Browsing College of Health Sciences (CHS) by Author "Wabwire-Mangen, Fred"

Now showing items 1-20 of 21

    • Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda 

      Yeka, Adoke; Kamya, Moses R.; Dorsey, Grant; Talisuna, Ambrose; Lugemwa, Myers; Rwakimari, John Bosco; Staedke, Sarah G.; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Bukirwa, Hasifa (Public Library of Science, 2008-06)
      Background: Uganda recently adopted artemether-lumefantrine (AL) as the recommended first-line treatment for uncomplicated malaria. However, AL has several limitations, including a twice-daily dosing regimen, recommendation ...

    • Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. 

      Kamya, Moses.R; Yeka, Adoke; Bukirwa, Hasifa; Lugemwa, Myers; Rwakimari, John B.; Staedke, Sarah G.; Talisuna, Ambrose O.; Greenhouse, Bryan; Nosten, Francois; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Dorsey, Grant (2007-05-18)
      Objectives: To compare the efficacy and safety of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for treating uncomplicated falciparum malaria in Uganda. Design: Randomized single-blinded clinical ...

    • Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda 

      Bukirwa, Hasifa; Talisuna, Ambrose; Yeka, Adoke; Kamya, Moses R; Talisuna, Ambrose O.; Banek, Kristin; Bakyaita, Nathan; Rwakimari, John Bosco; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Dorsey, Grant; Staedke, Sarah G. (Public Library of Science, 2006-05)
      Objectives: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. Design: Randomized single-blind controlled trial. Setting: Tororo, Uganda, ...

    • Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda 

      Banek, Kristin; Yeka, Adoke; Bakyaita, Nathan; Staedke, Sarah G.; Talisuna, Ambrose; Kironde, Fred; Kamya, Moses.R; Nsobya, Samuel L.; Kilian, Albert; Slater, Madeline; Dorsey, Grant; Wabwire-Mangen, Fred; Rosenthal, Philip J.; Reingold, Arthur (Public Library of Science, 2005-07)
      Background Drug resistance in Plasmodium falciparum poses a major threat to malaria control. Combination antimalarial therapy including artemisinins has been advocated recently to improve efficacy and limit the spread of ...

    • Client and provider perspectives of the efficiency and quality of care in the context of rapid scale-up of antiretroviral therapy 

      Amanyire, Gideon; Wanyenze, Rhoda; Alamo, Stella; Kwarisiima, Dalsone; Sunday, Pamella; Sebikaari, Gloria; Kamya, Moses; Wabwire-Mangen, Fred; Wagner, Glenn (Mary Ann Liebert, 2010)
      Global scale-up of antiretroviral therapy (ART) has focused on clinical outcomes with little attention on its impact on existing health systems. In June–August 2008, we conducted a formative evaluation on ART scale-up and ...

    • Discontinuation of cost sharing in Uganda 

      Pariyo, George W.; Burnham, Gilbert M.; Galiwango, Edward; Wabwire-Mangen, Fred (World Health Organization, 2003-09-15)
      Objective: To assess the effects of ending cost sharing on use of outpatient services and how this was perceived by health workers and members of a health unit management committee. Methods: From 10 districts across Uganda, ...

    • Do religion and religiosity have anything to do with alcohol consumption patterns? Evidence from two fish landing sites on Lake Victoria, Uganda 

      Tumwesigye, Nazarius M.; Atuyambe, Lynn; Kibira, Simon P. S.; Wabwire-Mangen, Fred; Tushemerirwe, Florence; Wagner, Glenn J. (Informa Healthcare, 2013)
      Fish landing sites have high levels of harmful use of alcohol. This paper examines the role of religion and religiosity on alcohol consumption at two fish landing sites on Lake Victoria in Uganda. Questionnaires were ...

    • The effects of enhanced access to antiretroviral therapy: a qualitative study of community perceptions in Kampala city, Uganda 

      Atuyambe, Lynn; Neema, Stella; Otolok-Tanga, Erasmus; Wamuyu-Maina, Gakenia; Kasasa, Simon; Wabwire-Mangen, Fred (Makerere University Medical School, 2008)
      Introduction: Since 2001, Antiretroviral Therapy (ART) has been integrated as part of the Uganda National Program for Comprehensive HIV/AIDS Care and Support. If patients take Antiretroviral drugs (ARVs) as prescribed, ...

