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dc.contributor.authorHenry, Zamarano
dc.contributor.authorBenson, Musinguzi
dc.contributor.authorImmaculate, Kabajulizi
dc.contributor.authorGodfrey, Manirakiza
dc.contributor.authorWalker, Guti
dc.contributor.authorIvan, Muhwezi
dc.contributor.authorAyan, A. Hussein
dc.contributor.authorAgnes, Baweera
dc.contributor.authorBoaz, Kabahinda
dc.contributor.authorHerbert, Itabangi
dc.contributor.authorJoel, Bazira
dc.contributor.authorTaseera, Kabanda
dc.date.accessioned2024-06-24T06:17:38Z
dc.date.available2024-06-24T06:17:38Z
dc.date.issued2021
dc.identifier.citationZamarano H, Musinguzi B, Kabajulizi I, Manirakiza G, Guti W, Muhwezi I, Hussein AA, Baweera A, Kabahinda B, Itabangi H, Bazira J. Bacteriological profile, antibiotic susceptibility and factors associated with neonatal Septicaemia at Kilembe mines hospital, Kasese District Western Uganda. BMC microbiology. 2021 Dec;21:1-1.en_US
dc.identifier.issnhttps://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-021-02367-z
dc.identifier.urihttp://hdl.handle.net/10570/13290
dc.description.abstractIntroduction: Neonatal septicaemia is one of the most common leading causes of neonatal morbidity and mortality in developing countries. It is estimated to afect more than 30 million people worldwide annually, potentially leading to 6 million deaths. Objective(s): To determine the prevalence, bacteriological profle, antibiotic susceptibility and factors associated with neonatal septicaemia among neonates suspected to sepsis at Kilembe mines hospital. Methods: We conducted a descriptive cross-sectional study, where purposive sampling technique was used and blood was drawn from 122 neonates suspected to sepsis attending Kilembe Mines Hospital during the period (July to November 2020). Specimens were inoculated in Brain heart infusion broth, transported to Fortportal Regional Referral Hospital, plated daily up to 7days on blood, chocolate, MacConkey agar and incubated in aerobic and 5% carbondioxide. Pure colonies were identifed by Gram stain, biochemical tests and antibiotic sensitivities obtained by Kirby Bauer disc difusion method. Associations were tested using Chi square with Fisher’s exact or Yates correction tests where necessary and statistical signifcance was set at P<0.05. Stata (version 14) used for statistical analysis. Results: Blood cultures were positive in 59.0% cases with 55.5% male and 44.4% female. EOS was present in 56.9% and LOS 43.1% of the cases. Gram negative (56.9%) organisms were most implicated with neonatal septicaemia than Gram positives ones (43.1%). Gram positive organisms exhibited better susceptibility to amikacin, linezolid and vancomycin but more resistant to ampicillin and gentamicin. Of the aminoglycosides, amikacin exhibited a verge over netilmicin and gentamicin against Gram negative isolates. Risk factors of neonatal septicaemia were mother’s age of ≥25 years, employed mothers, tertiary-level of education, SVD, ANC attendance of ≥4 times, UTI during pregnancy, PROMS, foul Smelling liquor, urban residence, neonatal birth weight of ≥2500g, Apgar score 1st and 5th min ≥6 and resuscitation. Conclusion: Multi-drug resistant organisms were isolated. Therefore caution is required in selection of antibiotic therapy and avoid empirical treatment.en_US
dc.language.isoen_USen_US
dc.publisherBMCen_US
dc.relation.ispartofseries;1-11
dc.subjectNeonatal, Septicaemia, Bacteriological, Antibioticen_US
dc.titleBacteriological profle, antibiotic susceptibility and factors associated with neonatal Septicaemia at Kilembe mines hospital, Kasese District Western Ugandaen_US
dc.typeArticleen_US


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