School of Bio-Medical Sciences (Bio-Medical): Recent submissions
Now showing items 141-160 of 423
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Effect of hydrocortisone hormone on in-vitro reactivation of HIV-1 reservoirs
(Makerere University, 2022-07)The persistence of the HIV-1 reservoir in infected individuals represents a major hurdle to the development of a cure and complete eradication of HIV-1 infection. Stress hormones have also been shown to modulate immune ... -
Development of an in- house IgM and IgG ELISA for detection of exposure to SARS-COV2
(Makerere University, 2022-12)Background: Coronavirus disease of 2019 (COVID-19), proved a fatal respiratory disease and affected millions globally. Due to the faster transmission nature of the virus and any other predicted forms of viral mutations, ... -
Correlation of plasma HIV-1 p24 antigen levels with viral load in samples of HIV positive patients on ART in Uganda
(Makerere University, 2022-12)Globally, a total of 38.0 million people living with HIV, of which 1.7 million people became newly infected with HIV in 2019. Additionally, an average of 690,000 people died from AIDS-related illnesses in 2019, and 26 ... -
Evaluation of pre-existing cross reactive cellular immune responses to SARS-CoV-2 in Uganda
(Makerere University, 2022-12)Background: A low severity of COVID-19 disease has been reported in the Africa population more so in Uganda as compared to other regions like Europe, America and West Pacific. Over 169,996 people have been infected with ... -
Insights into genomic variations between Mycobacterium tuberculosis compartmentalized in the lungs and blood of HIV-infected individuals in Uganda
(Makerere University, 2022-08-19)Introduction: Mycobacterium tuberculosis (MTB), particularly clinical strains present a genomic diversity that ranges from several single nucleotide polymorphisms (SNPs) to insertions and deletions (INDELS). This study ... -
Morphometric variations of the pterion among skulls at the Galloway Osteological Collection in the Department of Human Anatomy Makerere University
(Makerere University, 2022-12-15)Background: The pterion is an important anatomical land mark in neuro surgery, it’s also important in Forensic examination of the human skull, to anatomists when teaching undergraduate medical students and postgraduates ... -
Evaluation of safety profiles and effect on glucose tolerance of different parts of Rhus vulgaris meikle, a medicinal plant used in the traditional management of Type II Diabetes Mellitus in Uganda
(Makerere University, 2022-12-15)Background: Indigenous management of diabetes mellitus is common but not fully explored. Objective: The study determined and compared the hypoglycemic activities of root bark and leaf extracts of R. vulgaris in high glucose ... -
Mycobacterium tuberculosis expression of Antigen 85B (Ag85B) in different culture conditions
(Makerere University, 2022-03)Background: : Secretion of specific proteins by Mycobacterium tuberculosis contributes to pathogenesis and immune responses in tuberculosis disease yet the quantification of these secreted proteins in-vitro are poorly ... -
Early cytokine profiles associated with mild and asymptomatic COVID-19 disease severity in Uganda
(Makerere University, 2022-12-20)Emergence of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) constituted a global health threat of highly impactful and pandemic proportions. However, low COVID-19 disease severity was observed in Uganda ... -
Metagenomic analysis of coronaviruses in bat fecal matter collected from a human-bat interface around Arua City, West Nile Region, Uganda
(Makerere University, 2022-10)Background Many recent disease outbreaks in humans had a zoonotic virus etiology. The ongoing coronavirus disease 2019 (COVID-19) pandemic has had devastating health and socioeconomic impacts. Bats are reservoirs for a ... -
Utility of urine LAM Biomarker for treatment response monitoring during 8 weeks of MDR-TB treatment at Mulago National Referral Hospital
(Makerere University, 2022-03)Background: The current methods used in monitoring treatment response among MDR - TB patients have low sensitivity, take long to give results, are expensive and require BSL3 facilities. It is known that MTB LAM as a biomarker ... -
Use of natural killer cell based assays to assess response to isoniazid preventive therapy among Type 2 Diabetes patients with latent tuberculosis
(Makerere University, 2022-12)Background: Despite the presence of latent tuberculosis treatment such as Isoniazid treatment therapy, a quarter of the global population remains latently infected with the numbers expected to increase. There is also an ... -
Genetic Diversity of Bundibugyo ebolavirus from Uganda and the Democratic Republic of Congo
(Makerere University, 2022-01-02)Background The Ebola virus is one of the deadliest known viral pathogens. It was first discovered in 1976 during two consecutive outbreaks in the Democratic Republic of Congo (DRC) and Sudan. Since then six known strains ... -
Effect of baseline immune status on the antibody responses to Hepatitis B vaccination among adults
(Makerere University, 2022-11-30)Background; Hepatitis B virus (HBV) causes vaccine-preventable Hepatitis B disease. However, the immune response to the Hepatitis B vaccine varies, and 5 – 15% of vaccine recipients do not produce sufficient antibodies. ... -
Metabolic syndrome among HIV positive patients on antiretroviral therapy attending the art clinic at Fortportal Regional Referral Hospital
(2022-10-18)ABSTRACT Introduction The continuing evolution of potent antiretroviral therapy (ART) has resulted in dramatic reductions in HIV-associated morbidity and mortality. However, the availability of newer ART regimes has ... -
Predicting major depressive disorder among adults Living with HIV In Uganda: An Artificial Intelligence Approach
(Makerere University, 2022-08-01)Background Major depressive disorder is a leading cause of disability worldwide and a major contributor to the overall global burden of disease. The biggest percentage of the MDD burden pertains to low- and middle-income ... -
Using Gene and miRNA expression profiles in Breast cancer risk prediction : a machine learning-based approach
(Makerere University, 2022)Breast cancer (BC) incidence is commonly accompanied by poor treatment outcomes due to late diagnosis. BC risk prediction is important for timely diagnosis but it’s clinical utility is limited by high risk bias. Genetic ... -
T cell Expression of CD153 in Latent Tuberculosis Infection and Type 2 Diabetes Mellitus
(Makerere University, 2022-06-22)The increasing prevalence of latent tuberculosis among individuals with type 2 diabetes mellitus has increased the public health importance of TB and non-communicable diseases, yet the immune correlates of protection or ... -
Insights into genomic variations between Mycobacterium tuberculosis compartmentalized in the lungs and blood of HIV-infected individuals in Uganda
(Makerere University, 2022)Introduction: Mycobacterium tuberculosis (MTB), particularly clinical strains present a genomic diversity that ranges from several single nucleotide polymorphisms (SNPs) to insertions and deletions (INDELS). This study ... -
Effect of aqueous extracts of Moringa oleifera leaves on serum C-peptide levels in alloxan mono-hydrate induced diabetic wistar albino rats
(Makerere University, 2022-01-28)ABSTRACT Background: Moringa oleifera is rich in phytochemicals, and in Uganda, its leaves, roots and seeds are widely consumed for self-medication by patients affected by diabetes mellitus, hypertension, HIV/AIDS and ...