dc.contributor.author | Batte, Anthony | |
dc.contributor.author | Starr, Michelle C. | |
dc.contributor.author | Schwaderer, Andrew L. | |
dc.contributor.author | Opoka, Robert O. | |
dc.contributor.author | Namazzi, Ruth | |
dc.contributor.author | Nishiguchi, Erika S. Phelps | |
dc.contributor.author | Ssenkusu, John M. | |
dc.contributor.author | John, Chandy C. | |
dc.contributor.author | Conroy, Andrea L. | |
dc.date.accessioned | 2022-11-18T08:01:03Z | |
dc.date.available | 2022-11-18T08:01:03Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Batte et al (2020). Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: A prospective cohort study. BMC Nephrology (2020) 21:417 | en_US |
dc.identifier.issn | 1471-2369 | |
dc.identifier.uri | https://doi.org/10.1186/s12882-020-02076-1 | |
dc.identifier.uri | http://hdl.handle.net/10570/10973 | |
dc.description.abstract | Background: Acute kidney injury (AKI) is increasingly recognized as a consequential clinical complication in children with severe malaria. However, approaches to estimate baseline creatinine (bSCr) are not standardized in this unique patient population. Prior to wide-spread utilization, bSCr estimation methods need to be evaluated in many populations, particularly in children from low-income countries.
Methods: We evaluated six methods to estimate bSCr in Ugandan children aged 6 months to 12 years of age in two cohorts of children with severe malaria (n = 1078) and healthy community children (n = 289). Using isotope dilution mass spectrometry (IDMS)-traceable creatinine measures from community children, we evaluated the bias, accuracy and precision of estimating bSCr using height-dependent and height-independent estimated glomerular filtration (eGFR) equations to back-calculate bSCr or estimating bSCr directly using published or population-specific norms.
Methods: We evaluated six methods to estimate bSCr in Ugandan children aged 6 months to 12 years of age in two cohorts of children with severe malaria (n = 1078) and healthy community children (n = 289). Using isotope dilution mass spectrometry (IDMS)-traceable creatinine measures from community children, we evaluated the bias, accuracy and precision of estimating bSCr using height-dependent and height-independent estimated glomerular filtration (eGFR) equations to back-calculate bSCr or estimating bSCr directly using published or population-specific norms.
Conclusions: We recommend using height-independent age-based approaches to estimate bSCr in hospitalized children in sub-Saharan Africa due to challenges in accurate height measurements and undernutrition which may impact bSCr estimates. In this population the Pottel-age based GFR estimating equation obtained comparable bSCr estimates to population-based estimates in healthy children. | en_US |
dc.description.sponsorship | National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke,
Fogarty International Center,
Ralph W. and Grace M. Showalter Research Award | en_US |
dc.language.iso | en | en_US |
dc.publisher | BMC | en_US |
dc.subject | Acute kidney injury | en_US |
dc.subject | Baseline creatinine | en_US |
dc.subject | Schwartz | en_US |
dc.subject | Pottel | en_US |
dc.subject | Severe malaria | en_US |
dc.subject | Sub-Saharan Africa | en_US |
dc.subject | Mortality | en_US |
dc.subject | Undernutrition | en_US |
dc.subject | Paediatric | en_US |
dc.title | Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: A prospective cohort study | en_US |
dc.type | Article | en_US |