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GENETIC VARIATIONS WITHIN THE CCR5 PROMOTER REGION AMONG ELITE AND VIREMIC CONTROLLERS IN UGANDA
(2019-11-13)
Background: Mechanisms for HIV control among elite and viremic controllers are not fully understood. Although studies conducted in Uganda have reported the existence of these controllers, research has not yet sounded out ...
Comparison of Ackers culture to Inpouch culture for the diagnosis of Trichomonas vaginalis among Symptomatic Females at Mulago Hospital
(Makerere university, 2015-10)
Background: Trichomoniasis is the most curable sexually transmitted Infection (STI) in the world, caused by the genital Trichomonas vaginalis infection. The Trichomona vaginalis is a single celled flagellated eukaryote ...
Prevalence and Incidence of Carriage of Carbapenem Resistant Enterobacteriaceae among Patients Admitted to Mulago Hospital General Intensive Care Unit
(Makerere university, 2019-09-01)
Background: Carbapenem Resistant Enterobacteriaceae CRE) are among the major causes of nosocomial infections contributing to increase morbidity and mortality in the ICU. Carbapenem being the last choice of beta lactams for ...
Compensatory mutations in rpoA, rpoC and rpoD genes among rifampicin-resistant Mycobacterium tuberculosis isolates from Uganda
(Makerere University, 2019-11-11)
Background; Mycobacterium tuberculosis can acquire resistance to rifampicin through mutations in the rpoB gene. This is normally accompanied by the fitness cost which however can be mitigated by the acquired secondary ...
The sputum microbiome composition in pulmonary TB patients and its changes through TB treatment.
(Makerere University, 2018-12-02)
Background: Commensal microbiota residing in or on the human body play key roles in maintaining health and immunity. The abundance and dynamics of these microbial communities when disrupted can result in dysbiosis and the ...
Effects of Mycobacterium tuberculosis on B cell responses.
(Makerere University, 2018-11-04)
Background
Mycobacterium tuberculosis (M.tb) causes tuberculosis (TB), the leading cause of death from a single pathogen. The success of this microbe has been linked to its subversive effects on host immunity. Indeed, ...
AN ASSESSMENT OF UNDERSTANDING OF INFORMATION PROVIDED IN GENETIC RESEARCH AMONG PEOPLE LIVING WITH HIV AT THE INFECTIOUS DISEASES INSTITUTE (IDI)
(Makerere University, 2019-07)
Introduction
Obtaining informed consent is essential for biomedical research; and for informed consent to be valid, it is imperative that participants understand all the information disclosed to them before making voluntary ...
Evaluation of the impact of HIV-1 infections on Cytomegalovirus Specific T cells responses
(Makerere University, 2019-10-30)
Background: Incomplete understanding of the effect of HIV-1 infection on T cell immune response to HCMV is a barrier to development of better control strategies for HCMV infection in HIV-1 infected individuals. Depletion ...
INNATE IMMUNE SYSTEM RECOVERY AFTER LONG TERM ANTIRETROVIRAL THERAPY IN AN AFRICAN COHORT
(Makerere University, 2019-08-30)
Background: Restoration of the immune system has been observed in many cohorts worldwide upon initiation of antiretroviral therapy. However, we have reported partial restoration of the T cell subset function despite seven ...
EVALUATION OF AN IN-HOUSE PROBE-BASED REAL-TIME PCR TEST FOR EARLY INFANT HIV-1 DIAGNOSIS IN UGANDA
(2019)
Background: HIV infection remains a problem worldwide, with the majority of the cases being in resource-limited settings. Pediatric HIV testing is lagging with only 43 % of HIV-exposed infants being tested within the ...