Show simple item record

dc.contributor.authorKiwanuka, Noah
dc.contributor.authorSsetaala, Ali
dc.contributor.authorNalutaaya, Annet
dc.contributor.authorMpendo, Juliet
dc.contributor.authorWambuzi, Matthias
dc.contributor.authorNanvubya, Annet
dc.contributor.authorSigirenda, Simon
dc.contributor.authorKato Kitandwe, Paul
dc.contributor.authorNielsen, Leslie Elizabeth
dc.contributor.authorBalyegisawa, Apolo
dc.contributor.authorKaleebu, Pontiano
dc.contributor.authorNalusiba, Josephine
dc.contributor.authorSewankambo, Nelson Kaulukusi
dc.date.accessioned2015-05-07T06:30:06Z
dc.date.available2015-05-07T06:30:06Z
dc.date.issued2014
dc.identifier.citationKiwanuka N, et al. (2014). High Incidence of HIV-1 infection in a general population of fishing communities around Lake Victoria, Uganda, PLoS ONE 9(5): 1-9en_US
dc.identifier.otherdoi:10.1371/journal.pone.0094932
dc.identifier.urihttp://hdl.handle.net/10570/4402
dc.description.abstractBackground: High HIV-1 incidence rates were reported among persons in fisherfolk communities (FFC) in Uganda who were selected for high risk behaviour. We assessed the incidence of HIV-1 and associated risk factors in a general population FFC to determine population-wide HIV rates. Methods: A community-based cohort study was conducted among a random sample of 2191 participants aged 18–49 years. At baseline and 12 months post-baseline, data were collected on socio-demographic characteristics and risky behaviors (including number of partners, new partners, condom use, use of alcohol and illicit drug use). Venous blood was collected for HIV serological testing. HIV incidence was calculated per 100 person years at-risk (pyar) and adjusted incidence rate ratios (Adj.IRR) were estimated by multivariable Poisson regression. Results: Overall follow up at 12 months was 76.9% (1685/2191) and was significantly higher among HIV uninfected persons and those with at least 1 year duration of stay in community. Overall HIV-1 incidence was 3.39/100 pyar (95% CI: 2.55–4.49). Among the 25–29 years who drank alcohol, HIV incidence was 7.67/100pyar (95% CI;4.62–12.7) while it was 5.67/100pyar (95% CI;3.14–10.2) for 18–24 year olds who drank alcohol. The risk of HIV infection was higher among 25–29 years (adj.IRR = 3.36; 95% CI: 1.48–7.65) and 18–24 years (adj.IRR = 2.65; 95% CI: 1.05–6.70) relative to 30+ years. Compared to nondrinkers, HIV incidence increased by frequency of alcohol drinking - occasional drinkers (adj.IRR = 3.18; 95% CI: 1.18–8.57) and regular drinkers (adj.IRR = 4.93; 95% CI: 1.91–12.8). Conclusion: HIV-1 incidence in general fisherfolk population along L.Victoria, Uganda, is high and is mainly associated with young age and alcohol drinking. HIV prevention and control strategies are urgently needed in this population.en_US
dc.description.sponsorshipUnited States Agency for International Development, Wellcome Trust, UK, and the Canada-Africa Prevention Trials Network (CAPTN)en_US
dc.language.isoenen_US
dc.publisherPLOS ONEen_US
dc.subjectHIV-1 Infectionen_US
dc.subjectFishing Communitiesen_US
dc.subjectLake Victoriaen_US
dc.subjectUgandaen_US
dc.titleHigh Incidence of HIV-1 Infection in a General Population of Fishing Communities around Lake Victoria, Ugandaen_US
dc.typeJournal articleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record