DNA in CD34 positive versus CD34-Negative peripheral blood mononuclear cells and the determinants of IGRA positivity in latent Tuberculosis
(Makerere University, 2023)Background Tuberculin skin test (TST) and interferon gamma release assay (IGRA), currently used to diagnose latent tuberculosis infection (LTBI) have low positive predictive values for progression to active tuberculosis ... -
A machine learning approach to predict E. coli antibacterial resistance using whole-genome sequencing data
(Makerere University, 2023)Background: Antimicrobial resistance (AMR) is a significant global health threat, particularly impacting low- and middle-income countries(LMICS) such as Uganda, where reliable and rapid methods for detecting AMR in E. coli ... -
Transcriptome analysis of micro-RNAs associated with COVID-19 disease
(Makerere University, 2023-11)The host microRNA (miRNA), which is essential for maintaining the epithelial cell barrier in the respiratory tract as well as controlling viral entry and reproduction, plays a significant role in COVID-19 infection. ... -
Evaluation of the efficacy of fresh Saccharum officinarum linn goa (var) stem juice against aspirin-induced ulcers in wistar albino rats.
(Makerere University, 2023-08)Back ground: In Uganda, 12% to 25% of the population is living with peptic ulcer disease. Efforts to treat the disease have become much more difficult due to rising prevalence of drug resistance, unbearable adverse drug ... -
Characterization of performance of three commercial monoclonal antibodies in detection of spike protein in SARS-CoV-2
(Makerere University, 2024)The study aimed at characterizing the Performance of three commercial monoclonal antibodies in detection of spike protein in SARS-CoV-2. This was looking at avidity and specificity of the monoclonal antibodies which would ... -
Effects of locally made double – layered cloth face masks on exercise performance and cardiopulmonary parameters during physical activity in healthy adults
(Makerere University, 2023)Background: Due to the COVID–19 pandemic, cloth facemasks are used worldwide as a major prevention method against the spread of the disease, keeping dust away from the respiratory tract and avoiding acquiring other respiratory ... -
Reported adverse drug reactions of antiretroviral therapy generic formulations in Uganda
(Makerere Univesrity, 2023)Background: Generic Antiretroviral drugs are commonly used in the developing countries and this has greatly contributed to the scaling up of ART. Generics vary in formulation including excipients, the production conditions ...