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Now showing items 111-120 of 167
Characterizing microbial diversity and resistome in urban sewage using shotgun metagenomics in Kampala, Uganda
(Makerere University, 2023-05)
Introduction: Recently, antimicrobial resistant (AMR) infections have shown up as the leading threat to human health, having 700,000 directly attributed estimated deaths per year worldwide. For Africa, AMR data is still ...
Bacille calmette-guérin, diphtheria-tetanus, and measles vaccine responses of infants born to mothers with active tuberculosis disease
(Makerere University, 2023-11-14)
Background: Babies born to mothers with active tuberculosis disease (ATB) are at risk of poor clinical outcomes such as low birth weight and perinatal mortality. However, little is known about the influence of maternal ...
Genomic study of Klebsiella pnuemoniae from neonatal invasive, neonatal and maternal carriage at Kawempe National Referral Hospital, Uganda
(Makerere University, 2023-11-14)
Neonatal infections particularly bloodstream infections (BSI) pose a significant health risk, necessitating a comprehensive understanding of the genetic characteristics of causative strains for effective treatment and ...
Bacterial-Derived Outer Membrane Vesicles in Chronic Obstructive Pulmonary Disease and HIV Infection in a Ugandan Population
(Makerere University, 2023-11-01)
Background: The prevalence of chronic obstructive pulmonary disease (COPD) has increased among people living with HIV (PLWH) despite the global scale-up of antiretroviral therapy (ART). Currently, it is not fully known ...
Diagnostic performance evaluation of lateral flow florescence immunoassay (LFIA)- based point-of-care platforms in the measurement of selected cancer makers; PSA, CEA and CA125
(Makerere University, 2023-11-14)
Background: In Uganda, cancer diagnosis has been largely dependent on conventional methods such as histopathology. These methods although very accurate they however require specialized facilities with trained personnel ...
Bacterial profile and antimicrobial susceptibility patterns of isolates from surgical site infections at Luwero hospital
(Makerere University, 2023-11-14)
Background: A surgical site infection (SSI) is an infection that develops within at most 30 days following a surgical procedure or after one year in case if an implant was placed. The American Centers for Disease Control ...
Immunological Biomarkers among patients with Severe COVID-19
(Makerere University, 2023-11)
Background: SARS-COV 2 is characterized by a heterogenous disease course in which some cases may be asymptomatic, mild, and severe which is life-threatening. Most hospitalized patients with COVID-19 have been found to have ...
African human variants that potentially impact the outcome of SARS-CoV-2 infection
(Makerere University, 2023-11-15)
Introduction: The SARS-CoV-2 pandemic has had an unprecedented global impact, resulting in millions of confirmed cases and deaths. However, the severity and death rates varied among different ethnicities and geographical ...
Effects of Helminth Infections on Type-2 Immune Responses in children with asthma
(Makerere University, 2023-11-14)
Background: Both asthma and helminths demonstrate a predominant type-2 immune response. Additionally, helminths have been demonstrated to have immuno-modulatory roles in allergic conditions such as asthma. Therefore, the ...
The HBV Serological patterns, Treatment eligibility, Genotypes and the TNF-α-863C/A & 1031 T/C Promoter gene polymorphisms in a high and low endemic region of Uganda.
(Makerere University, 2023-04-14)
ABSTRACT
Introduction: There is a disparity in HBV endemicity in Uganda. This can be influenced by the HBsAg seronegative persons who continue to shade the virus, chronically infected HBV not initiated on therapy, the ...