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Host genetic variations and their association with malaria among Ugandan children
(Makerere University, 2021-04)
This thesis comprises studies of the relationship between host genetic factors and incidence of uncomplicated malaria in a vaccine trial site in Iganga district. The studies focused on selected host gene markers that are ...
The evaluation of effect of canarium schweinfurthii leaf and pulp extracts on blood glucose levels in oral glucose load - induced hyperglycemia, heamatological parameters and safety in wistar albino rats
(Makerere University, 2022-03-14)
Background: Canarium schweinfurthii (C. schweinfurthii) is a common medicinal plant in Uganda used as food and as medicine in the management of Diabetes mellitus type 2 and anemia by local communities and traditional ...
Vegf protein expression in gastric cancer and associated clinical pathological features as seen at the Department of Pathology, Makerere University
(Makerere University, 2022-03-17)
Background: Gastric cancer is the 5th most common cancer accounting for 5.7% of all cancers in the world and causes about 783,000 deaths annually. In Uganda the incidence of gastric cancer increased from 0.8 cases per ...
Attitudes and practices of herbalists towards the informed consent process
(Makerere University, 2022)
Introduction: Informed Consent (IC) is a major cornerstone in medical ethics that is expected to be implemented universally in healthcare. The growing use of herbal medicines in developing countries has aroused concerns, ...
Evaluation of contractile activity of the extracts of Gynandropsis gynandra Linn on isolated rabbit uterus and ileum
(Makerere University, 2022)
Diarrhea due to exaggerated GIT motility and maternal death due to delayed labor remain serious health challenges; and among the leading causes of mortality globally especially among children and pregnant mothers respectively. ...
Molecular epidemiology of antimicrobial resistance at a human-animal interface in pastoralist community of Kasese District, Uganda
(Makerere University, 2021-04)
Background: Intensive usage of antimicrobials in the management of animal diseases may cause selection for resistance among microorganisms. Transmission of resistant bacteria from the wild and domestic food animals to ...
Prevalence and histological types of kidney disease in autopsied persons at Kampala Capital City Authority Mortuary.
(Makerere University, 2022-02)
Introduction: It is estimated globally that in 2016, 5-10 million people died from kidney dis-ease (KD) and about 1.7 million died from acute kidney injury. In sub Saharan Africa the prevalence of KD is quite high and is ...
Participants’ understanding of informed consent for genomic research: a case of the CAfGEN study.
(Makerere University, 2020-07)
Introduction: For informed consent to be valid, prospective participants are required to have adequate understanding of research prior to making decisions about participation. Studies have reported that participants in ...
Simulation of clonal expansion and latent HIV reservoir size prediction using machine learning in virally suppressed individuals in Uganda
(Makerere University, 2022-07)
Background: HIV can survive as pro-viruses that do not undergo transcription mostly within resting memory CD4+ T cells despite prolonged antiretroviral therapy (ART). This Latent Viral Reservoir (LVR) has an extremely long ...
Unravelling the genetic risk associated with major depressive disorder among an ethnically diverse African ancestry population
(Makerere University, 2022-03)
Major depressive disorder (MDD), which is a significant contributor to the global health burden is characterised by a pervasive low mood and an inability to feel pleasure in normally pleasurable activities. Most MDD genetic ...