College of Health Sciences (CHS): Recent submissions
Now showing items 1-20 of 3353
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Identification of pathogen genomic differences that impact human immune response and disease during cryptococcus neoformans infection
(American Society for Microbiology, 2019)Patient outcomes during infection are due to a complex interplay between the quality of medical care, host immunity factors, and the infecting pathogen’s characteristics. To probe the influence of pathogen genotype on human ... -
Assessment of parasite clearance following treatment of severe malaria with intravenous artesunate in Ugandan children enrolled in a randomized controlled clinical trial
(BMC, 2018)Background Malaria control largely depends on availability of highly efficacious drugs, however, over the years, has been threatened by emergence of drug resistance. It is, therefore, important to monitor the impact of ... -
Contrasting impact of rural, versus urban, living on glucose metabolism and blood pressure in Uganda
(Wellcome Open research, 2020)Background: The burden of cardiometabolic diseases, including cardiovascular diseases and diabetes, is increasing in sub-Saharan Africa and this has been linked to urbanisation. Helminths, through their immunomodulatory ... -
Defining gaps in pre-exposure prophylaxis delivery for pregnant and post-partum women in high-burden settings using an implementation science framework
(Elsevier, 2020)Pregnancy is a high-risk period for HIV acquisition in African women, and pregnant women who become acutely infected with HIV account for up to a third of vertical HIV transmission cases in African settings. To protect ... -
Sustained positive impact on tuberculosis treatment outcomes of TB-HIV integrated care in Uganda
(The Union, 2019)OBJECTIVE: To examine tuberculosis (TB) treatment outcomes from a long-term TB-HIV (human immunodeficiency virus) integrated model of care at the Infectious Diseases Institute Clinic, Kampala, Uganda. METHODS: We included ... -
Performance of lipoarabinomannan assay using cerebrospinal fluid for the diagnosis of tuberculous meningitis among HIV patients
(Wellcome Open Research, 2019)Background: The diagnostic utility of the Mycobacteria tuberculosis lipoarabinomannan (TB-LAM) antigen lateral flow assay on cerebrospinal fluid (CSF) for the diagnosis of tuberculous meningitis (TBM) has not been extensively ... -
A public health approach to cervical cancer screening in Africa through community-based self-administered HPV testing and mobile treatment provision
(Wiley, 2020)The World Health Organization (WHO) refers to cervical cancer as a public health problem, and sub-Saharan Africa bears the world's highest incidence. In the realm of screening, simplified WHO recommendations for low-resource ... -
Castelnuovo, B. et al. (2018). Antiretroviral treatment Long-Term (ALT) cohort: a prospective cohort of 10 years of ART-experienced patients in Uganda
(BMJ, 2018)Purpose Little information is available on patients on antiretroviral treatment (ART) after a long-term period from sub-Saharan Africa, with the longest follow-up and related outcomes being after 10 years on ART. At the ... -
A Prospective Evaluation of a multisite Cryptococcal Screening and Treatment program in HIV clinics in Uganda
(Lippincott, 2018)Background—Cryptococcus is a leading cause of AIDS-related mortality. Cryptococcal antigen (CrAg) is detectable in blood before meningitis onset, and predicts death. CrAg screening amongst those with advanced HIV, and ... -
Adolescent pregnancy at antiretroviral therapy (ART) initiation: a critical barrier to retention on ART
(Wiley Online Library, 2018)Introduction: Adolescence and pregnancy are potential risk factors for loss to follow-up (LTFU) while on antiretroviral therapy (ART). We compared adolescent and adult LTFU after ART initiation to quantify the impact of ... -
Issues with measuring hepatitis prevalence in resource-limited settings
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Molecular tests expedite the diagnosis of multidrug-resistant tuberculosis in childhood
(Academia.edu, 2018)The diagnosis of paediatric tuberculosis (TB) is difficult, partly due to the low accuracy of traditional tests. Molecular TB tests can diagnose presumptive TB and drug-resistant TB (DR-TB) rapidly and may guide crucial ... -
Risk factors for and types of oesophageal cancer
(The Lancet, 2004) -
Characteristics and outcomes of admitted patients infected with SARS-CoV-2 in Uganda
(BMJ, 2020)Rationale: Detailed data on the characteristics and outcomes of patients with COVID-19 in sub-Saharan Africa are limited. Objective: We determined the clinical characteristics and treatment outcomes of patients diagnosed ... -
Metabolic syndrome and 10-year cardiovascular risk among HIV-positive and HIV-negative adults: A cross-sectional study
(Wolters Kluwer, 2020)To determine the prevalence and correlates of metabolic syndrome (MetS) and compare 10-year cardiovascular disease (CVD) risk among Kenyan adults with and without HIV infection.We conducted a cross-sectional study among ... -
Intimate partner violence and self-reported pre-exposure prophylaxis interruptions among HIV-negative partners in HIV serodiscordant couples in Kenya and Uganda
(Lippincott, 2018)Background: Oral pre-exposure prophylaxis (PrEP) is effective for HIV prevention, and PrEP delivery studies are investigating ways to deliver PrEP with high adherence. However, in many settings with high HIV burden, intimate ... -
Tuberculosis preventive therapy (TPT) to prevent tuberculosis co-infection among adults with HIV-associated cryptococcal meningitis: A clinician's perspective
(Elsevier, 2020)As part of the END TB strategy, the World Health organization (WHO) recommends provision of tuberculosis preventive therapy (TPT) to all people at high risk of developing active TB disease. Patients with HIV-associated ... -
Prevalence and nature of potential drug-drug interactions among hospitalized HIV patients presenting with suspected meningitis in Uganda
(BMC, 2020)Background: Management of co-infections including cryptococcal meningitis, tuberculosis and other opportunistic infections in persons living with HIV can lead to complex polypharmacotherapy and increased susceptibility to ... -
Prevalence and associated factors of erectile dysfunction among men attending the urology clinic at Mulago Hospital: a cross-sectional study
(Makerere University, 2025)Background: Erectile dysfunction (ED) is a significant public health concern affecting men’s quality of life and relationships. Despite its global burden, epidemiological data on ED in Uganda, particularly among men seeking ... -
Prevalence and factors associated with Hypovitaminosis D among patients with colorectal cancer in Mulago National Referral Hospital and Uganda Cancer Institute (Uganda): A cross-sectional study
(Makerere University, 2025)Introduction: The burden of colorectal cancer has increased in Uganda. Vitamin D has immunomodulatory effects that are not only protective against malignancies such as colorectal cancer but are also associated with reduced ...