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dc.contributor.authorBoivin, Michael J.
dc.contributor.authorBangirana, Paul
dc.contributor.authorByarugaba, Justus
dc.contributor.authorOpoka, Robert O.
dc.contributor.authorIdro, Richard
dc.contributor.authorJurek, Anne M.
dc.contributor.authorChandy, C. John
dc.date.accessioned2012-04-10T10:12:21Z
dc.date.available2012-04-10T10:12:21Z
dc.date.issued2007-01-15
dc.identifier.citationBoivin, M. J. et al (2007). Cognitive impairment after cerebral malaria in children: a prospective study. Pediatrics, 119; 360-366en_US
dc.identifier.issn1098-4275
dc.identifier.issn0031-4005
dc.identifier.urihttp://doi.dx.org10.1542/peds.2006-2027
dc.identifier.urihttp://www.pediatrics.org/cgi/content/full/119/2/e360
dc.identifier.urihttp://hdl.handle.net/10570/526
dc.description.abstractOBJECTIVE. This study was conducted to assess prospectively the frequency of cognitive deficits in children with cerebral malaria. METHODS. Cognitive testing in the areas of working memory, attention, and learning was performed for Ugandan children 5 to 12 years of age with cerebral malaria (n 44), children with uncomplicated malaria (n 54), and healthy community children (n 89) at admission and 3 and 6 months later. RESULTS. Six months after discharge, 21.4% of children with cerebral malaria had cognitive deficits, compared with 5.8% of community children. Deficits were seen in the areas of working memory (11.9% vs 2.3%) and attention (16.7% vs 2.3%). Children with cerebral malaria had a 3.7-fold increased risk of a cognitive deficit, compared with community children, after adjustment for age, gender, nutritional status, school level, and home environment. Among children with cerebral malaria, those with a cognitive deficit had more seizures before admission (mean: 4.1 vs 2.2) and a longer duration of coma (43.6 vs 30.5 hours), compared with those without a deficit. Children with uncomplicated malaria did not have an increased frequency of cognitive deficits. CONCLUSIONS. Cerebral malaria may be a major cause of cognitive impairment in children in sub-Saharan Africa. Cognitive deficits in children with cerebral malaria are more likely for those who have multiple seizures before effective treatment for cerebral malaria.en_US
dc.language.isoenen_US
dc.publisherAmerican Academy of Pediatricsen_US
dc.subjectCerebral malariaen_US
dc.subjectCognitiveen_US
dc.subjectDeficiten_US
dc.subjectImpairmenten_US
dc.subjectSequelaeen_US
dc.titleCognitive impairment after cerebral malaria in children: a prospective studyen_US
dc.typeJournal article, peer revieweden_US


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