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Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial
(BioMed Central, 2009-10-24)
Background: Malaria carries high case fatality among children with sickle cell anaemia. In Uganda, chloroquine is used for prophylaxis in these children despite unacceptably high levels of resistance. Intermittent presumptive ...
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.
(Oxford University Press, 2009-11-04)
Background. Amodiaquine (AQ) is paired with artesunate (AS) or sulfadoxine-pyrimethamine (SP) in recommended antimalarial regimens. It is unclear how readily AQ resistance will be selected with combination chemotherapy. ...
Assessment of the process of implementation of intermittent preventive treatment of malaria in pregnancy strategy in Tororo District, Uganda.
(2009)
INTRODUCTION:
Malaria in pregnancy is a long known problem in Uganda associated with maternal and child morbidity, mortality and disability. In Uganda, the MOH malaria control strategy mainly focuses on IPT, early diagnosis ...
Variations of plasma concentrations of artemether-lumefantrine with age and weight in children presenting with uncomplicated malaria at Mulago Hospital.
(2009-10)
INTRODUCTION:
Malaria is still one of the main causes of mortality and morbidity in Ugandan children with the under 5 year mortality rate of 136/100,000. ACTs are the first line of treatment of uncomplicated malaria. ...
Treatment of severe sepsis with Artemether-Lumefantrine Is associated with decreased mortality in Ugandan patients without malaria
(The American Society of Tropical Medicine and Hygiene, 2009)
We enrolled 382 patients at two hospitals in Uganda in a prospective observational study of severe sepsis. Because artemisinins improve survival in murine sepsis models, we performed a post hoc analysis of the association ...
Short report: assessing the impact of indoor residual spraying on malaria morbidity using a sentinel site surveillance system in Western Uganda
(American Society of Tropical Medicine and Hygiene, 2009)
A single round of indoor residual spraying (IRS) using lambda-cyhalothrin was implemented in a district of Uganda with moderate transmission intensity in 2007. Individual patient data were collected from one health facility ...
Sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine plus amodiaquine for treating uncomplicated malaria (Review)
(John Wiley, 2009)
Background Artemisinin-based combination treatments are strongly advocated, but supplies are limited. Sulfadoxine combined with amodiaquine is an alternative non-artemisinin combination. Objectives To compare sulfadoxine ...