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Now showing items 81-90 of 165
Exploring the global genetic diversity of P. falciparum Pf113 malaria vaccine candidate gene
(Makerere University, 2022)
The malaria disease burden is still of great concern especially in sub-Saharan Africa among children below the age of 5 years. Evolution of the P. falciparum parasite in response to intervention measures as well as the ...
Comparison of the performance of RNA extraction kits used in the diagnosis of COVID-19 against TRIZOL-the gold standard for RNA extraction
(Makerere University, 2022-12)
Background: During the COVID-19 pandemic, the Test-Trace-Isolate-Quarantine (TTIQ) strategy was used to break chains of transmission. Diagnosis is a key step in this strategy, and it is done using various RNA extraction ...
Development and validation of an HPLC-UV method for the simultaneous determination of Efavirenz and Dolutegravir in human plasma
(Makerere University, 2022-12)
Background: Although HIV/AIDS possess a challenge, global efforts have been mounted to address the epidemic. These include the massive role out of anti-retroviral therapy (ART) globally. To date either efavirenz or ...
Perspectives of patients with advanced cancer on information disclosure during the informed consent process for clinical care at the Uganda Cancer Institute
(Makerere University, 2022-01)
Informed consent is a widely accepted legal, ethical and regulatory requirement in medical care
and research, but its practice varies by context and the reality often differs from the theoretical
ideals. Disclosure of ...
Assessment of quality of raw bovine milk sold in Kampala City: A cross sectional study
(Makerere University, 2021-03)
Background: Recently there has been increasing reports concerning the safety of certain foods consumed in Uganda. Milk and meat sold on the Ugandan market have been reported to be contaminated with chemicals or adulterants ...
An evaluation of the microbiological quality of commonly marketed dietary supplements in retail pharmacies in Kampala City, Uganda
(Makerere University, 2023)
Background: Dietary supplements are products that contain concentrated sources of nutrients and whose purpose is to add nutritional value (supplement) to normal diet. One of the critical indicators of the safety of dietary ...
Pharmacokinetic/pharmacodynamic Modeling to optimize efavirenz dosing in HIV/AIDs infected children from Sub-Saharan Africa.
(Makerere University, 2022-12)
Aim:Using a model‐based approach, the efavirenz steady‐state pharmacokinetics in Sub-Saharan African children is characterized, quantifying demographic and genotypic effects on the drug's disposition. Simulations are also ...
Perceptions and experiences on identification and management of conflicts of interest during the ethical review process.
(Makerere University, 2022-04)
Background: The increasing growth of research involving humans in Uganda has been paralleled with the establishment of research ethics committees. These committees conduct ethical review of research protocols to ensure ...
Use of natural killer cell based assays to assess response to isoniazid preventive therapy among Type 2 Diabetes patients with latent tuberculosis
(Makerere University, 2022-12)
Background: Despite the presence of latent tuberculosis treatment such as Isoniazid treatment therapy, a quarter of the global population remains latently infected with the numbers expected to increase. There is also an ...
Early cytokine profiles associated with mild and asymptomatic COVID-19 disease severity in Uganda
(Makerere University, 2022-12-20)
Emergence of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) constituted a global health threat of highly impactful and pandemic proportions. However, low COVID-19 disease severity was observed in Uganda ...