|The study screened for the Antibacterial activity of Capsicum Frutescens, Carica Papaya, Erythrina abyssinica, Eucalyptus globulus and Mangifera indica selected mediinal plants used to treat and prevent infections in Humans and Animals. The medicinal plants were collected from Botanical gardens and others from Wakiso District. The dry powders of the medicinal plants were extracted succesively with ether, ethanol and water (Aqueous). The resultant dry extracts were subjected to qualitative chemical tests, antibacterial activity tests and serial dilutions to obtain the minimum Inhibitory concentration(MIC) for those tested active. Mangifera Indica, Eucalyptus globulus and carica papaya were active against all the test Bacterial organisms (Styphylococcus aureus, Esherichia coli and Pseudomonas aeruginosa) while Erythrina abyssinica and capsicum frutescens didnot shw any activity.