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Antimalarial drug levels in biological samples: methods and applications.
(2008-09)
This thesis deals with the development and validation of analytical methods that are field-adapted and their application in the determination of antimalarial drug levels in biological samples. These methods are suitable ...
Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults
(BioMed Central, 2012-04-27)
Background: Severe malaria is a medical emergency with high mortality. Prompt achievement of therapeutic concentrations of highly effective anti-malarial drugs reduces the risk of death. The aim of this study was to assess ...
Variations of plasma concentrations of artemether-lumefantrine with age and weight in children presenting with uncomplicated malaria at Mulago Hospital.
(2009-10)
INTRODUCTION:
Malaria is still one of the main causes of mortality and morbidity in Ugandan children with the under 5 year mortality rate of 136/100,000. ACTs are the first line of treatment of uncomplicated malaria. ...
Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study.
(University of Chicago Press, 2005-11-18)
Background. Human immunodeficiency virus (HIV) infection may increase the burden of malaria by increasing susceptibility to infection or by decreasing the response to antimalarial treatment. We investigated the seroprevalence ...
Treatment of severe sepsis with Artemether-Lumefantrine Is associated with decreased mortality in Ugandan patients without malaria
(The American Society of Tropical Medicine and Hygiene, 2009)
We enrolled 382 patients at two hospitals in Uganda in a prospective observational study of severe sepsis. Because artemisinins improve survival in murine sepsis models, we performed a post hoc analysis of the association ...
Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda
(Public Library of Science, 2008-06)
Background:
Uganda recently adopted artemether-lumefantrine (AL) as the recommended first-line treatment for uncomplicated malaria. However, AL has several limitations, including a twice-daily dosing regimen, recommendation ...
Intermittent use of sulphadoxine-pyrimethamine for malaria prevention: A cross-sectional study of knowledge and practices among Ugandan women attending an urban antenatal clinic.
(Malaria Journal, 2014)
Abstract
Background: The WHO recommends supervised administration of sulphadoxine-pyrimethamine (SP) as intermittent
preventive treatment for malaria (IPTp) during pregnancy. Logistical constraints have however favoured ...