Community-acquired pneumonia in Ugandan adults: short-term parenteral ampicillin therapy for bacterial pneumonia

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dc.contributor.author Yoshimine, Hiroyuki
dc.contributor.author Oishi, Kazunori
dc.contributor.author Mubiru, Francis
dc.contributor.author Takahashi, Hidehiko
dc.contributor.author Amano, Hideaki
dc.contributor.author Ombasi, Philip
dc.contributor.author Watanabe, Kiwao
dc.contributor.author Joloba, Moses
dc.contributor.author Aisu, Thomas
dc.contributor.author Ahmed, Kamruddin
dc.contributor.author Shimada, Masaaki
dc.contributor.author Mugerwa, Roy
dc.contributor.author Nagatake, Tsuyoshi
dc.date.accessioned 2013-07-05T06:10:12Z
dc.date.available 2013-07-05T06:10:12Z
dc.date.issued 2001
dc.identifier.citation American Journal of Tropical Medicine and Hygiene, 2001, 64(3, 4), pp. 172–177 en_US
dc.identifier.issn 0002-9637
dc.identifier.uri http://hdl.handle.net/123456789/984
dc.identifier.uri http://www.ajtmh.org/
dc.identifier.uri http://hdl.handle.net/10570/1588
dc.description The original publication is available from http://www.ajtmh.org/ en_US
dc.description.abstract A hospital-based prospective study of 99 patients with community-acquired pneumonia (CAP) was carried out in Kampala, Uganda. We evaluated microbiological etiologies, clinical features and effectiveness of short term parenteral ampicillin followed by oral amoxicillin for these patients in relation to HIV-status. We demonstrated a very high prevalence (75%) of HIV-1 infection. No significant difference was observed with respect to age, gender, prior antibiotic usage, symptoms, laboratory data or bacterial etiology between HIV-1-infected and HIV-uninfected CAP patients. Most strains of Streptococcus pneumoniae (n = 19) and Haemophilus influenzae (n = 8) isolated from HIV-1-infected patients were penicillin-resistant (95%) and β-lactamase producing (75%) strains, respectively. A high percentage of good clinical response was found in both HIV-1-infected (81%) and HIV-uninfected (86%) among 39 patients with CAP due to a defined bacterial pathogen. These data support the use of short-term parenteral ampicillin for patients with bacterial CAP irrespective of HIV-status. en_US
dc.language.iso en en_US
dc.publisher The American Society of Tropical Medicine and Hygiene en_US
dc.subject Pneumonia en_US
dc.subject Community-Acquired Pneumonia (CAP) en_US
dc.subject HIV en_US
dc.title Community-acquired pneumonia in Ugandan adults: short-term parenteral ampicillin therapy for bacterial pneumonia en_US
dc.type Journal article, peer reviewed en_US

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