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Inflammatory marker profiles and seizure control in children with Nodding syndrome on antiepileptic drug therapy
(Makerere University, 2018-09)
Background
Nodding syndrome (NS) is a neurological disorder afflicting patients in Africa. The disease progresses from a prodromal stage to head nodding (its distinctive feature). Thereafter, convulsive seizures, worsening ...
Second-line drug resistance markers as indicators of time to sputum culture conversion among selected mycobacterium tuberculosis clinical isolates at the Uganda National Tuberculosis Reference Laboratory
(2022)
Drug-resistant TB continues to be a global public health crisis, with low treatment success rates for Multi Drug Resistant/ Rifampicin Resistant TB and Extensively Drug-Resistant TB. Achieving sustained bacteriological ...
Sero prevalence and Brucella species circulating among small ruminants and their attendants in Kasese and Rubirizi Districts, South-Western Uganda
(Makerere University, 2022-09-05)
In Uganda, brucellosis is more widely studied in cattle than in other species of animals. A few studies conducted on Brucellosis in small ruminants suggest that there exists a significant association between caprine, ovine ...
Insilico identification, characterisation of plasmodium falciparum hypothetical proteins and their assessment as molecular targets for malaria vaccine
(Makerere University, 2023-06)
This thesis focused on malaria vaccinology and employed reverse vaccinology and molecular techniques to predict potential vaccine candidates against P. falciparum malaria. Reverse vaccinology is fundamentally an in silico ...
Effectiveness of RNA interference against black Sigatoka in transgenic dessert banana
(Makerere University, 2019)
Black Sigatoka (BS) caused by Mycosphaerella fijiensis [M. fijiensis] is a worldwide foliar disease constraint of banana and plantain, leading to 30-50% yield losses. Control of BS through spraying with mineral oil-based ...
Molecular characterization of transmitted/founder HIV-1 envelope Glycoproteins of Subtypes D and AD Recombinant viruses
(Makerere University, 2021-02)
Infection by HIV-1 among heterosexuals most often results from successful transmission and propagation of a single virus variant, called Transmitted/Founder virus (TFV). This indicates that TFV have particular traits over ...
Free-roaming domestic dog ecology: Population size and management in Soroti City
(Makerere University, 2022-08)
Free-roaming dogs pose a public health threat. They are involved in the transmission of diseases to humans, livestock and wildlife. These dogs interact with many people, other dogs, and animals and are the most commonly ...
Temporal dynamics of enterobacteriaceae antimicrobial resistance at the human-pig interface in peri-urban Kampala
(Makerere University, 2019-07)
Antimicrobial resistance (AMR) leads to increased mortality, morbidity and health expenditure. Globally, there is an increasing concern over AMR which is claiming 700,000 people every year and this is projected to 10,000,000 ...
Antiretroviral resistance mutation profiles among drug regimens and HIV-1 Subtypes in Uganda
(Makerere University, 2019-05)
Antiretroviral drug resistance is highly considered as a key limiting factor in HIV management because of its varying impact across drug regimens and HIV-1 subtypes. In Uganda, there is a paucity of data on how this factor ...
Hot water therapy and meristem shoottip culture techniques for elimination of cassava viral pathogens
(2018-10)
Cassava Mosaic Disease (CMD) and Cassava Brown Streak Disease (CBSD) are two main viruses affecting Cassava productivity in many agro ecologies of Uganda. Phytosanitary procedures to eliminate these viruses from infected ...