Browsing College of Health Sciences (CHS) by Subject "Tuberculosis"
Now showing items 21-40 of 68
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Factors associated with missed opportunities in TB investigation in public facilities in Wakiso District
(Makerere University, 2018-11)Introduction Tuberculosis (TB) is a major public health problem in Uganda. The prevalence of TB in Uganda is 273/100,000. Despite the implementation of several interventions to increase TB case detection in Uganda such ... -
Factors associated with non-enrolment of tuberculosis HIV co-infected patients on an Anti-Retroviral Therapy program at Mulago Hospital Tuberculosis Clinic
(Makerere University, 2011-10)Introduction: The high TB/HIV co-infection rate presents one of the most significant challenges to the overburdened healthcare systems in many low-income countries. However, collaborative TB/HIV treatment has not achieved ... -
Gender differences in costs and socioeconomic consequences for patients seeking TB evaluation in East and Central Uganda
(Makerere University, 2018)Introduction: Tuberculosis remains a major global public health problem with unequal distribution among men and women. Over 95% of new cases and 98% of deaths annually occur in the developing world where gender inequalities ... -
Growth patterns and survivability of the different mycobacterium tuberculosis sub lineages predominant in peri urban Kampala
(Makerere University, 2014-05)Background: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB) infects over 2 billion people world-wide with the vast majority of deaths from TB in the developing world. Strains of MTB vary in ... -
Health service delay and associated factors among pulmonary tuberculosis patients presenting to Mulago Hospital: a cross sectional study.
(2009-10)Delay in the diagnosis of pulmonary tuberculosis (PTB) is common in many countries in sub-Saharan Africa. Timely diagnosis of active TB is particularly crucial to minimise not only morbidity and mortality in the community, ... -
Identification of the insertions, deletions and point mutations in rhomboid proteases from selected Mycobacterium species
(Makerere University, 2014-11)Background: Rhomboids, proteins that are conserved in all life kingdoms, are among the novel genes likely to encode roles in the pathogenesis of mycobacteria. While rhomboids have various specific functions across species, ... -
Incidence and predictors of mortality and the effect of tuberculosis immune reconstitution inflammatory syndrome in a cohort of TB/HIV patients commencing antiretroviral therapy
(Lippincott Wilkins & Williams, 2011)Background: Tuberculosis-HIV (TB-HIV) coinfection remains an important cause of mortality in antiretroviral therapy (ART) programs. In a cohort of TB-HIV–coinfected patients starting ART, we examined the incidence and ... -
Incidence and predictors of two months’ sputum non follow-up and patients’ perceived quality of care among tuberculosis patients, Hoima District
(Makerere University, 2019-06)Introduction: The World Health Organization and Ministry of health recommend monitoring of tuberculosis patients on treatment for progress. Provision of sufficiently high tuberculosis care quality is necessary to achieve ... -
Infection of multiple strains of micobacterium tuberculosis using MIRU-VNTR in patients with pulmonary tuberculosis in Kampala, Uganmda
(BioMed Central, 2010)Background: Many studies using DNA fingerprinting to differentiate Mycobacterium tuberculosis (MTB) strains reveal single strains in cultures, suggesting that most disease is caused by infection with a single strain. ... -
Integration of HIV and TB services results in improved TB treatment outcomes and earlier prioritized ART initiation in a large urban HIV clinic in Uganda
(Lippincott, Williams & Wilkins, 2012-06-01)Background: The World Health Organization recommends that treatment of tuberculosis ... -
A metabolic biosignature of early response to anti-tuberculosis treatment
(BMC Infectious Diseases, 2014)Background: The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacterium ... -
Mycobacterium tuberculosis associated immune activation, inhibition and exhaustion profiling to predict active tuberculosis disease among presumptive tuberculosis participants and monitor anti-tuberculosis treatment response.
(Makerere University, 2023)Globally, tuberculosis (TB) is the leading cause of mortality and morbidity especially among resource-limited populations including Uganda. This statistic is greatly fueled by the delay in diagnosis of the disease and ... -
Non-adherence to tuberculosis medication among patients in Rakai and Kyotera Districts
(Makerere University, 2023-08)Introduction Poor adherence to anti-tuberculosis (TB) treatment is a bottleneck to treatment success, increases risk of community TB infection spread and fuels development drug resistance TB raising patient treatment ... -
Non-linear mixed effects modeling of liver function biomarkers in TB-HIV patients co-treated with Rifampicin and Efavirenz based regimens
(2013-11)Introduction Survival has improved as a result of improved HIV therapy but liver disease remains a critical problem in HIV patients. HIV disease, ART and Tuberculosis treatments have all been documented to cause liver ... -
Optimal number of samples required to diagnose tuberculosis by sputum culture among adult HIV infected smear negative suspects in Kampala, Uganda
(Makerere University, 2011-07)Background; The World Health Organization recommended sputum culture among smear negative HIV infected TB suspects; but the number of samples to be examined is still unspecified. A study was set out to determine the ... -
The past and present radiographic manifestations of pulmonary tuberculosis at Mulago Hospital
(1989-04)A cross-sectional study of the chest radiographs of adult tuberculosis patients, seen at Mulago Hospital, in 1972, 1979 and 1988 was carried out between August and December 1988. The aim of the study was to determine the ... -
Patient single nucleotide polymorphisms assiocated with Mycobacterium tuberculosis genotypes in Ugandan population
(Makerere University, 2022-12)Uganda is one of the 30 World Health Organization-designated countries with a high burden of TB/HIV, with three main dominant genotypes that cause tuberculosis. Recent studies have shown that the M. tuberculosis Uganda ... -
Patients' satisfaction with tuberculosis services provided at selected health facilities in Mityana District, Uganda
(Makerere University, 2022-08)Introduction The quality of Tuberculosis health care is critical for improved treatment outcomes. Patient satisfaction surveys are important indicators of the quality of services offered however, there is limited information ... -
Performance evaluation of the Uganda National Algorithm for Diagnosis of tuberculosis in children at Mulago National Referral Hospital-Kampala, Uganda
(Makerere University, 2023)Background Diagnosing childhood tuberculosis (TB) is a challenge, this led the Uganda national tuberculosis control program (NTLP) to develop a clinical treatment decision algorithm for children. However, there is limited ... -
Practices of diagnosis and treatment of pulmonary tuberculosis, associated factors, barriers and facilitators among private practitioners in Kampala, Uganda
(Makerere University, 2020-11)Introduction: Globally, tuberculosis (TB) is a leading cause of morbidity and mortality accounting for an estimated 10.0 million new cases and 1.451million deaths in 2018. Uganda is one of the world’s high TB burden countries ...