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dc.contributor.authorMeintjes, Graeme
dc.contributor.authorLawn, Stephen D.
dc.contributor.authorScano, Fabio
dc.contributor.authorMaartens, Gary
dc.contributor.authorFrench, Martyn A.
dc.contributor.authorWorodria, William
dc.contributor.authorElliott, Julian H.
dc.contributor.authorMurdoch, David
dc.contributor.authorWilkinson, Robert J.
dc.contributor.authorSeyler, Catherine
dc.contributor.authorJohn, Laurence
dc.contributor.authorLynen, Lut
dc.contributor.authorJanoff, Edward N.
dc.contributor.authorGilks, Charles
dc.contributor.authorColebunders, Robert
dc.contributor.authorvan der Loeff, Maarten Schim
dc.date.accessioned2012-05-28T10:02:54Z
dc.date.available2012-05-28T10:02:54Z
dc.date.issued2008-08
dc.identifier.citationMeintjes, G., Lawn, S.D., Scano, F., Maartens, G., French, M.A., Worodria, W., Elliott, J.H., Murdoch, D., Wilkinson, R.J., Seyler, C., John, L., van der Loeff, M.S., Lynen, L., Janoff, E.N., Gilks, C., Colebunders, R. (2008). Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infectious Diseases, 8en_US
dc.identifier.issn1473-3099
dc.identifier.urihttp://hdl.handle.net/10570/595
dc.description.abstractThe immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there are no consensus case definitions for IRIS or tuberculosis-associated IRIS. Moreover, previously proposed case definitions are not readily applicable in settings where laboratory resources are limited. As a result, existing studies on tuberculosis-associated IRIS have used a variety of non-standardized general case definitions. To rectify this problem, around 100 researchers, including microbiologists, immunologists, clinicians, epidemiologists, clinical trialists, and public-health specialists from 16 countries met in Kampala, Uganda, in November, 2006. At this meeting, consensus case defi nitions for paradoxical tuberculosis-associated IRIS, ART-associated tuberculosis, and unmasking tuberculosis-associated IRIS were derived, which can be used in high-income and resource-limited settings. It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardization and comparability of data.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectInflammatory syndromeen_US
dc.subjectImmune reconstitutionen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectARTen_US
dc.subjectHIV/AIDSen_US
dc.titleTuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settingsen_US
dc.typeJournal article, peer revieweden_US


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