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dc.contributor.authorNaamala, Allen
dc.contributor.authorEriksson, Lars E.
dc.contributor.authorOrem, Jackson
dc.contributor.authorNalwadda, Gorrette K.
dc.contributor.authorKabir, Zarina Nahar
dc.contributor.authorWettergren, Lena
dc.date.accessioned2023-03-23T11:33:40Z
dc.date.available2023-03-23T11:33:40Z
dc.date.issued2021-04-23
dc.identifier.citationNaamala, A., Eriksson, L. E., Orem, J., Nalwadda, G. K., Kabir, Z. N., & Wettergren, L. (2021). Psychometric properties of the EORTC QLQ-C30 in Uganda. Health and Quality of Life Outcomes, 19(1), 131.en_US
dc.identifier.issn1477-7525
dc.identifier.urihttps://doi.org/10.1186/s12955-021-01769-x
dc.identifier.urihttp://hdl.handle.net/10570/11918
dc.descriptionResearch Articleen_US
dc.description.abstractBackground: Self-reported measures play a crucial role in research, clinical practice and health assessment. Instruments used to assess self-reported health-related quality of life (HRQoL) need validation to ensure that they measure what they are intended to, detect true changes over time and differentiate between subjects. A generic instrument measuring HRQoL adapted for use among people living with cancer in Uganda is lacking; therefore, this study aimed to evaluate the psychometric properties of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 in patients with cancer in Uganda. Methods: Adult patients with various types of cancer (n = 385) cared for at the Uganda Cancer Institute answered the EORTC QLQ-C30 in Luganda or English language, the two most spoken languages in the country. The two language versions were evaluated with regard to data quality (floor and ceiling effects and missing responses), reliability (internal consistency) and validity (construct, known-group and criterion). Construct validity was examined through confirmatory factor analysis (CFA). Mean scores were compared between groups differing in disease stage to assess known-group validity. Criterion validity was examined according to associations between two QLQ-C30 subscales (Global quality of life and Physical function) and the Karnofsky Performance Scale (KPS). Results: Floor and ceiling effects were observed for several scales in the Luganda and English versions. All EORTC scales with the exception of Cognitive function (Luganda α = 0.66, English α = 0.50) had acceptable Cronbach’s alpha values (0.79–0.96). The CFA yielded good fit indices for both versions (RMSEA = 0.08, SRMR = 0.05 and CFI = 0.93). Known-group validity was demonstrated with statistically significant better HRQoL reported by patients with disease stages I–II compared to those in stages III–IV. Criterion validity was supported by positive correlations between KPS and the subscales Physical function (Luganda r = 0.75, English r = 0.76) and Global quality of life (Luganda r = 0.59, English r = 0.72). Conclusion: The Luganda and English versions of the EORTC QLQ-C30 appear to be valid and reliable measures and can be recommended for use in clinical research to assess HRQoL in adult Ugandans with cancer. However, the cognitive scale did not reach acceptable internal consistency and needs further evaluation. Keywords: Cancer, Cancer care, EORTC , Health-related quality of life, Quality of life, Sub-Saharan © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/. The Creative Commons Public Domain Dedication waiver (http:// creat iveco mmons. org/ publi cdoma in/ zero/1. 0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.en_US
dc.description.sponsorshipThe study was sponsored by the African Development Bank (AfDB) through the Uganda Cancer Institute (UCI)–AfDB scholarship Scheme.en_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.subjectCanceren_US
dc.subjectCancer careen_US
dc.subjectEORTCen_US
dc.subjectHealth-related quality of lifeen_US
dc.subjectQuality of lifeen_US
dc.subjectSub-Saharanen_US
dc.titlePsychometric properties of the EORTC QLQ‑C30 in Ugandaen_US
dc.typeArticleen_US


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