School of Bio-Medical Sciences (Bio-Medical): Recent submissions
Now showing items 401-420 of 423
-
Comparison of methods in the recovery of nucleic acids from archival formalin-fixed paraffin-embedded autopsy tissues
(Elsevier, 2010)Archival formalin-fixed paraffin-embedded (FFPE) human tissue collections are typically in poor states of storage across the developing world. With advances in biomolecular techniques, these extraordinary and virtually ... -
A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans
(The British Pharmacological Society, 2009)AIMS Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, ... -
HIV serostatus disclosure and lived experiences of adolescents at the Transition Clinic of the Infectious Diseases Clinic in Kampala, Uganda: a qualitative study
(Routledge, 2011)Most studies on HIV serostatus disclosure and adolescents focus on whether, how and when to disclose to adolescents their HIV diagnosis. Fewer studies have examined HIV serostatus disclosure by adolescents who know they ... -
HIV/AIDS patients display lower relative bioavailability of Efavirenz than healthy subjects
(Adis Data Information BV., 2011)Background: Pharmacokinetic studies of antiretroviral drugs are often conducted in adult healthy subjects, and the results are extrapolated to HIV/AIDS patients. HIV/AIDS, however, is known to cause morphological and ... -
Programmed cell death in neurodegenerative brain disease
(2008)Death of brain cells by either apoptosis or necrosis is the hall mark of the pathology of most brain infections such as Alzheimer’s disease and AIDS dementia. The death of astrocytes in association with brain tumours appears ... -
Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans
(Lippincott Wilkins & Williams, 2010)Abstract: Quinine is one of the most effective antimalarial drugs, although its clinical use is limited as a result of its narrow safety margin. Quinine is a substrate of the polymorphic p-glycoprotein and CYP3A4/3A5. This ... -
In silico prediction of efavirenz and rifampicin drug–drug interaction considering weight and CYP2B6 phenotype
(The British Pharmacological Society, 2010)AIMS This study aimed to test whether a pharmacokinetic simulation model could extrapolate nonclinical drug data to predict human efavirenz exposure after single and continuous dosing as well as the effects of concomitant ... -
Anatomical variations in the course of the sciatic nerve among ugandans.
(2008-05)BACKGROUND: The sciatic nerve is the biggest nerve in the body and supplies most of the lower limb except the anterior compartment of the thigh and the skin of the medical aspect of the leg. It is commonly injured during ... -
Nasopharyngeal carriage rate of Streptococcus pneumoniae in Ugandan children with sickle cell disease
(BioMed Central, 2012)Background: Nasopharyngeal carriage of Streptococcus pneumoniae is a determinant for invasive pneumococcal disease, which often complicates homozygous sickle cell disease. Here, we determined the nasopharyngeal carriage ... -
Inpatient mortality in children with clinically diagnosed malaria as compared with microscopically confirmed malaria
(Lippincott Wilkins & Williams, 2008)Background: Inpatient treatment for malaria without microscopic confirmation of the diagnosis occurs commonly in sub-Saharan Africa. Differences in mortality in children who are tested by microscopy for Plasmodium falciparum ... -
Zinc adjunct therapy reduces case fatality in severe childhood pneumonia: a randomized double blind placebo-controlled trial
(BioMed Central, 2012)Background: Pneumonia is a leading cause of children’s deaths in developing countries and hinders achievement of the fourth Millennium Development Goal. This goal aims to reduce the under-five mortality rate, by two thirds, ... -
Antimalarial susceptibility of plasmodium falciparum isolates from patients presenting with uncomplicated malaria at mulago hospital.
(2007-10)INTRODUCTION AND OBJECTIVES: Malaria remains the greatest cause of morbidity and mortality in sub-saharan Africa. This work was done to determine the sensitivity of plasmodium falciparum isolates to the currently used ... -
Assessment of nutritional status of adult liver disease patients in mulago hospital.
(2009-06)Introduction: The assessment of nutritional status is an internationally recognised practice that can help in easily identifying the patient’s nutritional needs. Malnutrition is common in patients with liver disease. The ... -
Prevalence of methicillin resistant staphylococcus aureus among isolates from surgical site infections in mulago hospital, kampala, uganda.
(2007-06)BACKGROUND: Methicillin resistant staphylococcus aureus (MRSA) is a worldwide health problem. MRSA isolates are resistant to penicillins and all other B-lactam antibiotics. Nosocomial MRSA are also resistant to a variety ... -
Autopsy study on maternal deaths in Mulago hospital
(2007-06)OBJECTIVES: To describe the anatomical pathological causes of maternal deaths, and establish their relationship with age and parity, in Mulago hospital. METHOD: The first 100 mothers, who died during pregnancy or within ... -
Malignant transformation in intra oral papillary lesions diagnosed in the department of pathology, faculty of medicine, Makerere University, Kampala
(2007-07)Oral papillary lesions account for two and a half percent of benign neoplastic lesions of the oral mucosa and occur at any site within the oral mucosa. Some oral papillary lesions have been associated with HPV infection. ... -
Assessment of renal function in destabilised diabetes mellitus patients admitted for short term treatment in Mulago hospital
(2009-01)Clinical testing to assess progression among persons with type 1 and type 2 diabetes mellitus is widely recommended to clinicians to improve patient’s clinical outcomes. An important recommendation is screening for diabetic ... -
An up-date on the prevalence of sickle cell trait in Eastern and Western Uganda.
(BioMed Central, 2010)Background: The first survey on sickle cell disease (SCD) done in Uganda in 1949, reported the district of Bundibugyo in Western Uganda to have the highest sickle cell trait (SCT) prevalence (45%). This is believed to be ... -
Emergence of sickle cell gene through migration and intermarriage: A case study
(Africa Journal of Animal and Biomedical Sciences, 2009)Sickle cell disease (SCD) is an inheritable disorder which is very common among persons of equatorial regions including Africa. The evolution of SCD is linked to malaria endemicity in which sickle cell traits are selected for ... -
Female genital tuberculosis in Uganda
(African Journal of Animal and Biomedical Sciences., 2008)A retrospective clinico-pathological study of 39 cases of female genital tuberculosis (FGTB) observed from 1976 – 1986 was conducted in the Department of Pathology, Medical School, Makerere University. The frequency of ...