Browsing by Author "Dorsey, Grant"
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The age-specific incidence of hospitalized paediatric malaria in Uganda
Mpimbaza, Arthur; Walemwa, Richard; Kapisi, James; Sserwanga, Asadu; Namuganga, Jane Frances; Kisambira, Yasin; Tagoola, Abner; Nanteza, Jane Frances; Rutazaana, Damain; Staedke, Sarah G.; Dorsey, Grant; Opigo, Jimmy; Kamau, Alice; Snow, Robert W. (BMC, 2020)Background: Understanding the relationship between malaria infection risk and disease outcomes represents a fundamental component of morbidity and mortality burden estimations. Contemporary data on severe malaria risks ... -
Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda
Yeka, Adoke; Kamya, Moses R.; Dorsey, Grant; Talisuna, Ambrose; Lugemwa, Myers; Rwakimari, John Bosco; Staedke, Sarah G.; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Bukirwa, Hasifa (Public Library of Science, 2008-06)Background: Uganda recently adopted artemether-lumefantrine (AL) as the recommended first-line treatment for uncomplicated malaria. However, AL has several limitations, including a twice-daily dosing regimen, recommendation ... -
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial.
Kamya, Moses.R; Yeka, Adoke; Bukirwa, Hasifa; Lugemwa, Myers; Rwakimari, John B.; Staedke, Sarah G.; Talisuna, Ambrose O.; Greenhouse, Bryan; Nosten, Francois; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Dorsey, Grant (2007-05-18)Objectives: To compare the efficacy and safety of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for treating uncomplicated falciparum malaria in Uganda. Design: Randomized single-blinded clinical ... -
Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda
Bukirwa, Hasifa; Talisuna, Ambrose; Yeka, Adoke; Kamya, Moses R; Talisuna, Ambrose O.; Banek, Kristin; Bakyaita, Nathan; Rwakimari, John Bosco; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Dorsey, Grant; Staedke, Sarah G. (Public Library of Science, 2006-05)Objectives: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. Design: Randomized single-blind controlled trial. Setting: Tororo, Uganda, ... -
Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda
Banek, Kristin; Yeka, Adoke; Bakyaita, Nathan; Staedke, Sarah G.; Talisuna, Ambrose; Kironde, Fred; Kamya, Moses.R; Nsobya, Samuel L.; Kilian, Albert; Slater, Madeline; Dorsey, Grant; Wabwire-Mangen, Fred; Rosenthal, Philip J.; Reingold, Arthur (Public Library of Science, 2005-07)Background Drug resistance in Plasmodium falciparum poses a major threat to malaria control. Combination antimalarial therapy including artemisinins has been advocated recently to improve efficacy and limit the spread of ... -
Association between indoor residual spraying and pregnancy outcomes: a quasi-experimental study from Uganda
Roh, Michelle E.; Mpimbaza, Arthur; Oundo, Brenda; Irish, Amanda; Murphy, Maxwell; Wu, Sean L.; White, Justin S.; Shiboski, Stephen; Glymour, M. Maria; Gosling, Roly; Dorsey, Grant; Sturrock, Hugh (Oxford University Press, 2022)Background: Malaria is a risk factor for adverse pregnancy outcomes. Indoor residual spraying with insecticide (IRS) reduces malaria infections, yet the effects of IRS on pregnancy outcomes are not well established. We ... -
Complexity of plasmodium falciparum clinical samples from Uganda during short-term culture.
Nsobya, Samuel L.; Kiggundu, Moses; Joloba, Moses; Dorsey, Grant; Rosentha, Philip J. (University of Chicago Press, 2008-08-22)We cultured Plasmodium falciparum parasites from 98 Ugandan children with malaria and determined the complexity of infection (COI) on the basis of msp-2 polymorphisms daily for 9 days. The mean COI decreased during culture ... -
Complexity of plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda.
Sulggi, Less A.; Nsobya, Samuel L.; Yeka, Adoke; Dokomajilar, Christian; Rosenthal, Philip J.; Talisuna, Ambrose; Dorsey, Grant (University of Chicago Press, 2006-03-13)Malaria infections in Africa frequently include multiple parasite strains.We examined the relationship between the number of infecting Plasmodium falciparum strains and the responses to 3 different combination therapies ... -
Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study.
