Browsing School of Medicine (Sch. of Med.) Collections by Type
Now showing items 21-40 of 58
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High CD56++CD16- natural killer (NK) cells among suboptimal immune responders after four years of suppressive antiretroviral therapy in an African adult HIV treatment cohort
(BMC Immunology, 2014)Background: Up to 40% of HIV-infected individuals receiving Highly Active Antiretroviral Therapy (HAART) have poor CD4+ T-cell recovery. The role of natural killer (NK) cells in immune recovery during HAART is not well ... -
High prevalence of glaucoma among patients in an Onchocerciasis Endemic Area (Mahenge, Tanzania)
(MDPI, 2022)Onchocerciasis is known to cause skin lesions and blindness, but there is also epidemiological evidence that onchocerciasis is associated with epilepsy, including nodding syndrome. We carried out ocular exams in persons ... -
Impaired T-cell proliferation among HAARTtreated adults with suboptimal CD4 recovery in an African cohort
(BMC Immunology, 2013)Background: Most HIV-infected subjects exhibit a progressive rise in CD4 T-cell counts after initiation of highly active antiretroviral therapy (HAART). However, a subset of individuals exhibit very poor CD4 T-cell recovery ... -
Incidence of preeclampsia and retention to prenatal care in Northern Uganda.
(East African Medical Journal, 2022-08-23)Background: Known risk factors for preeclampsia include women of African descent and low socioeconomic status. This means all the mothers in Northern Uganda are at risk. In Uganda preeclampsia causes 12 – 19% of maternal ... -
Initiatives supporting evidence informed health system policymaking in Cameroon and Uganda: A comparative historical case study
(BioMed Central, 2014-11)Background: There is a scarcity of empirical data on institutions devoted to knowledge brokerage and their influence in Africa. Our objective was to describe two pioneering Knowledge Translation Platforms (KTPs) supporting ... -
Knowledge gaps, attitude and beliefs of the communities about sickle cell disease in Eastern and Western Uganda
(East African Medical Journal, 2009)Background: The management of sickle cell disease (SCD) has remained insurmountable in developing countries such as Uganda, because most communities are not aware of it. Objective: To determine knowledge gaps, attitudes ... -
Learning health professionalism at Makerere University: an exploratory study amongst undergraduate students
(BMC Medical Education, 2010)Background: Anecdotal evidence shows that unprofessional conduct is becoming a common occurrence amongst health workers in Uganda. The development of appropriate professional values, attitudes and behaviors is a continuum ... -
Longitudinal patients’ cohorts for impactful research and HIV care at the Infectious Diseases Institute
(2022)Introduction Observational studies provide important evidence supporting the feasibility and effectiveness of health interventions. The 20-year-old Infectious Diseases Institute (IDI) established to respond to infectious ... -
Low-level viraemia: An emerging concern among people living with HIV in Uganda and across sub-Saharan Africa
(AOSIS, 2022)Attaining viral load (VL) suppression for over 95% of the people living with HIV on antiretroviral therapy is a fundamental step in enabling Uganda and other sub-Saharan African countries to achieve global Sustainable ... -
Makerere University-Uganda Heart Institute collaborative cardiovascular disease training and research since 1988
(2022)Background Makerere University College of Health Sciences has been collaborating with the Uganda Heart Institute to build capacity for research, training and clinical care in cardiovascular medicine for the last 34 years ... -
Malaria diagnosed in an urban setting strongly associated with recent overnight travel: A case–control study from Kampala, Uganda
(2020)Malaria is frequently diagnosed in urban Kampala, despite low transmission intensity. To evaluate the association between recent travel out of Kampala and malaria, we conducted a matched case–control study. Cases were ... -
Malaria hospitalisation in East Africa: age, phenotype and transmission intensity
(BMC, 2022)Background: Understanding the age patterns of disease is necessary to target interventions to maximize cost-effective impact. New malaria chemoprevention and vaccine initiatives target young children attending routine ... -
“A man without money getting a sexual partner? It doesn’t exist in our community”: male partners’ perspectives on transactional sexual relationships in Uganda and Eswatini
(Informa UK Limited, 2021)Research on transactional sexual relationships has largely focused on women’s perspectives. Better understanding the men’s views—especially regarding relationships with adolescent girls and young women—can inform HIV ... -
Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: A prospective cohort study
(BMC, 2020)Background: Acute kidney injury (AKI) is increasingly recognized as a consequential clinical complication in children with severe malaria. However, approaches to estimate baseline creatinine (bSCr) are not standardized in ... -
Microbial characteristics of dental caries in HIV positive individuals
(2022)Background: Dental caries is a multifactorial disease that affects many people. Even though microorganisms play a crucial role in causing dental caries, diagnosis is routinely macroscopic. In order to improve early detection ... -
Mobile Phone-based intervention to promote un-interrupted HIV treatment during the COVID-19 pandemic
(2022)Introduction: Keeping HIV-infected adults away from the health care system during the COVID-19 travel restrictions, presents a challenge to HIV treatment adherence. Methods: This study focused on the initial two phases ... -
Mortality among children under five years admitted for routine care of severe acute malnutrition: a prospective cohort study from Kampala, Uganda
(BMC, 2020)Background: Mortality among children under 5 years of age admitted to malnutrition units in sub-Saharan Africa remains high. The burden of HIV infection, a major risk factor for mortality among patients with severe acute ... -
MOS HIP: McMaster outcome study of hypertension in pregnancy
(Elsevier, 2001-05-08)Background: The offspring of women with hypertension during pregnancy are at increased risk of low birth weight, preterm birth, diseases of prematurity and death. The risk of developing these outcomes among women with ... -
A need to accelerate health research productivity in an African University: the case of Makerere University College of Health Sciences.
(Health Research Policy and Systems, 2017)Background: In the last decade, Makerere University College of Health Sciences (MakCHS) has taken strides in research and training to improve healthcare through collaborative training and research programs. However, ... -
Neutrophil gelatinase-associated lipocalin is elevated in children with acute kidney injury and sickle cell anemia, and predicts mortality
(Elsevier, 2022)Urine neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury that has been adapted to a urine dipstick test. However, there is limited data on its use in low and-middle-income countries ...