Browsing College of Health Sciences (CHS) by Subject "Tuberculosis"
Now showing items 1-20 of 48
-
Assessment of the implementation of tuberculosis (TB) communty based directly observed treatemtn, (CB-DOTS), in Tororo District, Uganda
(2007-05)INTRODUCTION AND BACKGROUND: Tuberculosis (TB) affects 20 million people the world over. Uganda is among the 22 high burden countries (HBC) and is ranked 16th in the global TB control. Community based directly observed ... -
Bronchoscopy is useful for diagnosing smear-negative tuberculosis in HIV-infected patients
(European Respiratory Journal, 2010) -
Burden of tuberculosis in Kampala, Uganda
(World Health Organization (WHO), 2008)Objective: To determine the prevalence and incidence of tuberculosis in one of Uganda’s poor peri-urban areas. Methods: Multi-stage sampling was used to select a sample of households whose members were evaluated for presence ... -
A comparison of sodium hypochlorite n-acetyl-l-cystein sputum concentration methods and culture for diagnosis of smear negative pulmonary tuberculosis suspects attending Mulago hospital.
(2005)The sensitivity of direct sputum smear microscopy is very low, ranging from 25 to 65%. It is thus inevitable that direct smear microscopy needs to be improved or other methods of diagnosis of smear negative (TB) be designed. ... -
Determinants of health related quality of life in smear positive and smear negative adult tuberculosis patients in Kampala, Uganda
(Makerere University, 2014)Introduction/background: Smear negative Tuberculosis has been on the rise since the HIV epidemic and is associated with poor clinical outcomes. There is limited information regarding health related quality of life(HRQoL) ... -
The diagnosis of childhood tuberculosis in an HIV-endemic setting and the use of induced sputum
(International Union Against Tuberculosis and Lung Disease, 2005)Setting: A hospital in the capital city of Uganda. Objectives: To determine the proportion of positive induced sputum cultures among probable childhood tuberculosis (TB) cases, to describe the laboratory and radiological ... -
Digital clubbing in tuberculosis – relationship to HIV infection, extent of disease and hypoalbuminemia
(BioMed Central, 2006-03-10)Background: Digital clubbing is a sign of chest disease known since the time of Hippocrates. Its association with tuberculosis (TB) has not been well studied, particularly in Africa where TB is common. The prevalence of ... -
The effect of AIDS defining conditions on immunological recovery among patients initiating antiretroviral therapy at Joint Clinical Research Centre, Uganda
(BioMed Central, 2009-07-24)Background: Many HIV-infected patients only access health care once they have developed advanced symptomatic disease resulting from AIDS Defining Conditions (ADCs). We carried out a study to establish the effect of ADCs ... -
The effect of bacille Calmette-Guérin vaccination at birth on tuberculin skin test reactivity in Ugandan children
(International Union Against Tuberculosis and Lung Disease, 1999)SETTING: In Uganda, bacille-Calmette Guérin (BCG) vaccination coverage at birth is between 82 and 84%. OBJECTIVE: To evaluate the effect of neonatal BCG vaccination on tuberculin skin test positivity in Ugandan children ... -
Elucidating emergence and transmission of multidrug-resistant tuberculosis in treatment experienced patients by whole genome sequencing
(PLOS One, 2013)Background: Understanding the emergence and spread of multidrug-resistant tuberculosis (MDR-TB) is crucial for its control. MDR-TB in previously treated patients is generally attributed to the selection of drug resistant ... -
Evaluation of suspected tuberculous pleurisy: clinical and diagnostic findings in HIV-1-positive and HIV-negative adults in Uganda
(International Union Against Tuberculosis and Lung Disease, 2001-04)SETTING: National Tuberculosis Treatment Centre, Mulago Hospital, Kampala, Uganda. OBJECTIVES: To compare clinical and radiographic presentation, and diagnostic methods, in adults with tuberculous pleurisy who are negative ... -
Evaluation of the GenoType MTBDRplus v2 Line Probe Assay for Rapid Diagnosis of Multidrug Resistant Tuberculosis in Uganda
(Makerere University, 2014)Introduction: Multidrug-resistant tuberculosis (MDR-TB) poses a major challenge to TB control due to its complex diagnostic and treatment challenges. Globally, 3.7% of new cases and 20% of previously treated cases are ... -
Factors affecting use of community based tuberculosis care in kampala district, uganda.
(2007-11)Tuberculosis(T.B)is among the leading causes of mortality and affects one third of the population in the developing countries. Community based tuberculosis short course therapy(CBDOTS) is the most effective strategy available ... -
Factors associated with healthcare workers’ adherence to national guidelines for MDR TB surveillance in Uganda: A case study of the West Nile region
(Makerere University, 2014)Background: A previous history of tuberculosis (TB) treatment has been identified as a risk factor for multidrug resistant TB. Therefore these patients are a high priority group for whom culture and drug-susceptibility ... -
Factors associated with missed opportunities in TB investigation in public facilities in Wakiso District
(Makerere University, 2018-11)Introduction Tuberculosis (TB) is a major public health problem in Uganda. The prevalence of TB in Uganda is 273/100,000. Despite the implementation of several interventions to increase TB case detection in Uganda such ... -
Factors associated with non-enrolment of tuberculosis HIV co-infected patients on an Anti-Retroviral Therapy program at Mulago Hospital Tuberculosis Clinic
(Makerere University, 2011-10)Introduction: The high TB/HIV co-infection rate presents one of the most significant challenges to the overburdened healthcare systems in many low-income countries. However, collaborative TB/HIV treatment has not achieved ... -
Growth patterns and survivability of the different mycobacterium tuberculosis sub lineages predominant in peri urban Kampala
(Makerere University, 2014-05)Background: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB) infects over 2 billion people world-wide with the vast majority of deaths from TB in the developing world. Strains of MTB vary in ... -
Health service delay and associated factors among pulmonary tuberculosis patients presenting to Mulago Hospital: a cross sectional study.
(2009-10)Delay in the diagnosis of pulmonary tuberculosis (PTB) is common in many countries in sub-Saharan Africa. Timely diagnosis of active TB is particularly crucial to minimise not only morbidity and mortality in the community, ... -
Identification of the insertions, deletions and point mutations in rhomboid proteases from selected Mycobacterium species
(Makerere University, 2014-11)Background: Rhomboids, proteins that are conserved in all life kingdoms, are among the novel genes likely to encode roles in the pathogenesis of mycobacteria. While rhomboids have various specific functions across species, ... -
Incidence and predictors of mortality and the effect of tuberculosis immune reconstitution inflammatory syndrome in a cohort of TB/HIV patients commencing antiretroviral therapy
(Lippincott Wilkins & Williams, 2011)Background: Tuberculosis-HIV (TB-HIV) coinfection remains an important cause of mortality in antiretroviral therapy (ART) programs. In a cohort of TB-HIV–coinfected patients starting ART, we examined the incidence and ...