Development of a herbal suspension containing methanolic leaf extracts of Aspilia Africana for management of Peptic Ulcer disease

Abstract

Peptic Ulcer disease still remains a significant cause of morbidity and mortality worldwide with a significant burden in low- and middle-income countries. Several studies to evaluate the antiulcer effect of Aspilia Africana have been conducted and the extract found to be effective against the disease. This prompted the formulation and evaluation of the herbal suspension containing the extract which was assessed for activity against peptic ulcer disease in different groups of mice. Peptic Ulcer Disease was induced into the mice by administration of 70% ethanol and this was followed by validation of the Aspilia Africana extract (N0) for antiulcer activity and later the different formulations containing the extract (N1, N2, N3) were assessed for the same by administering 1000mg/kg of extract in each formulation for a period of 14 days. The results of the above formulations were compared of those of the positive control (N4) that received omeprazole. The rats at the end of the administration were sacrificed on day 15 and their stomachs were dissected out and histologically examined. Results from histology all revealed that all the formulations had antiulcer activity in all the groups treated, though with varying degrees and the formulation with the best results was taken as the lead. There were no worrying side effects and all results from acute toxicity studies were all tolerable.