School of Bio-Medical Sciences (Bio-Medical): Recent submissions
Now showing items 1-20 of 352
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Detection of clinically relevant respiratory viruses and their temporal dynamics in sputum of tuberculosis patients on anti-TB drugs at Naguru Hospital, Kampala, Uganda
(Makerere University, 2024)Background Tuberculosis is one of the leading infectious causes of death in the world, with nearly 10 million new cases diagnosed each year, resulting into an estimated 1.3 million deaths(1). The relationship between M. ... -
Antimicrobial stewardship practices and quality of antibacterial use in children under five and women in labour with obstetric risk factors in selected health facilities in Uganda
(Makerere University, 2024)Introduction Bacterial infections are a leading cause of morbidity and mortality in Ugandan hospitalised children under the age of five. Disparities exist in using antibacterial agents to treat bacterial infections at ... -
Detection of mycobacterium tuberculosis complex DNA in CD34 positive versus CD34-Negative peripheral blood mononuclear cells and the determinants of IGRA positivity in latent Tuberculosis
(Makerere University, 2023)Background Tuberculin skin test (TST) and interferon gamma release assay (IGRA), currently used to diagnose latent tuberculosis infection (LTBI) have low positive predictive values for progression to active tuberculosis ... -
A machine learning approach to predict E. coli antibacterial resistance using whole-genome sequencing data
(Makerere University, 2023)Background: Antimicrobial resistance (AMR) is a significant global health threat, particularly impacting low- and middle-income countries(LMICS) such as Uganda, where reliable and rapid methods for detecting AMR in E. coli ... -
Transcriptome analysis of micro-RNAs associated with COVID-19 disease
(Makerere University, 2023-11)The host microRNA (miRNA), which is essential for maintaining the epithelial cell barrier in the respiratory tract as well as controlling viral entry and reproduction, plays a significant role in COVID-19 infection. ... -
Evaluation of the efficacy of fresh Saccharum officinarum linn goa (var) stem juice against aspirin-induced ulcers in wistar albino rats.
(Makerere University, 2023-08)Back ground: In Uganda, 12% to 25% of the population is living with peptic ulcer disease. Efforts to treat the disease have become much more difficult due to rising prevalence of drug resistance, unbearable adverse drug ... -
Characterization of performance of three commercial monoclonal antibodies in detection of spike protein in SARS-CoV-2
(Makerere University, 2024)The study aimed at characterizing the Performance of three commercial monoclonal antibodies in detection of spike protein in SARS-CoV-2. This was looking at avidity and specificity of the monoclonal antibodies which would ... -
Effects of locally made double – layered cloth face masks on exercise performance and cardiopulmonary parameters during physical activity in healthy adults
(Makerere University, 2023)Background: Due to the COVID–19 pandemic, cloth facemasks are used worldwide as a major prevention method against the spread of the disease, keeping dust away from the respiratory tract and avoiding acquiring other respiratory ... -
Reported adverse drug reactions of antiretroviral therapy generic formulations in Uganda
(Makerere Univesrity, 2023)Background: Generic Antiretroviral drugs are commonly used in the developing countries and this has greatly contributed to the scaling up of ART. Generics vary in formulation including excipients, the production conditions ... -
Exploring clinical ethics consultation experiences at Uganda Cancer Institute: version 11
(Makerere University, 2023-11)Background: Globally, healthcare providers (HCPs), hospital administrators, as well as patients and their caretakers are increasingly being confronted with complex moral, social, cultural, ethical and legal dilemmas during ... -
Informed consent knowledge, experiences and perspectives among clients receiving non-surgical healthcare services at Mulago National Referral Hospital
(Makerere University, 2023)Background: In medical ethics, healthcare providers have a moral obligation to ensure that all information about the patient’s condition and any proposed procedures are communicated and that the patient is not harmed. This ... -
Artemether-Lumefantrine Plasmodium Falciparum clearance and associated factors among uncomplicated Malaria patients in Adjumani District, Uganda
(Makerere University, 2023)The development of artemisinin resistance threatens the efforts to global malaria control. Artemisinin resistance has been reported in Northern Uganda and some African countries. Considering both host and parasite genetic ... -
Molecular subtypes, risk factors and survival of colorectal adenocarcinoma patients in Uganda
(Makerere University, 2023-06-26)Introduction: In Uganda, there has been a gradual increase in the burden of colorectal cancer (CRC) in the last decades. CRC is presenting at a young age, late stage, and runs an aggressive course. Understanding the reasons ... -
Awareness and perception of patients rights in clinical services among clients attending the outpatients department at Mawenzi Regional Referral Hospital, Tanzania
(Makerere University, 2023-10)Background: Patient rights are those owed to the patient as a human being, by physicians, healthcare workers, and by the state. Without the appropriate understanding of the patient’s rights, the healthcare team may at times ... -
The ethicality of mandatory COVID-19 vaccinations in Uganda: A qualitative study
(Makerere University, 2023-10)Background: COVID-19 spread globally and caused greater than 3.9 million deaths worldwide. Approximately 2.8 billion doses of COVID-19 vaccines were administered worldwide. Some studies suggested that vaccination was the ... -
Mycobacterium tuberculosis associated immune activation, inhibition and exhaustion profiling to predict active tuberculosis disease among presumptive tuberculosis participants and monitor anti-tuberculosis treatment response.
(Makerere University, 2023)Globally, tuberculosis (TB) is the leading cause of mortality and morbidity especially among resource-limited populations including Uganda. This statistic is greatly fueled by the delay in diagnosis of the disease and ... -
Stakeholders’ knowledge, perspectives and willingness to donate solid organs and associated ethical concerns in Uganda: a case study of Kampala
(Makerere University, 2023-11)Background The demand for human organs globally is higher than the supply. The government has enacted The Uganda Human Organ Donation and Transplant Act, 2022 aimed at regulating organ donation and transplant activities. ... -
HLA Class I and Pediatric HIV disease progression in Botswana and Uganda
(Makerere University, 2023)Sub-Saharan Africa remains the global epicenter of the HIV epidemic; more than 70% (25 million) of all people living with HIV/AIDS are in Africa. To end the global epidemic, finding an effective HIV vaccine remains a top ... -
Genetic determinants of differential susceptibility to hepatitis B Infection among a general population cohort from southwestern Uganda: a genome-wide association study
(Makerere University, 2023-11)Introduction: Hepatitis B is one of the major causes of mortality and morbidity worldwide. Hepatitis B infection causes liver inflammation and damage that may progress to liver cirrhosis, liver cancer and ultimately lead ... -
Molecular identification of fungal species associted with Mycetoma in Uganda.
(Makerere University, 2023-12-12)Background: Designated by the World Health Organization (WHO) as a neglected tropical disease (NTD), mycetoma is a chronic subcutaneous fungal and bacterial disease which causes profound morbidity. Mycetoma is mostly not ...