School of Bio-Medical Sciences (Bio-Medical): Recent submissions
Now showing items 21-40 of 423
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Model-based prediction of Dolutegravir dose requirement for HIV exposed neonates in Uganda
(Makerere University, 2024)Introduction: Mother-to-child transmission of HIV is the primary source of HIV infections in children, especially in low-income countries accounting for 14% of all new infections in Uganda. It is recommended that HIV-exposed ... -
Microbial environmental contamination and infection prevention and control practices in the maternity ward of Buwenge General Hospital
(Makerere University, 2024)A 2017 review found that 42.6% of African countries lacked adequate antimicrobial resistance data, with widespread resistance among clinical isolates. In Uganda, despite IPC guidelines, healthcare workers often lack ... -
Evaluation of anticonvulsant activity of the aqueous and total crude extracts of Vernonia amygdalina Delile in pentylenetetrazole-induced seizures in wistar albino rats
(Makerere University, 2024-11-07)Introduction: Seizures due to abnormal electrical activity in the brain leading to convulsions and hence epilepsy have continued to be a serious problem among the population globally including in Uganda. Medicinal plants ... -
Microbiome-induced immune resistance to mycobacterium tuberculosis at the Airway Mucosa
(Makerere University, 2024)Rationale: Mycobacterium tuberculosis (M.tb) remains one of the deadliest infectious pathogens globally. Amidst efforts to control the disease, challenges such as long treatment duration, drug toxicity, and resistance ... -
A comparison of Ubiquitin E3 ligases as surrogate markers for T cell Anergy in active TB
(2024-10-24)Background: Globally, there is an estimated 1.2 million TB-related deaths among HIV-negative people with active TB. Previous studies using ex-vivo and animal models indicate that CD4+ T cell unresponsiveness to Mtb, which ... -
Health profession students' awareness and perspectives on patients' rights
(Makerere University, 2024)Introduction: The concept of human rights in patient care refers to the theoretical and practical application of general human rights. It is universally acknowledged that all human beings possess individual and social ... -
Deciphering Rifampicin resistance among Tuberculosis patients who have trace and indeterminate results on Xpert MTB/RIF ultra assay
(Makerere University, 2024-10-22)Although WHO endorsed the GeneXpert test as the first initial test for Tuberculosis diagnosis, some of the GeneXpert Ultra results include MTB detected trace, RIF resistance indeterminate which necessitates a sample rerun, ... -
Evidence of molecular adaptive evolution of SARS-CoV-2 in Uganda using whole genome sequences
(Makerere University, 2024-10)Background: Seasonal influenza and coronaviruses both exhibit continual adaptive evolution during endemic circulation in the human population. The rapid evolution of human pathogenic RNA viruses can undermine the efforts ... -
Selected bacterial etiology of acute diarrhea in under five children at Mulago National Referral Hospital Kampala, Uganda.
(Makerere University, 2024-10)Background: Diarrhea is understood as the passing of three or more passages of loose or watery stools per day according to WHO and is considered among the major causes of childhood mortality and morbidity. Diarrhea kills ... -
Prevalence, associated risk factors, and consequences of medication errors in poultry practice in Wakiso district
(Makerere University, 2024)Medication errors are a serious health challenge in both humans and animals including in poultry practice in Uganda. However, limited information exists on the extent of burden of medication errors, risk factors and its ... -
Understanding genetic diversity and rapid drug resistance prediction in mycobacterium tuberculosis from whole-genome sequence and other epidemiological data
(Makerere University, 2024-06)Tuberculosis (TB) remains one of the major global health problems with an estimated 1.6 million deaths worldwide. The availability of whole-genome sequence (WGS) data offers a good avenue for understanding genetic diversity ... -
Antinociceptive activity and acute toxicity profile of Leucus calostachys olive in animal models
(Makerere university, 2024-11)Pain remains a cardinal sign and symptom for most diseases and a major reason for patients visiting healthcare providers. Conventional treatment modalities do not adequately address pain, and as a result, most local ... -
Evaluation of hypoglycemic activity, phytochemical composition and acute toxicity of Opuntia humifusa Raf. cladode extracts in Wistar albino rats
(Makerere University, 2024-10-29)Background Local communities in Central Uganda are using the cladodes of Opuntia humifusa in the treatment of diabetes mellitus with the claim that the plant is effective. However, efficacy and safety of the plant is not ... -
Performance evaluation of truenat test for detection of pulmonary tuberculosis among HIV symptomatic patients at Lira Regional Referral Hospital
(Makerere University, 2024)Background: About a quarter of the world’s population has been infected with Mycobacterium tuberculosis, in immune compromised people like in HIV- infected persons, the risk of developing tuberculosis is 22 times higher. ... -
Effect of substitution mutations on the temporal dynamics of HIV-1 subtype A1 and D in the Ugandan epidemic
(Makerere University, 2024)Background: Subtypes A1, D and inter-subtype recombinants dominate the Uganda HIV-1 epidemic. This diversity has affected disease diagnosis and therapeutics. Predictive modeling could guide better understanding of the ... -
Identification of unique molecular signatures in the envelope Glycoproteins of HIV-1 transmitted/founder viruses from East Africa
(Makerere University, 2024)Background: HIV-1 mucosal transmission undergoes a genetic bottleneck that allows a single virus termed HIV-1 Transmitted/Founder (T/F) virus to establish a productive clinical infection in most heterosexual transmission ... -
Characterization of ESBL producing gram negative uropathogenic bacteria isolated from patients with urinary yract infections from Mbeya, Tanzania
(Makerere University, 2024)Background: The emergence and spread of drug-resistant pathogens, such as ESBL-producing Gram-negative bacteria continue to threaten our ability to treat common infections causing a huge burden to our healthcare systems. ... -
Development of an antigen capture ELISA for detection of SARS-CoV-2
(Makerere University, 2024)Background. In December 2019, the World Health Organization (WHO) declared COVID-19 a global pandemic causing over 700 million cases and more than 7 million deaths globally. In Uganda, over 40,408 cases with 334 deaths ... -
Methicillin resistant staphylococcus on inanimate objects in paediatric treatment units of Mulago National Referral Hospital
(Makerere University, 2024)Background: Hospital environment and inanimate surfaces have been reported to be colonised by different pathogens. Contact with colonised objects may lead to pathogen transmission resulting in increased morbidity and ... -
Replication, fine-mapping and causal inference of genetic loci associated with major depressive disorder among participants of the Uganda genome resource.
(Makerere University, 2024-10-17)Background: Major depressive disorder (MDD) is the leading cause of disability worldwide, with significant consequences like poor health outcomes, premature death, and reduced productivity. Twin-based studies have shown ...