Browsing by Subject "Mycobacterium tuberculosis"
Now showing items 21-32 of 32
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Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV prevalence setting: a prospective cohort study
(Public Library of Science, 2011-01)Background: Nucleic acid amplification tests are sensitive for identifying Mycobacterium tuberculosis in populations with positive sputum smears for acid-fast bacilli, but less sensitive in sputum-smear-negative populations. ... -
Patient single nucleotide polymorphisms assiocated with Mycobacterium tuberculosis genotypes in Ugandan population
(Makerere University, 2022-12)Uganda is one of the 30 World Health Organization-designated countries with a high burden of TB/HIV, with three main dominant genotypes that cause tuberculosis. Recent studies have shown that the M. tuberculosis Uganda ... -
Performance evaluation of the Uganda National Algorithm for Diagnosis of tuberculosis in children at Mulago National Referral Hospital-Kampala, Uganda
(Makerere University, 2023)Background Diagnosing childhood tuberculosis (TB) is a challenge, this led the Uganda national tuberculosis control program (NTLP) to develop a clinical treatment decision algorithm for children. However, there is limited ... -
Practices of diagnosis and treatment of pulmonary tuberculosis, associated factors, barriers and facilitators among private practitioners in Kampala, Uganda
(Makerere University, 2020-11)Introduction: Globally, tuberculosis (TB) is a leading cause of morbidity and mortality accounting for an estimated 10.0 million new cases and 1.451million deaths in 2018. Uganda is one of the world’s high TB burden countries ... -
Reverse vaccinology and molecular docking as tools to identify potential vaccine candidates against drug-resistant Mycobacterium tuberculosis and Mycobacterium bovis
(Makerere University, 2022-03-29)The emergence of multi-drug-resistant Mycobacterium tuberculosis (M.tb) and Mycobacterium bovis (M.bovis), the causative agents of Tuberculosis (TB) and zoonotic TB respectively are of significant threat to public health. ... -
Second-line drug resistance markers as indicators of time to sputum culture conversion among selected mycobacterium tuberculosis clinical isolates at the Uganda National Tuberculosis Reference Laboratory
(2022)Drug-resistant TB continues to be a global public health crisis, with low treatment success rates for Multi Drug Resistant/ Rifampicin Resistant TB and Extensively Drug-Resistant TB. Achieving sustained bacteriological ... -
The sensitivity and specificity of pleural fluid MTB-specific elispot assay among adults with suspected tuberculous pleurisy compared to pleural biopsy in Mulago Hospital
(Makerere University, 2009)Introduction and rationale: Pleural effusions are a common reason for admission in Mulago hospital and tuberculosis is the most common infectious cause. The diagnosis of tuberculous pleural effusion with standard analysis ... -
Strain diversity of mycobacterium tuberculosis non-Uganda isolates from patients with pulmonary tuberculosis in Kawempe
(Makerere University, 2013-05)Background: Tuberculosis is a major public health problem in peri-urban areas of Kampala and Uganda in general. To date there is inconclusive information about strain diversity of Mycobacterium tuberculosis of the non ... -
Time to tuberculosis treatment default and its determinants among adult TB patients in Jinja District, A retrospective cohort study
(Makerere University, 2015-10)Introduction: Whereas Tuberculosis is both preventable and curable, the disease remains a global health problem causing ill-health among millions of people each year and ranks as the second leading cause of death from an ... -
Tuberculosis immune reconstitution inflammatory syndrome in countries with limited resources
(International Union Against Tuberculosis and Lung Disease, 2006)Mycobacterium tuberculosis infection accounts for probably one third of human immunodeficiency virus (HIV)related immune reconstitution inflammatory syndrome (IRIS) events, particularly in developing countries where HIV ... -
Tuberculosis immune reconstitution inflammatory syndrome in countries with limited resources
(International Union Against Tuberculosis and Lung Disease, 2006)Mycobacterium tuberculosis infection accounts for probably one third of human immunodeficiency virus (HIV)related immune reconstitution inflammatory syndrome (IRIS) events, particularly in developing countries where HIV ... -
The use of Genotype MTBDRplus assay to assess drug resistance of microbacterium tuberculosis isolates from patients in rural Uganda
(BioMed Central, 2010)Background: Drug resistance levels and patterns among Mycobacterium tuberculosis isolates from newly diagnosed and previously treated tuberculosis patients in Mbarara Uganda were investigated. Methods: We enrolled, ...