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    Total lymphocyte count: not a surrogate marker for risk of death in HIV infected Ugandan children

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    Date
    2008-10-01
    Author
    Musoke, Philippa M.
    Owor, Maxensia
    Young, Alicia M.
    Lubega, Irene R.
    Brown, Elizabeth R.
    Mmiro, Francis A.
    Mofenson, Lynne M.
    Jackson, J. Brooks
    Fowler, Mary Glenn
    Guay, Laura A.
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    Abstract
    Objectives—To determine the utility of Total Lymphocyte Count (TLC) in predicting the 12 month mortality in HIV infected Ugandan children; to correlate TLC and CD4 cell %. Design—This is a retrospective data analysis of clinical and laboratory data collected prospectively on 128 HIV infected children in the HIVNET 012 trial. Methods—TLC and CD4 cell % measurements were obtained at birth, 14 weeks and 12, 24, 36, 48, and 60 months of age and assessed with respect to risk of death within 12 months. Results—Median TLC/ul (CD4 cell %) were 4150 (41%) at birth, 4900 (24%) at 12 months, 4300 (19%) at 24 months, 4150 (19 %) at 36 months, 4100 (18%) at 48 months and 3800 (20%) at 60 months. The highest risk of mortality within 12 months was 34–37% at birth and declined to 13– 15% at 24 months regardless of TLC measurement. The correlation between CD4 cell % and TLC was extremely low overall (r = 0.01). Conclusion—The TLC did not predict a risk of progression to death within 12 months and therefore TLC alone may not be a useful surrogate marker for determining those children in greatest need for antiretroviral therapy in HIV infected Ugandan children.
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    http://hdl.handle.net/10570/1821
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