Browsing College of Health Sciences (CHS) by Subject "Tuberculosis"
Now showing items 1-20 of 84
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Assessing the effectiveness of contact tracing for multi drug resistant tuberculosis in Uganda
(Makerere University, 2024)Introduction: Multidrug-resistant tuberculosis (MDR-TB) poses a big threat in to the management of Tuberculosis (TB) disease in many countries including Uganda. MDR - TB can be transmitted from one person to another through ... -
Assessment of the implementation of tuberculosis (TB) communty based directly observed treatemtn, (CB-DOTS), in Tororo District, Uganda
(2007-05)INTRODUCTION AND BACKGROUND: Tuberculosis (TB) affects 20 million people the world over. Uganda is among the 22 high burden countries (HBC) and is ranked 16th in the global TB control. Community based directly observed ... -
Bronchoscopy is useful for diagnosing smear-negative tuberculosis in HIV-infected patients
(European Respiratory Journal, 2010) -
Burden of tuberculosis in Kampala, Uganda
(World Health Organization (WHO), 2008)Objective: To determine the prevalence and incidence of tuberculosis in one of Uganda’s poor peri-urban areas. Methods: Multi-stage sampling was used to select a sample of households whose members were evaluated for presence ... -
Case detection of tuberculosis patients using machine learning : a case study of China Friendship Hospital Naguru, Kampala
(Makerere University, 2021-08-18)Although early detection and treatment of Tuberculosis cases are the hallmark of successful TB control, diagnostic delay is still long and common in Uganda. Therefore, the study aimed at developing a tool that uses ... -
A comparison of frequencies and function of myeloid derived suppressor cells (MDSCS) IN TB/HIV co-infected and HIV mono-infected individuals in Uganda
(Makerere University, 2023)Background Myeloid-derived suppressor cells (MDSC) encompass a subset of myeloid cells, which suppress both innate and adaptive immune functions. These cells negatively regulate the immune function either by arginine ... -
A comparison of sodium hypochlorite n-acetyl-l-cystein sputum concentration methods and culture for diagnosis of smear negative pulmonary tuberculosis suspects attending Mulago hospital.
(2005)The sensitivity of direct sputum smear microscopy is very low, ranging from 25 to 65%. It is thus inevitable that direct smear microscopy needs to be improved or other methods of diagnosis of smear negative (TB) be designed. ... -
A comparison of Ubiquitin E3 ligases as surrogate markers for T cell Anergy in active TB
(2024-10-24)Background: Globally, there is an estimated 1.2 million TB-related deaths among HIV-negative people with active TB. Previous studies using ex-vivo and animal models indicate that CD4+ T cell unresponsiveness to Mtb, which ... -
Costs of tuberculosis care and associated factors among patients with HIV or diabetes mellitus comorbidities attending selected health facilities in Kampala from a societal perspective
(Makerere University, 2023)Introduction In Uganda, the Tuberculosis (TB) burden among Human immunodeficiency virus (HIV) patients is still high and increasing significantly among DM patients due to the looming DM epidemic. Although TB drugs and ... -
Deciphering Rifampicin resistance among Tuberculosis patients who have trace and indeterminate results on Xpert MTB/RIF ultra assay
(Makerere University, 2024-10-22)Although WHO endorsed the GeneXpert test as the first initial test for Tuberculosis diagnosis, some of the GeneXpert Ultra results include MTB detected trace, RIF resistance indeterminate which necessitates a sample rerun, ... -
Determinants of health related quality of life in smear positive and smear negative adult tuberculosis patients in Kampala, Uganda
(Makerere University, 2014)Introduction/background: Smear negative Tuberculosis has been on the rise since the HIV epidemic and is associated with poor clinical outcomes. There is limited information regarding health related quality of life(HRQoL) ... -
Developing a theory informed intervention to improve linkage to treatment for patients diagnosed with tuberculosis using XPERT® MTB/RIF testing in Central and Eastern Uganda
(Makerere University, 2022-11)Background: In 2019, Uganda notified only 74% of estimated TB cases against an END TB target of 90%. This gap between estimated incident TB cases and those accessing TB treatment is due to a combination of underdiagnosis ... -
The diagnosis of childhood tuberculosis in an HIV-endemic setting and the use of induced sputum
(International Union Against Tuberculosis and Lung Disease, 2005)Setting: A hospital in the capital city of Uganda. Objectives: To determine the proportion of positive induced sputum cultures among probable childhood tuberculosis (TB) cases, to describe the laboratory and radiological ... -
Diagnostic accuracy of anti-mycobacterial protein 51 antibodies as a biomarker for latent TB infection in asymptomatic HIV positive individuals
(Makerere University, 2024)Background: Tuberculosis (TB) continues to be a major global public health concern more so in sub-Saharan Africa and Uganda in particular due to inaccessibility to accurate, rapid and reliable diagnostic methods on top of ... -
Digital clubbing in tuberculosis – relationship to HIV infection, extent of disease and hypoalbuminemia
(BioMed Central, 2006-03-10)Background: Digital clubbing is a sign of chest disease known since the time of Hippocrates. Its association with tuberculosis (TB) has not been well studied, particularly in Africa where TB is common. The prevalence of ... -
The effect of AIDS defining conditions on immunological recovery among patients initiating antiretroviral therapy at Joint Clinical Research Centre, Uganda
(BioMed Central, 2009-07-24)Background: Many HIV-infected patients only access health care once they have developed advanced symptomatic disease resulting from AIDS Defining Conditions (ADCs). We carried out a study to establish the effect of ADCs ... -
The effect of bacille Calmette-Guérin vaccination at birth on tuberculin skin test reactivity in Ugandan children
(International Union Against Tuberculosis and Lung Disease, 1999)SETTING: In Uganda, bacille-Calmette Guérin (BCG) vaccination coverage at birth is between 82 and 84%. OBJECTIVE: To evaluate the effect of neonatal BCG vaccination on tuberculin skin test positivity in Ugandan children ... -
Effect of COVID-19 period on tuberculosis treatment success; A mixed methods study among tuberculosis patients at Jinja Regional Referral Hospital
(Makerere University, 2022-01)Introduction: Before the COVID-19 pandemic, over 4000 people were dying from TB every day. TB is still a major public health threat globally, but the TB epidemic may be exacerbated by the COVID-19 pandemic. The lockdown ... -
Effect of vitamin d binding protein gene polymorphisms and vitamin d bioavailability on cathelicidin expression in tuberculosis infection and disease
(Makerere University, 2023-01)Background: The human antimicrobial peptide cathelicidin (LL-37) is involved in host innate immunity by the after activation of Toll-like receptors (TLRs), resulting in direct killing of Mycobacterium tuberculosis (MTB). ... -
Elucidating emergence and transmission of multidrug-resistant tuberculosis in treatment experienced patients by whole genome sequencing
(PLOS One, 2013)Background: Understanding the emergence and spread of multidrug-resistant tuberculosis (MDR-TB) is crucial for its control. MDR-TB in previously treated patients is generally attributed to the selection of drug resistant ...