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Now showing items 121-130 of 167
Occurrence of extended Spectrum Beta-Lactamase producing Enterobacteriaceae in wastewater and receiving water bodies.
(Makerere University, 2023)
Antimicrobial resistance is taking center-stage in increasing morbidity and mortality, especially in Low- and middle-income countries like Uganda. WHO drew a roadmap to increase antimicrobial resistance surveillance using ...
Identification of loci associated with environmental adaptation in indigenous cattle of Uganda
(Makerere University, 2023-11)
Cattle are invaluable to the people of Uganda. They are a source of pride of tribes and are also used in social functions. In Uganda, local breeds of cattle are kept due to their tolerance to locally prevailing animal pests ...
Genomic determinants of virulence and antimicrobial resistance in colistin resistant Klebsiella pneumoniae isolates from Mulago National Referral Hospital
(Makerere University, 2023-08-29)
Introduction: Multidrug resistance and high virulence in K. pneumoniae are of particular concern and have emerged as critically alarming threats to the global community. Worringly, K.pneumoniae has become resistant to ...
Evaluation of the ameliorative effects of the methanolic and total crude extracts of Persea americana seeds on biochemical and haematological parameters in wistar albino rats induced with type 2 diabetes mellitus.
(Makerere University, 2023-11)
Diabetes Mellitus is a chronic hyperglycaemic condition caused by low insulin production with 2 major types i.e., Type 1 and Type 2 DM (NIDDM). Type 2 DM accounts for 90% of DM cases and its global prevalence is expected ...
Evaluation of the Diagnostic Validity of the HIV VISITECT CD4 Point-of-Care Rapid Diagnostic Test Using PIMA Analyzer as the Gold Standard in Uganda.
(Makerere University, 2023-09-30)
Background: HIV remains prevalent in Uganda, and the cluster of differentiation-4 (CD4)
markers are widely used to support and monitor disease progression.
Objectives: This study aimed to compare the diagnostic validity ...
Mutations in MDR-TB Isolates from Bedaquiline-Resistance Conferring Mulago Hospital Kampala, Uganda
(Makerere University, 2023-11-20)
Introduction: In 2018, based on an evidence-based policy, the World Health Organization (WHO) updated its guidelines on the treatment of drug-resistant tuberculosis with recommendation of bedaquiline as a core drug in the ...
Evaluation of antidepressant effects and safety of Lavendula angustifolia aqueous and total crude leaf extracts in Wistar albino rats.
(Makerere University, 2023-07-28)
Introduction: Depression continues to be a major problem in Ugandan population and communities’ use medicinal plants like L. angustifolia (Lavandula angustifolia) for its treatment.Objective: To establish the antidepressant ...
In vitro efficacy of bacteriophages against Extended-spectrum β-Lactamase producing Escherichia coli Isolated from Patients with Urinary Tract Infections
(Makerere University, 2021-04)
Background: Escherichia coli, a gram-negative bacterial pathogen, which harbors extended spectrum β-lactamase enzymes (ESBLs) is the major cause of UTIs. The wide spread emergence and expansion of ESBL producing E. coli ...
L everaging on the Cross-Reactivity and recovery of leptospira serovars in stored cultures to mitigate limitations of the Microscopic Agglutination Test
(Makerere University, 2023-11-13)
Leptospirosis is one of the most widely spread bacterial zoonotic that is endemic in subtropical and tropical countries; accounting for a global annual incidence of 1.03 million human cases and 58,900 deaths. (Alinaitwe ...
Molecular epidemiology and antimicrobial resistance determinants of Neisseria gonorrhoeae among males with urethritis in Kampala, Uganda
(Makerere University, 2023-09-21)
Gonorrhoea is a highly prevalent bacterial sexually transmitted infection (STI) that negatively impacts sexual and reproductive health (SRH) and that is also greatly associated with serious clinical sequelae. Gonorrhoea ...