Browsing School of Medicine (Sch. of Med.) Collections by Subject "Drug resistance"
Now showing items 1-4 of 4
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Associations between aminoquinoline resistance genotypes and clinical presentations of Pplasmodium falciparum Infection in Uganda
(American Society for Microbiology., 2020)Mutations that mediate resistance of Plasmodium falciparum to aminoquinoline antimalarials are selected by prior drug use and may alter parasite fitness, but associations with clinical presentations are uncertain. We ... -
Genetic polymorphisms in plasmodium falciparum associated with resistance to artemisinin combination therapy: complexity of infection during short-term culture and characterization of in vitro sensitivity in Kampala Uganda
(Makerere University, 2010)Background: Artemisinin-based combination therapy (ACT) is currently advocated in Africa as a means of improving treatment efficacy and slowing the development of drug resistance. However, the selection of resistant ... -
Incidence and factors associated with first line antiretroviral treatment failure in children attending the Joint Clinical Research Centre Kampala, Uganda
(Makerere University, 2012)Background: The human immunodeficiency virus (HIV) disease develops very rapidly among infants and children mainly due to the immature immune system. Without treatment, half of the children die before their second birthday. ... -
Multiple HIV-1 subtype infection and transmitted drug resistance; prevalence in HIV-1 infected Ugandans and association to disease stage and progression
(Makerere University, 2011-08)Infection of an individual with two or more viral strains (dual/mixed infection) occurs in HIV-1 infection. The identification of the immunological and virological determinants of dual infection would provide data that ...