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dc.contributor.authorAlupo, Patricia
dc.date.accessioned2017-04-12T08:15:00Z
dc.date.available2017-04-12T08:15:00Z
dc.date.issued2015-05
dc.identifier.citationAlupo, P. (2015). Immunological and clinical profiles of asymptomatic cryptococcal antigenemia in HIV/AIDS patients in Uganda. Master's thesis, Makerere University, Kampala, Uganda.en_US
dc.identifier.urihttp://hdl.handle.net/10570/5575
dc.descriptionResearch dissertation submitted in partial fulfillment of the requirements for the award of a Degree of Masters of Medicine in Internal Medicine of Makerere University, Kampalaen_US
dc.description.abstractCryptococcal meningitis (CM), which is caused by the fungus, Cryptococcus Neoformans, causes life-threatening inflammation of the meninges and sometimes inflammation of the brain parenchyma. Asymptomatic cryptococcal antigenemia (CA) precedes CM by a median period of about 22days and an independent predictor of mortality in otherwise asymptomatic HIV patients. Without treatment with anti-fungal treatmentand/or ART, 100% of individuals with asymptomatic antigenemia progress to CM, however, even on treatment, about 28% progress to CM. These observations suggest that host immune responses and not just antigen burden are pivotal in the control of cryptococcal infection. The specific immunological responses important for CA control remain poorly understood. A better understanding of the immunological processes in cryptococcal infection could help predict progression from asymptomatic disease to overt cryptococcal meningitis. It could also inform us on the potential for developing immune therapies in the management of cryptococcal infection.en_US
dc.description.sponsorshipORCAS COAT Global Health Ugandaen_US
dc.language.isoenen_US
dc.publisherMakerere Universityen_US
dc.subjectCryptococcal meningitisen_US
dc.subjectCryptococcal antigenemiaen_US
dc.subjectAsymptomatic HIV patientsen_US
dc.subjectCryptococcal infectionen_US
dc.titleImmunological and clinical profiles of asymptomatic cryptococcal antigenemia in HIV/AIDS patients in Ugandaen_US
dc.typeThesis/Dissertation (Masters)en_US


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