School of Bio-Medical Sciences (Bio-Medical): Recent submissions
Now showing items 101-120 of 423
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Genomic determinants of virulence and antimicrobial resistance in colistin resistant Klebsiella pneumoniae isolates from Mulago National Referral Hospital
(Makerere University, 2023-08-29)Introduction: Multidrug resistance and high virulence in K. pneumoniae are of particular concern and have emerged as critically alarming threats to the global community. Worringly, K.pneumoniae has become resistant to ... -
Evaluation of the ameliorative effects of the methanolic and total crude extracts of Persea americana seeds on biochemical and haematological parameters in wistar albino rats induced with type 2 diabetes mellitus.
(Makerere University, 2023-11)Diabetes Mellitus is a chronic hyperglycaemic condition caused by low insulin production with 2 major types i.e., Type 1 and Type 2 DM (NIDDM). Type 2 DM accounts for 90% of DM cases and its global prevalence is expected ... -
Identification of loci associated with environmental adaptation in indigenous cattle of Uganda
(Makerere University, 2023-11)Cattle are invaluable to the people of Uganda. They are a source of pride of tribes and are also used in social functions. In Uganda, local breeds of cattle are kept due to their tolerance to locally prevailing animal pests ... -
Occurrence of extended Spectrum Beta-Lactamase producing Enterobacteriaceae in wastewater and receiving water bodies.
(Makerere University, 2023)Antimicrobial resistance is taking center-stage in increasing morbidity and mortality, especially in Low- and middle-income countries like Uganda. WHO drew a roadmap to increase antimicrobial resistance surveillance using ... -
The HBV Serological patterns, Treatment eligibility, Genotypes and the TNF-α-863C/A & 1031 T/C Promoter gene polymorphisms in a high and low endemic region of Uganda.
(Makerere University, 2023-04-14)ABSTRACT Introduction: There is a disparity in HBV endemicity in Uganda. This can be influenced by the HBsAg seronegative persons who continue to shade the virus, chronically infected HBV not initiated on therapy, the ... -
Effects of Helminth Infections on Type-2 Immune Responses in children with asthma
(Makerere University, 2023-11-14)Background: Both asthma and helminths demonstrate a predominant type-2 immune response. Additionally, helminths have been demonstrated to have immuno-modulatory roles in allergic conditions such as asthma. Therefore, the ... -
African human variants that potentially impact the outcome of SARS-CoV-2 infection
(Makerere University, 2023-11-15)Introduction: The SARS-CoV-2 pandemic has had an unprecedented global impact, resulting in millions of confirmed cases and deaths. However, the severity and death rates varied among different ethnicities and geographical ... -
Diagnostic accuracy of mycobacterium tuberculosis DNA as detected by the top assay among the individuals with paucibillary TB
(Makerere University, 2023-11)Background: One of the major reasons leading to the increased incidence of TB is the lack of a diagnostic with high sensitivity that can be relied on to capture even patients with low burden TB. This had been attempted by ... -
Immunological Biomarkers among patients with Severe COVID-19
(Makerere University, 2023-11)Background: SARS-COV 2 is characterized by a heterogenous disease course in which some cases may be asymptomatic, mild, and severe which is life-threatening. Most hospitalized patients with COVID-19 have been found to have ... -
Bacterial profile and antimicrobial susceptibility patterns of isolates from surgical site infections at Luwero hospital
(Makerere University, 2023-11-14)Background: A surgical site infection (SSI) is an infection that develops within at most 30 days following a surgical procedure or after one year in case if an implant was placed. The American Centers for Disease Control ... -
Bacterial-Derived Outer Membrane Vesicles in Chronic Obstructive Pulmonary Disease and HIV Infection in a Ugandan Population
(Makerere University, 2023-11-01)Background: The prevalence of chronic obstructive pulmonary disease (COPD) has increased among people living with HIV (PLWH) despite the global scale-up of antiretroviral therapy (ART). Currently, it is not fully known ... -
Diagnostic performance evaluation of lateral flow florescence immunoassay (LFIA)- based point-of-care platforms in the measurement of selected cancer makers; PSA, CEA and CA125
(Makerere University, 2023-11-14)Background: In Uganda, cancer diagnosis has been largely dependent on conventional methods such as histopathology. These methods although very accurate they however require specialized facilities with trained personnel ... -
Human Cytomegalovirus infection in febrile patients with hematological malignancies at Uganda Cancer Institute
(2017-11-14)Background: Sub-Saharan Africa is experiencing a marked increase in the burden of cancer-related morbidity and mortality, with more than 1 million incident cancers and nearly 800 000 cancer-related deaths projected annually ... -
Characterizing microbial diversity and resistome in urban sewage using shotgun metagenomics in Kampala, Uganda
(Makerere University, 2023-05)Introduction: Recently, antimicrobial resistant (AMR) infections have shown up as the leading threat to human health, having 700,000 directly attributed estimated deaths per year worldwide. For Africa, AMR data is still ... -
Genomic study of Klebsiella pnuemoniae from neonatal invasive, neonatal and maternal carriage at Kawempe National Referral Hospital, Uganda
(Makerere University, 2023-11-14)Neonatal infections particularly bloodstream infections (BSI) pose a significant health risk, necessitating a comprehensive understanding of the genetic characteristics of causative strains for effective treatment and ... -
Bacille calmette-guérin, diphtheria-tetanus, and measles vaccine responses of infants born to mothers with active tuberculosis disease
(Makerere University, 2023-11-14)Background: Babies born to mothers with active tuberculosis disease (ATB) are at risk of poor clinical outcomes such as low birth weight and perinatal mortality. However, little is known about the influence of maternal ... -
Prevalence of protective levels of anti-HBs antibodies among 15-17 year old adolescents at kawempe division,Kampala,Uganda
(Makerere University, 2023-11-04)BACKGROUND: Viral hepatitis is a global pandemic and HBV is one of the leading causes of liver-related cancer and cirrhosis. The inclusion of the HBV vaccine in National Immunization programs has contributed to the reduction ... -
Moral distress and coping strategies among nurses and midwives at Kawempe National Referral Hospital Kampala District
(Makerere University, 2023-07-28)Background: Moral distress is a major issue in nursing practice, especially for those in clinical care. The existence of such distress may affect nurses’ physical and mental health, as well as their quality of life and ... -
Binding characteristics of selected commercial antibodies against recombinant HIV Subtype D P24 antigens
(Makerere University, 2023-01)The standard method for monitoring HIV treatment response is quantitative RT-PCR, but it is difficult to implement in low and middle income countries due to infrastructure and personnel requirements. Point of care technologies ... -
Characterisation of Candida africana among pregnant women with vaginitis
(Makerere University, 2023-11)Candida africana, an emerging variant within the Candida albicans complex, has a global intra-albicans complex prevalence of 1.67% and varies between 0% and 8.4% depending on the region. It mainly causes vulvovaginal ...