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Now showing items 11-20 of 25
A metabolic biosignature of early response to anti-tuberculosis treatment
(BMC Infectious Diseases, 2014)
Background: The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacterium ...
Incidence and predictors of mortality and the effect of tuberculosis immune reconstitution inflammatory syndrome in a cohort of TB/HIV patients commencing antiretroviral therapy
(Lippincott Wilkins & Williams, 2011)
Background: Tuberculosis-HIV (TB-HIV) coinfection remains an
important cause of mortality in antiretroviral therapy (ART)
programs. In a cohort of TB-HIV–coinfected patients starting
ART, we examined the incidence and ...
Elucidating emergence and transmission of multidrug-resistant tuberculosis in treatment experienced patients by whole genome sequencing
(PLOS One, 2013)
Background: Understanding the emergence and spread of multidrug-resistant tuberculosis (MDR-TB) is crucial for its control. MDR-TB in previously treated patients is generally attributed to the selection of drug resistant ...
Non-linear mixed effects modeling of liver function biomarkers in TB-HIV patients co-treated with Rifampicin and Efavirenz based regimens
(2013-11)
Introduction
Survival has improved as a result of improved HIV therapy but liver disease remains a critical problem in HIV patients. HIV disease, ART and Tuberculosis treatments have all been documented to cause liver ...
Determinants of health related quality of life in smear positive and smear negative adult tuberculosis patients in Kampala, Uganda
(Makerere University, 2014)
Introduction/background: Smear negative Tuberculosis has been on the rise since the HIV
epidemic and is associated with poor clinical outcomes. There is limited information regarding
health related quality of life(HRQoL) ...
Factors associated with healthcare workers’ adherence to national guidelines for MDR TB surveillance in Uganda: A case study of the West Nile region
(Makerere University, 2014)
Background:
A previous history of tuberculosis (TB) treatment has been identified as a risk factor for multidrug resistant TB. Therefore these patients are a high priority group for whom culture and drug-susceptibility ...
Evaluation of the GenoType MTBDRplus v2 Line Probe Assay for Rapid Diagnosis of Multidrug Resistant Tuberculosis in Uganda
(Makerere University, 2014)
Introduction: Multidrug-resistant tuberculosis (MDR-TB) poses a major challenge to TB control due to its complex diagnostic and treatment challenges. Globally, 3.7% of new cases and 20% of previously treated cases are ...
Factors associated with missed opportunities in TB investigation in public facilities in Wakiso District
(Makerere University, 2018-11)
Introduction
Tuberculosis (TB) is a major public health problem in Uganda. The prevalence of TB in Uganda is 273/100,000. Despite the implementation of several interventions to increase TB case detection in Uganda such ...
Growth patterns and survivability of the different mycobacterium tuberculosis sub lineages predominant in peri urban Kampala
(Makerere University, 2014-05)
Background: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB) infects over 2 billion people world-wide with the vast majority of deaths from TB in the developing world. Strains of MTB vary in ...
Prevalence, Immunological and Clinical Factors Associated with Malaria Among Patients with Tuberculosis in Mulago Hospital
(Makerere University, 2018-04)
Background: Uganda is among the 30 most TB/HIV burdened countries. Similarly, Uganda ranks 9th among the 15 countries that contribute 80% of the global malaria deaths. There is a possibility of a dual infection of malaria ...