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    Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings

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    Meintjes-Graeme-idi-res1.pdf (209.5Kb)
    Date
    2008-08
    Author
    Meintjes, Graeme
    Lawn, Stephen D.
    Scano, Fabio
    Maartens, Gary
    French, Martyn A.
    Worodria, William
    Elliott, Julian H.
    Murdoch, David
    Wilkinson, Robert J.
    Seyler, Catherine
    John, Laurence
    Lynen, Lut
    Janoff, Edward N.
    Gilks, Charles
    Colebunders, Robert
    van der Loeff, Maarten Schim
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    Abstract
    The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there are no consensus case definitions for IRIS or tuberculosis-associated IRIS. Moreover, previously proposed case definitions are not readily applicable in settings where laboratory resources are limited. As a result, existing studies on tuberculosis-associated IRIS have used a variety of non-standardized general case definitions. To rectify this problem, around 100 researchers, including microbiologists, immunologists, clinicians, epidemiologists, clinical trialists, and public-health specialists from 16 countries met in Kampala, Uganda, in November, 2006. At this meeting, consensus case defi nitions for paradoxical tuberculosis-associated IRIS, ART-associated tuberculosis, and unmasking tuberculosis-associated IRIS were derived, which can be used in high-income and resource-limited settings. It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardization and comparability of data.
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    http://hdl.handle.net/10570/595
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