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Patient single nucleotide polymorphisms assiocated with Mycobacterium tuberculosis genotypes in Ugandan population
(Makerere University, 2022-12)
Uganda is one of the 30 World Health Organization-designated countries with a high burden of TB/HIV, with three main dominant genotypes that cause tuberculosis. Recent studies have shown that the M. tuberculosis Uganda ...
Mycobacterium tuberculosis expression of Antigen 85B (Ag85B) in different culture conditions
(Makerere University, 2022-03)
Background: : Secretion of specific proteins by Mycobacterium tuberculosis contributes to pathogenesis and immune responses in tuberculosis disease yet the quantification of these secreted proteins in-vitro are poorly ...
Correlation of plasma HIV-1 p24 antigen levels with viral load in samples of HIV positive patients on ART in Uganda
(Makerere University, 2022-12)
Globally, a total of 38.0 million people living with HIV, of which 1.7 million people became newly infected with HIV in 2019. Additionally, an average of 690,000 people died from AIDS-related illnesses in 2019, and 26 ...
Performance evaluation of computational programs to predict Human leucocyte antigen (HLA) genotypes on African whole exome sequence data
(Makerere University, 2023)
Introduction: Accurate Human Leucocyte Antigen (HLA) genotyping is critical in studies involving the immune system and transplantation medicine. HLA genes encode proteins that have a central role in immune responses that ...
Immunological and genetic risk factors associated with cognitive and neurological impairment in severe malaria in Ugandan children
(Makerere University, 2023)
Background. Endothelial activation is involved in pathophysiology of severe malaria leading to blood-brain-barrier dysfunction (BBB), which could occur in the absence of neurologic signs, or may be associated with long-term ...
Inflammaging and anti-inflammaging cytokines in the HIV-seropositive geriatric population in Uganda
(Makerere University, 2023)
Background: Although the life expectancy of people living with HIV (PLWH) has increased significantly, HIV infection seems to be associated with accelerated ageing processes compared to uninfected individuals. Longevity ...
Prevalence of protective levels of anti-HBs antibodies among 15-17 year old adolescents at kawempe division,Kampala,Uganda
(Makerere University, 2023-11-04)
BACKGROUND: Viral hepatitis is a global pandemic and HBV is one of the leading causes of liver-related cancer and cirrhosis. The inclusion of the HBV vaccine in National Immunization programs has contributed to the reduction ...
Characterisation of Candida africana among pregnant women with vaginitis
(Makerere University, 2023-11)
Candida africana, an emerging variant within the Candida albicans complex, has a global intra-albicans complex prevalence of 1.67% and varies between 0% and 8.4% depending on the region. It mainly causes vulvovaginal ...
Moral distress and coping strategies among nurses and midwives at Kawempe National Referral Hospital Kampala District
(Makerere University, 2023-07-28)
Background: Moral distress is a major issue in nursing practice, especially for those in clinical care. The existence of such distress may affect nurses’ physical and mental health, as well as their quality of life and ...
Binding characteristics of selected commercial antibodies against recombinant HIV Subtype D P24 antigens
(Makerere University, 2023-01)
The standard method for monitoring HIV treatment response is quantitative RT-PCR, but it is difficult to implement in low and middle income countries due to infrastructure and personnel requirements. Point of care technologies ...