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dc.contributor.authorMuyimbo, Timothy
dc.date.accessioned2015-02-25T05:56:20Z
dc.date.available2015-02-25T05:56:20Z
dc.date.issued2014
dc.identifier.citationMuyimbo, T. (2014). Evaluation of efficacy and safety of labour analgesia by intrathecal morphine with fentanyl compared to morphine with bupivacaine in Mulago Hospital: A double blinded randomized control trial. Unpublished masters thesis. Makerere University, Kampala, Uganda.en_US
dc.identifier.urihttp://hdl.handle.net/10570/4341
dc.descriptionA thesis submitted in partial fulfillment of the requirements for the award of the Masters of Medicine Degree in Anaesthesia and Critical Care of Makerere University.en_US
dc.description.abstractPain during labour is severe and in developed countries, is always treated with methods including neuraxial techniques such as combined spinal epidural analgesia. This improves maternal satisfaction with the birthing process. Studies have been done that show ITN is a cheaper yet efficacious alternative in settings where the more expensive therapeutic is not feasible. Several studies found that many African women would desire to have labour analgesia if given the opportunity. Similarly a study by Dr Nabukenya, 2013 in Mulago showed 87.91% of the participants wanted labour analgesia for their next delivery. In Mulago hospital no such service exists despite presence of anaethesiologists and obstetricians with the knowledge, skills of the different possible techniques and availability of medications that can be used in single dose spinal analgesia to treat labour pain. Opoids or local anaethetics can be used, alone or in combination. In combination, smaller doses are needed to have prolonged synergistic effects. A major limitation in Mulago was unavailability of long acting intrathecal morphine but it’s now available. After this study, information will be available regarding how efficacious and safe use of intrathecal morphine in combination with another short acting opoid or local anaesthetic is, in an effort to start a labour analgesia service in Mulago. General objective was to evaluate the efficacy and safety of intrathecal morphine-fentanyl as single dose spinal analgesia in comparison to morphine-bupivacaine regarding duration of analgesia, occurrence of side effects, fetal outcome and maternal satisfaction. It was a double blinded randomized control trial at Mulago hospital labour ward. Parturients in active normal labour were recruited. Sampling was done consecutively on those who accepted ITN, followed by block randomization until the sample size of 138 was achieved. Data was collected by piloted questionnaires, entered into Epi data version 3.1, analyzed by Stata version 12 and disseminated to directorate of research, school of postgraduate studies Makerere University. Study was conducted from 28th January to 10th March 2014. 138 parturients were recruited with 69 being block randomized to each arm. The mean duration of analgesia was, 3.80 (0.70) hours, 132 (95.65%) of the parturients had onset of analgesia within five minutes, more than 92% of parturients were very satisfied with the analgesia and more than 97% said to recommend it to their friends. The study demonstrated no significant difference in the level of side effects either to paturients or fetus. Both combinations give adequate duration of analgesia. It’s cheap and effective with high maternal satisfaction. For both drug combinations, there are no serious fetal effects.en_US
dc.description.sponsorshipAAGBIen_US
dc.language.isoenen_US
dc.publisherMakerere Universityen_US
dc.subjectLabour painsen_US
dc.subjectUterine contractionen_US
dc.subjectAfrican womenen_US
dc.subjectLabour analgesiaen_US
dc.titleEvaluation of efficacy and safety of labour analgesia by intrathecal morphine with fentanyl compared to morphine with bupivacaine in Mulago Hospital: A double blinded randomized control trial.en_US
dc.typeThesisen_US


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