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Sputum microRNA profiles of treatment-naïve and patients on antituberculosis therapy in Mulago National Referral Hospital
(Makerere University, 2021-03-29)
Background: Worldwide, tuberculosis (TB) is the leading cause of death due to a single infectious
agent. This is attributed to the limitations of the current diagnostic tests in terms of sensitivity and
specificity. ...
Role of Killer-cell Immunoglobulin-like Receptors and Human Leukocyte Antigens in Transmission and Severity of Malaria in Uganda
(Makerere University, 2021-04-08)
Background
Malaria is a life-threatening disease caused by Plasmodium falciparum. In 2018, there were an estimated 228 million cases of malaria worldwide and 405,000 malaria deaths. Malaria burden is greatly affected by ...
Evaluation of quality of hepatitis B vaccines circulating on the Ugandan market
(Makerere University, 2021-04-28)
Vaccination is the greatest public health intervention in these modern times. Since the Ministry
of Health -Uganda rolled out the Hepatitis B vaccination program, there has been a continuous
decrease in the number of new ...
Human herpes virus 8 DNA in blood as a marker of Kaposi’s Sarcoma in HIV positive Ugandan patients.
(makerere university, 2020-01-28)
Introduction; Kaposi’s Sarcoma (KS) is an abnormal excessive growth of blood vessels associated with human herpes virus 8 (HHV-8), as the causative agent. In HIV infected individuals, HHV-8 is the major cause of AIDS-related ...
Prevalence of immune non-response to Hepatitis B virus vaccine among secondary school students in Kumi district, Eastern Uganda
(Makerere University, 2021-05-11)
Background: Hepatitis B virus is still a silent killer disease in Ugandan communities, particularly in high burdened regions. Despite Government initiative for mass vaccination program for those areas, there has been ...
BCL-2 protein expression in oral squamous cell carcinoma and associated clinicopathological features as seen at the Pathology Department, Makerere University
(Makerere University, 2021-11)
Background: Predicting clinical behavior of oral squamous cell carcinoma based on histopathological analysis requires immunohistochemical supplementation with biomarkers like Bcl-2 protein that can be used in prognostic ...
Characterisation of Resistance Associated Variants (RAVs) to the newly approved anti-tuberculosis drugs Delamanid, Pretomanid, Bedaquiline, Clofazimine and Linezolid in isolates from a 2016/2017 Tanzanian Anti-Tuberculosis Drug Resistance Survey
(Makerere University, 2022)
Background: Drug-resistant Tuberculosis (TB) undermines the effort to curb TB disease. It is associated with higher treatment costs, longer treatment periods and more adverse effects (Jeon, 2015). Recently, three new ...
Evaluation of hepatitis b surface antigen (hbsag) as a surrogate marker for hepatitis b viral load estimation.
(Makerere University, 2021-04-28)
Background: A Hepatitis B Virus (HBV) viral load measurement is recommended for
diagnosis and monitoring of patients on treatment for Chronic Hepatitis B (CHB). However,
these diagnostic techniques are molecular-based ...
Evaluation of stool with sputum DNA on FTA card, microscope slide and TB-Lamp for Mycobacterium Tuberculosis detection using Xpert MTB/Rif (Xpert) as Gold standard among Pulmonary Tuberculosis patients
(Makerere University, 2021-04-19)
The Xpert MTB/RIF (Xpert) and TB-Lamp assay technology allows rapid and sensitive diagnosis of pulmonary tuberculosis (PTB) from sputum specimens. The conventional plastic sputum containers allow transportation of sputum ...
Stakeholders perceptions and experiences regarding research at Makerere University College of Health Sciences
(Makerere University, 2021-02-17)
The study purposed to explore the perceptions and experiences of key research stakeholders at Makerere College of Health Sciences (MaKCHS) and affiliate research institutions. Several research studies conducted at the ...