|dc.contributor.author||Mwaka, Amos Deogratius||
|dc.identifier.citation||Bayo P, et al (2014). High prevalence of hepatitis B virus infection among pregnant women attending antenatal care: a cross-sectional study in two hospitals in northern Uganda, BMJ Open : 1-8||en_US
|dc.description.abstract||Objective: To determine the prevalence of the hepatitis
B viral (HBV) infection and hepatitis B e antigen (HBeAg)
positivity among pregnant women attending antenatal
clinics in two referral hospitals in northern Uganda.
Design: Cross-sectional observational study.
Setting: Two tertiary hospitals in a postconflict region in
a low-income country.
Participants: Randomly selected 402 pregnant women
attending routine antenatal care in two referral hospitals.
Five women withdrew consent for personal reasons. Data
were analysed for 397 participants.
Primary outcome: Hepatitis B surface antigen (HBsAg)
positivity. Results: Of 397 pregnant women aged 13–43 years,
96.2% were married or cohabiting. 47 (11.8%) tested
positive for HBsAg; of these, 7 (14.9%) were HBeAg
positive. The highest HBsAg positivity rate was seen in
women aged 20 years or less (20%) compared with
those aged above 20 years (8.7%), aOR=2.54 (95% CI
1.31 to 4.90). However, there was no statistically
significant difference between women with positive
HBsAg and those with negative tests results with respect
to median values of liver enzymes, haemoglobin level,
absolute neutrophil counts and white cell counts. HIV
positivity, scarification and number of sexual partners
were not predictive of HBV positivity. Conclusions: One in eight pregnant women attending
antenatal care in the two study hospitals has evidence of
hepatitis B infection. A significant number of these
mothers are HBeAg positive and may be at increased risk
of transmitting hepatitis B infection to their unborn
babies. We suggest that all pregnant women attending
antenatal care be tested for HBV infection; exposed
babies need to receive HBV vaccines at birth.||en_US
|dc.description.sponsorship||This work was supported by Training Health Researchers into
Vocational Excellence in East Africa (THRiVE), grant number 087540 funded
by the Wellcome Trust.||en_US
|dc.subject||Hepatitis B virus||en_US
|dc.title||High prevalence of hepatitis B virus infection among pregnant women attending antenatal care: a cross-sectional study in two hospitals in northern Uganda||en_US