    • The effects of male circumcision on female partner's genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda 

      Kigozi, Godfrey; Gray, Ronald H.; Serwadda, David; Makumbi, Frederick; Nalugoda, Fred; Watya, Stephen; Moulton, Laurence; Chen, Michael Z.; Sewankambo, Nelson K.; Kiwanuka, Noah; Sempijja, Victor; Kagayii, Joseph; Wabwire-Mangen, Fred; Ridzon, Renee; Bacon, Melanie; Williams, Caroline; Wawer, Maria J. (Elsevier, 2009)
      Objective—To assess effects of male circumcision on female genital symptoms, and vaginal infections. Methods—HIV-negative men enrolled in a trial were randomized to immediate or delayed circumcision (control arm). Genital ...

    • The effects of male circumcision on female partners’ genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda 

      Grey, Ronald H.; Kigozi, Godfrey; Serwadda, David; Makumbi, Frederick; Nalugoda, Fred; Watya, Stephen; Moulton, Laurence; Chen, Michael Z.; Sewankambo, Nelson K.; Kiwanuka, Noah; Sempijja, Victor; Lutalo, Tom; Kagayii, Joseph; Wabwire-Mangen, Fred; Ridzon, Renée; Bacon, Melanie (Elsevier Commercial Publisher, 2009-01)
      OBJECTIVE: The objective of the study was to assess effects of male circumcision on female genital symptoms and vaginal infections. STUDY DESIGN: Human immunodeficiency virus (HIV)-negative men enrolled in a trial were ...

    • Elevated natural killer cell activity despite altered functional and phenotypic profile in Ugandans with HIV-1 Clade A or Clade D infection. 

      Eller, Michael A.; Eller, Leigh Anne; Ouma, Benson J.; Thelian, Doris; Gonzalez, Veronica D.; Guwatudde, David; Currier, Jeffrey R.; McCutchan, Francine E.; Marovich, Mary A.; Michael, Nelson L.; de Souza, Mark S.; Wabwire-Mangen, Fred; Robb, Merlin L.; Sandberg, Johan K. (Lippincott Williams & Wilkins, 2009)
      Background and Objective: Natural killer (NK) cells most likely contribute toward limiting HIV-1 replication, and investigation into their function throughout the course of infection is therefore important. We here aimed ...

    • Endemic, emerging and re-emerging communicable diseases in Uganda 

      Wabwire-Mangen, Fred; Wamuyu-Maina, Gakenia (SAGE, 2009)
      Fred Wabwire-Mangen and Gakenia Wamuyu Maina review the environmental, social and political factors that explain the inequitable distribution of communicable disease burden in Uganda.

    • Large-scale human immunodefficiecy virus rapid test evaluation in a low-prevalence Ugandan blood bank population 

      Eller, Leigh A.; Eller, Michael A.; Ouma, Benson J.; Kataaha, Peter; Bagaya, Bernard S.; Olemukan, Robert L.; Erima, Simon; Kawala, Lillian; de Souza, Mark S.; Kibuuka, Hannah; Wabwire-Mangen, Fred; Peel, Sheila A.; O'Connell, Robert J.; Robb, Merlin L.; Michael, Nelson L. (American Society for Microbiology, 2007-10)
      The use of rapid tests for human immunodeficiency virus (HIV) has become standard in HIV testing algorithms employed in resource-limited settings. We report an extensive HIV rapid test validation study conducted among ...

    • Molecular epidemiology of Influenza A/H3N2 viruses circulating in Uganda 

      Byarugaba, Denis K.; Ducatez, Mariette F.; Erima, Bernard; Mworozi, Edson A.; Millard, Monica; Kibuuka, Hannah; Lukwago, Luswa; Bwogi, Josephine; Kaira, Blanche B.; Mimbe, Derrick; Webby, Richard J.; Krauss, Scott; Schnabel, David C.; Darnell, Daniel; Webster, Robert G.; Wabwire-Mangen, Fred (Public Library of Science, 2011-11-21)
      The increasing availability of complete influenza virus genomes is deepening our understanding of influenza evolutionary dynamics and facilitating the selection of vaccine strains. However, only one complete African influenza ...

