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Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda
(Public Library of Science, 2006-05)
Objectives: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. Design: Randomized single-blind controlled trial. Setting: Tororo, Uganda, ...
Complexity of plasmodium falciparum clinical samples from Uganda during short-term culture.
(University of Chicago Press, 2008-08-22)
We cultured Plasmodium falciparum parasites from 98 Ugandan children with malaria and determined the complexity of infection (COI) on the basis of msp-2 polymorphisms daily for 9 days. The mean COI decreased during culture ...
Antimalarial drug levels in biological samples: methods and applications.
(2008-09)
This thesis deals with the development and validation of analytical methods that are field-adapted and their application in the determination of antimalarial drug levels in biological samples. These methods are suitable ...
Effect of HIV-1 infection on malaria treatment outcome in Uganda patients
(Makerere University Medical School, 2007)
Background: Malaria and HIV-1 infection cause significant morbidity and mortality in sub-Saharan Africa. HIV-1 increases risk for malaria with the risk increasing as immunity declines. The effect of HIV-1 infection on ...
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.
(Oxford University Press, 2009-11-04)
Background. Amodiaquine (AQ) is paired with artesunate (AS) or sulfadoxine-pyrimethamine (SP) in recommended antimalarial regimens. It is unclear how readily AQ resistance will be selected with combination chemotherapy. ...
Can community health workers and caretakers recognise pneumonia in children? Experiences from Western Uganda
(Elsevier, 2006)
Acute respiratory infections (ARI) are leading killers of children. Case management using community health workers (CHW) has halved ARI mortality in children in Asia. WHO/UNICEF recommend integrating pneumonia into Home ...
Selection of plasmodium falciparum pfmdr1 Alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic
(American Society for Microbiology, 2006-03-08)
Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N,184F, and 1246D ...
Community effectiveness of malaria treatment in Uganda: a long way to Abuja targets
(Taylor & Francis, 2005)
Introduction: At the Roll Back Malaria summit for African countries in Abuja, the heads of state committed to ensure that by the year 2005 at least 60% of those suffering from malaria would have access to effective treatment ...
Complexity of plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda.
(University of Chicago Press, 2006-03-13)
Malaria infections in Africa frequently include multiple parasite strains.We examined the relationship between the number of infecting Plasmodium falciparum strains and the responses to 3 different combination therapies ...
Local fever illness classifications: implications for home management of malaria strategies
(Wiley-Blackwell, 2004-11)
Background: The Ugandan Ministry of Health has adopted the WHO Home Based Fever Management strategy (HBM) to improve access to antimalarial drugs for prompt (<24 h) presumptive treatment of all fevers in children under 5 ...