| dc.contributor.author | Nsobya, Samuel L. | |
| dc.contributor.author | Dokomajilar, Christian | |
| dc.contributor.author | Greenhouse, Bryan | |
| dc.contributor.author | Rosenthal, Philip J. | |
| dc.contributor.author | Dorsey, Grant | |
| dc.date.accessioned | 2012-10-15T20:21:02Z | |
| dc.date.available | 2012-10-15T20:21:02Z | |
| dc.date.issued | 2006-03-08 | |
| dc.identifier.citation | Nsobya, S.L., Dokomajilar, C., Greenhouse, B., Rosenthal, P.J., Dorsey, G. (2006). Selection of plasmodium falciparum pfmdr1 Alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic. Antimicrobial Agents and Chemotherapy -Journal-, 50(5) | en_US |
| dc.identifier.issn | 0066-4804 | |
| dc.identifier.uri | http://hdl.handle.net/10570/847 | |
| dc.description | Article | en_US |
| dc.description.abstract | Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N,184F, and 1246D significantly increased in prevalence after treatment. All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug | en_US |
| dc.description.sponsorship | National Institutes of Health/Fogarty International Center (K01 TW00007), the Centers for Disease Control and Prevention/Association of Schools of Public Health cooperative agreement “Malaria Surveillance and Control in Uganda” (SA3569 and S1932-21/21), and the Doris Duke Charitable Foundation. en
format.extent 56430 bytes | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | American Society for Microbiology | en_US |
| dc.subject | Polymorphisms | en_US |
| dc.subject | Pretreatment | en_US |
| dc.subject | Artemether-lumefantrine | en_US |
| dc.subject | Plasmodium falciparum | en_US |
| dc.subject | Malaria | en_US |
| dc.subject | Antimalarial therapy | en_US |
| dc.subject | Uganda | en_US |
| dc.title | Selection of plasmodium falciparum pfmdr1 Alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic | en_US |
| dc.type | Journal article, peer reviewed | en_US |