Kamya, Moses R.; Gasasira, Anne F.; Yeka, Adoke; Bakyaita, Nathan; Nsobya, Samuel L.; Damon, Francis; Rosenthal, Philip J.; Dorsey, Grant; Havlir, Diane (University of Chicago Press, 2005-11-18)Background. Human immunodeficiency virus (HIV) infection may increase the burden of malaria by increasing susceptibility to infection or by decreasing the response to antimalarial treatment. We investigated the seroprevalence ... -
Malaria diagnosed in an urban setting strongly associated with recent overnight travel: A case–control study from Kampala, Uganda
Arinaitwe, Emmanuel; Mpimbaza, Arthur; Nankabirwa, Joaniter I.; Kamya, Victor; Asiimwe, Alan; Kuule, Julius K.; Kamya, Moses R.; Drakeley, Chris; Dorsey, Grant; Rosenthal, Philip J.; Staedke, Sarah G. (2020)Malaria is frequently diagnosed in urban Kampala, despite low transmission intensity. To evaluate the association between recent travel out of Kampala and malaria, we conducted a matched case–control study. Cases were ... -
Practical implications of a relationship between health management information system and community cohort–based malaria incidence rates
Kigozi, Simon P.; Giorgi, Emanuele; Mpimbaza, Arthur; Kigozi, Ruth N.; Bousema, Teun; Arinaitwe, Emmanuel; Nankabirwa, Joaniter I.; Sebuguzi, Catherine M.; Kamya, Moses R.; Staedke, Sarah G.; Dorsey, Grant; Pullan, Rachel L. (2020)Global malaria burden is reducing with effective control interventions, and surveillance is vital to maintain progress. Health management information system (HMIS) data provide a powerful surveillance tool; however, its ... -
A quasi-experimental study estimating the impact of long-lasting insecticidal nets with and without piperonyl butoxide on pregnancy outcomes
Roh, Michelle E.; Oundo, Brenda; Dorsey, Grant; Shiboski, Stephen; Gosling, Roly; Glymour, M. Maria; Staedke, Sarah G.; Bennett, Adam; Sturrock, Hugh; Mpimbaza, Arthur (BMC, 2022)Background: Long-lasting insecticidal nets (LLINs) are the main vector control tool for pregnant women, but their efficacy may be compromised, in part, due to pyrethroid resistance. In 2017, the Ugandan Ministry of Health ... -
Rapid shifts in the age‑specific burden of malaria following successful control interventions in four regions of Uganda
Kigozi, Simon P.; Kigozi, Ruth N.; Epstein, Adrienne; Mpimbaza, Arthur; Sserwanga, Asadu; Yeka, Adoke; Nankabirwa, Joaniter I.; Halliday, Katherine; Pullan, Rachel L.; Rutazaana, Damian; Sebuguzi, Catherine M.; Opigo, Jimmy; Kamya, Moses R.; Staedke, Sarah G.; Dorsey, Grant; Greenhouse, Bryan; Rodriguez‑Barraquer, Isabel (BMC, 2020)Background: Malaria control using long-lasting insecticidal nets (LLINs) and indoor residual spraying of insecticide (IRS) has been associated with reduced transmission throughout Africa. However, the impact of transmission ... -
Selection of plasmodium falciparum pfmdr1 Alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic
Nsobya, Samuel L.; Dokomajilar, Christian; Greenhouse, Bryan; Rosenthal, Philip J.; Dorsey, Grant (American Society for Microbiology, 2006-03-08)Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N,184F, and 1246D ... -
Short report: assessing the impact of indoor residual spraying on malaria morbidity using a sentinel site surveillance system in Western Uganda
Bukirwa, Hasifa; Yau, Vincent; Kigozi, Ruth; Filler, Scott; Quick, Linda; Lugemwa, Myers; Dissanayake, Gunawardena; Kamya, Moses; Wabwire-Mangen, Fred; Dorsey, Grant (American Society of Tropical Medicine and Hygiene, 2009)A single round of indoor residual spraying (IRS) using lambda-cyhalothrin was implemented in a district of Uganda with moderate transmission intensity in 2007. Individual patient data were collected from one health facility ... -
Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda
Bakyaita, Nathan; Dorsey, Grant; Adoke, Yeka; Banek, Kristin; Staedke, Sarah G.; Kamya, Moses R.; Talisuna, Ambrose; Kironde, Fred; Nsobya, Sam; Kilian, Albert; Reingold, Arthur; Rosenthal, Philip J.; Wabwire-Mangen, Fred (2005)The use of combinations of inexpensive drugs for the treatment of malaria in Africa has been proposed as an interim policy while awaiting the widespread availability of more effective regimens. We compared sulfadoxinepyrimethamine ... -
Urban malaria: primary caregivers’ knowledge, attitudes, practices and predictors of malaria incidence in a cohort of Ugandan children
Njama, Denise; Dorsey, Grant; Guwatudde, David; Kigonya, Kate; Greenhouse, Bryan; Musisi, Stephen; Kamya, Moses R. (Wiley-Blackwell, 2003-08)Objectives: To assess malaria-related knowledge, attitude and practices (KAP) among primary caregivers, to identify associations between primary caregivers' characteristics and positive KAP towards malaria, and to identify ... -
Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children
Jensen, Trevor P.; Bukirwa, Hasifa; Njama-Meya, Denise; Damon, Francis; Kamya, Moses R; Rosenthal, Philip J; Dorsey, Grant (BioMed Central, 2009-09-15)Background: As malaria control efforts intensify, it is critical to monitor trends in disease burden and measure the impact of interventions. A key surveillance indicator is the incidence of malaria. Yet measurement of ...