Browsing School of Bio-Medical Sciences (Bio-Medical) Collections by Author "Ogwal-Okeng, Jasper"

Now showing items 1-7 of 7

    • Factors predicting home storage of medicines in Northern Uganda 

      Ocan, Moses; Bbosa, Godfrey S.; Waako, Paul; Ogwal-Okeng, Jasper; Obua, Celestino (BioMed Central, 2014)
      Abstract Background Medicines are kept in households Worldwide for first aid, treatment of chronic or acute disease conditions. This promotes inappropriate use of medicines and hence the associated risks. The study ...

    • Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans 

      Mukonzo, Jackson K; Waako, Paul; Ogwal-Okeng, Jasper; Gustafsson, Lars L.; Aklillu, Eleni (Lippincott Wilkins & Williams, 2010)
      Abstract: Quinine is one of the most effective antimalarial drugs, although its clinical use is limited as a result of its narrow safety margin. Quinine is a substrate of the polymorphic p-glycoprotein and CYP3A4/3A5. This ...

    • HIV/AIDS patients display lower relative bioavailability of Efavirenz than healthy subjects 

      Mukonzo, Jackson K; Nanzigu, Sara; Rekic, Dinko; Waako, Paul; Roshammar, Daniel; Ashton, Michael; Ogwal-Okeng, Jasper; Gustafsson, Lars L.; Aklillu, Eleni (Adis Data Information BV., 2011)
      Background: Pharmacokinetic studies of antiretroviral drugs are often conducted in adult healthy subjects, and the results are extrapolated to HIV/AIDS patients. HIV/AIDS, however, is known to cause morphological and ...

    • A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans 

      Mukonzo, Jackson K; Röshammar, Daniel; Waako, Paul; Andersson, Maria; Fukasawa, Takashi; Milani, Lili; Svensson, Jan Olof; Ogwal-Okeng, Jasper; Gustafsson, Lars L.; Aklillu, Eleni (The British Pharmacological Society, 2009)
      AIMS Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, ...

    • A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans 

      Mukonzo, Jackson; Röshammar, Daniel; Waako, Paul; Andersson, Maria; Fukasawa, Takashi; Milani, Lili; Svensson, Jan Olof; Ogwal-Okeng, Jasper; Gustafsson, Lars L.; Aklillu, Eleni (Wiley-Blackwell, 2009)
      AIMS Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, ...

    • Patterns and predictors of self-medication in Northern Uganda 

      Ocan, Moses; Bwanga, Freddie; Bbosa, Godfrey S.; Bagenda, Danstan; Waako, Paul; Ogwal-Okeng, Jasper; Obua, Celestino (PLOS One, 2014)
      Self-medication with antimicrobial agents is a common form of self-care among patients globally with the prevalence and nature differing from country to country. Here we assessed the prevalence and predictors of antimicrobial ...

    • Substandard rifampicin based anti-tuberculosis drugs common in Ugandan drug market 

      Ocan, Moses; Vudriko, Patrick; Ntale, Muhammad; Ogwal-Okeng, Jasper; Obua, Celestino (Journal Of Pharmacy And Pharmacological Research, 2013)
      Background: Tuberculosis (TB) is an important curable infectious disease in Uganda; its treatment however is facing a challenge of increasing drug resistance. Although Rifampicin containing Fixed-Dose Combination (R-FDC) ...