    • The Safety of adult male circumcision in HIV-infected and uninfected men in Rakai, Uganda 

      Kigozi, Godfrey; H. Gray, Ronald; Wawer, Maria J.; Serwadda, David; Makumbi, Frederick; Watya, Stephen; Nalugoda, Fred; Kiwanuka, Noah; Moulton, Lawrence H.; Chen, Michael Z.; Sewankambo, Nelson K; Wabwire-Mangen, Fred; Bacon, Melanie C.; Ridzon, Renee; Opendi, Pius; Sempijja, Victor; Settuba, Absolom; Buwembo, Denis; Kiggundu, Valerian; Anyokorit, Margaret; Nkale, James; Kighoma, Nehemia; Charvat, Blake (Public Library of Science, 2008-06-03)
      Background: The objective of the study was to compare rates of adverse events (AEs) related to male circumcision (MC) in HIV-positive and HIV-negative men in order to provide guidance for MC programs that may provide ...

    • The safety of adult male circumcision in HIV-infected and uninfected men in Rakai, Uganda. 

      Kigozi, Godfrey; Gray, Ronald H.; Wawer, Maria J.; Serwadda, David; Makumbi, Frederick; Watya, Stephen; Nalugoda, Fred; Kiwanuka, Noah; Moulton, Lawrence H.; Chen, Michael Z.; Sewankambo, Nelson K.; Wabwire-Mangen, Fred; Bacon, Melanie C.; Ridzon, Renee; Opendi, Pius; Sempijja, Victor; Settuba, Absolom; Buwembo, Denis; Kiggundu, Valerian; Anyokorit, Margaret; Nkale, James; Kighoma, Nehemia; Charvat, Blake (Public Library of Science, 2008-06)
      Background The objective of the study was to compare rates of adverse events (AEs) related to male circumcision (MC) in HIV-positive and HIV-negative men in order to provide guidance for MC programs that may provide ...

    • Short report: assessing the impact of indoor residual spraying on malaria morbidity using a sentinel site surveillance system in Western Uganda 

      Bukirwa, Hasifa; Yau, Vincent; Kigozi, Ruth; Filler, Scott; Quick, Linda; Lugemwa, Myers; Dissanayake, Gunawardena; Kamya, Moses; Wabwire-Mangen, Fred; Dorsey, Grant (American Society of Tropical Medicine and Hygiene, 2009)
      A single round of indoor residual spraying (IRS) using lambda-cyhalothrin was implemented in a district of Uganda with moderate transmission intensity in 2007. Individual patient data were collected from one health facility ...

    • Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda 

      Bakyaita, Nathan; Dorsey, Grant; Adoke, Yeka; Banek, Kristin; Staedke, Sarah G.; Kamya, Moses R.; Talisuna, Ambrose; Kironde, Fred; Nsobya, Sam; Kilian, Albert; Reingold, Arthur; Rosenthal, Philip J.; Wabwire-Mangen, Fred (2005)
      The use of combinations of inexpensive drugs for the treatment of malaria in Africa has been proposed as an interim policy while awaiting the widespread availability of more effective regimens. We compared sulfadoxinepyrimethamine ...

    • Survival of infants born to HIV-positive mothers, by feeding modality, in Rakai, Uganda 

      Kagaayi, Joseph; Gray, Ronald H.; Brahmbhatt, Heena; Kigozi, Godfrey; Nalugoda, Fred; Wabwire-Mangen, Fred; Serwadda, David; Sewankambo, Nelson; Ddungu, Veronica; Ssebagala, Darix; Sekasanvu, Joseph; Kigozi, Grace; Makumbi, Fredrick; Kiwanuka, Noah; Lutalo, Tom; Reynolds, Steven J.; Wawer, Maria J. (Public Library of Science, 2008-12-09)
      Background: Data comparing survival of formula-fed to breast-fed infants in programmatic settings are limited. We compared mortality and HIV-free of breast and formula-fed infants born to HIV-positive mothers in a program ...

    • Type-specific incidence, clearance and predictors of cervical human papillomavirus infections (HPV) among young women: a prospective study in Uganda. 

      Banura, Cecil; Sandin, Sven; van Doorn, Leen-Jan; Quint, Wim; Kleter, Bernhard; Wabwire-Mangen, Fred; Mbidde, Edward K; Weiderpass, Elisabete (BioMed Central, 2010)
      Background: While infections with human papillomavirus (HPV) are highly prevalent among sexually active young women in Uganda, information on incidence, clearance and their associated risk factors is sparse. To estimate ...